DESIGN AND SYNTHESIS OF RENAL DIPEPTIDASE INHIBITORS

Title:

DESIGN AND SYNTHESIS OF RENAL DIPEPTIDASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2004010846

Kind Code:

A3

Abstract:

Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.

Inventors:

KHAN SAEED R (US)
VOGELSTEIN BERT (US)
KINZLER KENNETH W (US)
GURULINGAPPA HALLUR (US)
BUCKHAULTS PHILLIP (US)

Application Number:

PCT/US2003/023363

Publication Date:

August 12, 2004

Filing Date:

July 28, 2003

Export Citation:

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Assignee:

HOPKINS J SCHOOL OF MEDICINE (US)
KHAN SAEED R (US)
VOGELSTEIN BERT (US)
KINZLER KENNETH W (US)
GURULINGAPPA HALLUR (US)
BUCKHAULTS PHILLIP (US)

International Classes:

C07B59/00; C07F9/30; (IPC1-7): C07F9/32; A61K31/662

Other References:

DATABASE CAPLUS ON STN GURULINGAPPA, HALLUR ET AL: "DESIGN, SYNTHESIS AND EVALUATION OF NEW RDP INHIBITORS", XP002977227, Database accession no. 2003:114414

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