Title:
DERMASEPTIN-TYPE AND PISCIDIN-TYPE ANTIMICROBIAL PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2015/112980
Kind Code:
A3
Abstract:
Antimicrobial agents, including antimicrobial peptides (AMPs) and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptides that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPS change selectivity from broad spectrum antimicrobial activity to AMPS with gram-negative selectivity.
More Like This:
Inventors:
JIANG ZIQING (US)
HODGES ROBERT S (US)
GERA LAJOS (US)
MANT COLIN T (US)
HODGES ROBERT S (US)
GERA LAJOS (US)
MANT COLIN T (US)
Application Number:
PCT/US2015/012913
Publication Date:
October 29, 2015
Filing Date:
January 26, 2015
Export Citation:
Assignee:
UNIV COLORADO REGENTS (US)
International Classes:
A01N37/18; A61K38/00; A61K38/04; A61K38/40; A61K47/48; C07K5/00; C07K14/79
Foreign References:
| KR20100065639A | 2010-06-17 |
Other References:
LEE ET AL.: "Solution structure and cell selectivity of piscidin 1 and its analogues.", BIOCHEMISTRY, vol. 46, no. 12, 2007, pages 3653 - 63, XP002555736, ISSN: 0006-2960
CHEKMENEV ET AL.: "Investigating molecular recognition and biological function at interfaces using piscidins, antimicrobial peptides from fish.", BIOCHIM BIOPHYS ACTA, vol. 1758, no. 9, 2006, pages 1359 - 72, XP027916004, ISSN: 0005-2736
FEDER ET AL.: "Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity.", J BIOL CHEM., vol. 275, no. 6, 2000, pages 4230 - 4238, XP002405647, ISSN: 0021-9258
See also references of EP 3096616A4
CHEKMENEV ET AL.: "Investigating molecular recognition and biological function at interfaces using piscidins, antimicrobial peptides from fish.", BIOCHIM BIOPHYS ACTA, vol. 1758, no. 9, 2006, pages 1359 - 72, XP027916004, ISSN: 0005-2736
FEDER ET AL.: "Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity.", J BIOL CHEM., vol. 275, no. 6, 2000, pages 4230 - 4238, XP002405647, ISSN: 0021-9258
See also references of EP 3096616A4
Attorney, Agent or Firm:
TRAVER, Robert, D. (1560 BroadwaySuite 120, Denver CO, US)
Download PDF: