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Patent Searching and Data


Title:
DERIVATIVES OF THAILANSTATIN A, METHODS OF TREATMENT AND METHODS OF SYNTHESIS THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/214423
Kind Code:
A3
Abstract:
In one aspect, the present disclosure provides analogs of thailanstatin of the formula wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.

Inventors:
NICOLAOU KYRIACOS C (US)
RHOADES DERK (US)
KUMAR SOUNDARAPANDIAN M (US)
PATTANAYAK MANAS R (US)
LAMANI MANJUNATH (US)
Application Number:
PCT/US2017/036589
Publication Date:
January 11, 2018
Filing Date:
June 08, 2017
Export Citation:
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Assignee:
UNIV RICE WILLIAM M (US)
International Classes:
C07D491/052; C07D498/18; C12P17/18
Domestic Patent References:
WO2009031999A12009-03-12
WO2015077370A12015-05-28
Foreign References:
US20140134193A12014-05-15
US20080096879A12008-04-24
US20140221207A12014-08-07
Other References:
LIU ET AL.: "Genomics -Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailand ensis MSMB43", JOURNAL OF NATURAL PRODUCTS, vol. 76, 21 May 2013 (2013-05-21), pages 685 - 693, XP055451555
HE ET AL.: "Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues", JOURNAL OF NATURAL PRODUCTS, vol. 77, 6 August 2014 (2014-08-06), pages 1864 - 1870, XP055451569
Attorney, Agent or Firm:
LONG, Reid, S. (US)
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