Title:
DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS
Document Type and Number:
WIPO Patent Application WO/2018/141002
Kind Code:
A3
Abstract:
A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of one or more CDK enzyme and/or by one or more aberrant CDK activity, including certain cancers of lung, breast, brain, ovary, prostate, colorectal cancer and leukaemias. The inhibitors have the general structure (I).
Inventors:
WANG SHUDONG (AU)
AL HAJ DIAB SARAH (AU)
LONG YI (AU)
AL HAJ DIAB SARAH (AU)
LONG YI (AU)
Application Number:
PCT/AU2018/000011
Publication Date:
November 22, 2018
Filing Date:
February 01, 2018
Export Citation:
Assignee:
UNIV SOUTH AUSTRALIA (AU)
International Classes:
C07D471/04; A61K31/437; A61K31/506; A61P35/00
Domestic Patent References:
| WO2015154039A2 | 2015-10-08 | |||
| WO2003000682A1 | 2003-01-03 | |||
| WO2006038001A1 | 2006-04-13 | |||
| WO2003000689A1 | 2003-01-03 | |||
| WO2003031446A1 | 2003-04-17 |
Foreign References:
| US8569306B2 | 2013-10-29 |
Other References:
ALAM, M. ET AL.: "Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 12, 15 June 2007 (2007-06-15), pages 3463 - 3467, XP022097804
PALMER, W. S. ET AL.: "Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-ben zotriazole lead", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 5, 22 December 2012 (2012-12-22), pages 1486 - 1492, XP028976507
BUCKLEY, G. M. ET AL.: "IRAK -4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 11, 22 April 2008 (2008-04-22), pages 3291 - 3295, XP055549407
PALMER, W. S. ET AL.: "Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-ben zotriazole lead", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 5, 22 December 2012 (2012-12-22), pages 1486 - 1492, XP028976507
BUCKLEY, G. M. ET AL.: "IRAK -4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 11, 22 April 2008 (2008-04-22), pages 3291 - 3295, XP055549407
Attorney, Agent or Firm:
MADDERNS PATENT & TRADE MARK ATTORNEYS (AU)
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