Title:
DERIVATIVES OF PHENYLMETHANONE AS FTO INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2019/129121
Kind Code:
A1
Abstract:
Disclosed herein is a phenyl methanone derivative as an FTO inhibitor. Also disclosed herein is a pharmaceutical composition comprising the same, and a method for reducing food intake or appetite, inhibiting weight gain, promote weight loss, reducing blood glucose, reducing serum LDL, cholesterol, LDL-c, or triglycerides, or treating obesity or an obesity related disease (especially diabetes, hyperglycemia, diabetic nephropathy, hyperlipemia, coronary heart disease, atherosclerosis, hypertension, cardiovascular or cerebrovascular disease, liver, kidney or thyroid diseases) by inhibiting FTO by using the compound disclosed herein.
Inventors:
LI WEI (CN)
ZHANG WEI (CN)
HUANG NIU (CN)
ZHANG WEI (CN)
HUANG NIU (CN)
Application Number:
PCT/CN2018/124186
Publication Date:
July 04, 2019
Filing Date:
December 27, 2018
Export Citation:
Assignee:
RPXDS CO LTD (CN)
International Classes:
C07C37/00; A61K31/00; A61P3/04
Domestic Patent References:
| WO2000037423A1 | 2000-06-29 | |||
| WO2001098251A1 | 2001-12-27 |
Foreign References:
| US5236952A | 1993-08-17 | |||
| KR20110137166A | 2011-12-22 | |||
| US20130316985A1 | 2013-11-28 |
Other References:
LEARMONTH, DAVID A. ET AL.: "Improved method for demethylation of nitro-catechol methyl ethers", SYNTHETIC COMMUNICATIONS, vol. 32, no. 4, 31 December 2002 (2002-12-31), pages 641 - 649, XP001083026, doi:10.1081/SCC-120002413
DAVID A. LEARMONTHET ET AL.: "sthesis of 1-(3, 4-Dihydroxy-5-nitrophenyl)-2-phenyl- ethanone and Derivatives as Potent and Long-Acting Peripheral Inhibitors of Catechol-O- methyltransferase", J. MED. CHEM., vol. 45, 31 December 2002 (2002-12-31), pages 685 - 695, XP008139333, doi:10.1021/jm0109964
DATABASE REGISTRY 2 February 2009 (2009-02-02), Database accession no. 1099314-19-8
DATABASE REGISTRY 1 February 2009 (2009-02-01), Database accession no. 1098587-69-9
DATABASE REGISTRY 19 November 2004 (2004-11-19), Database accession no. 784131-58-4
DATABASE REGISTRY 11 October 2004 (2004-10-11), Database accession no. 760165-65-9
DATABASE REGISTRY Database accession no. 749200-31-5
DATABASE REGISTRY 9 July 2004 (2004-07-09), Database accession no. 706756-60-7
DAVID A. LEARMONTHET ET AL.: "sthesis of 1-(3, 4-Dihydroxy-5-nitrophenyl)-2-phenyl- ethanone and Derivatives as Potent and Long-Acting Peripheral Inhibitors of Catechol-O- methyltransferase", J. MED. CHEM., vol. 45, 31 December 2002 (2002-12-31), pages 685 - 695, XP008139333, doi:10.1021/jm0109964
DATABASE REGISTRY 2 February 2009 (2009-02-02), Database accession no. 1099314-19-8
DATABASE REGISTRY 1 February 2009 (2009-02-01), Database accession no. 1098587-69-9
DATABASE REGISTRY 19 November 2004 (2004-11-19), Database accession no. 784131-58-4
DATABASE REGISTRY 11 October 2004 (2004-10-11), Database accession no. 760165-65-9
DATABASE REGISTRY Database accession no. 749200-31-5
DATABASE REGISTRY 9 July 2004 (2004-07-09), Database accession no. 706756-60-7
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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