DESIGN OF CURCUMIN-PEPTIDE COMPLEX HAVING IMPROVED SOLUBILITY AND FUNCTION COMPARED WITH CURCUMIN AND METHOD FOR PREPARING CURCUMIN-PEPTIDE COMPLEX

WIPO Patent Application WO/2014/175556

A1

The present invention relates to a curcumin-peptide complex having improved solubility in water compared with curcumin; to a method for improving solubility of curcumin in water; to a method for preparing the complex; and to a cosmetic composition and a functional health food which contain the complex. The present invention provides a curcumin-peptide complex in which a peptide material validated to have biocompatibility and safety is linked to curcumin as a natural resource having a very excellent functional effect via a linker compound, and the curcumin-peptide complex is completely dissolved in water. The present invention provides a method for improving solubility of curcumin in water, thereby contributing to an increase in availability of curcumin as medicines, cosmetics, and food.

KANG SUNG JIN (KR)
KIM SAN HO (KR)
PARK JIN SOON (KR)
BAN SOO HO (KR)
PARK JIN SUK (KR)

PCT/KR2014/002446

October 30, 2014

March 24, 2014

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ANYGEN CO LTD (KR)

A61K47/48; A61K31/12; A61K47/42

US20110263500A1	2011-10-27
US20100316631A1	2010-12-16
US20120288533A1	2012-11-15
CN102250204A	2011-11-23

DUBEY, SHIV K. ET AL.: "Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, pages 1837 - 1846, XP025404783, DOI: doi:10.1016/j.ejmech.2007.11.027

YANG, Boo-Hyun (Chungdong Building 1922, Nambusunhwan-ro,Gwanak-gu, Seoul 151-832, KR)

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