Title:
DETECTING APOPTOTTC BODIES BY IMPEDANCE CYTOMETRY AS AN INDICATOR OF DRUG SENSITIVITY
Document Type and Number:
WIPO Patent Application WO/2023/244893
Kind Code:
A3
Abstract:
A microfluidic system can be used to quantify apoptotic bodies (ABs) with single-cell sensitivity, providing real-time information regarding the presence, and properties of ABs. Different subpopulations of ABs can thus be distinguished from one another to quantify cellular dis-assembly and drug sensitivity of the cancer cells under test. Impedance measurement can be performed by flowing secreted bodies at a substantially single-particle sensitivity. A plurality of electrical impedance magnitude and phase parameters of the biological sample can be measured within the flow cell structure, corresponding to a specified range of frequencies to help determine a biological characteristic of the cancer cells.
Inventors:
SWAMI NATHAN (US)
BAUER TODD (US)
SALAHI ARMITA (US)
HONRADO CARLOS MANUEL FERNANDES (PT)
BAUER TODD (US)
SALAHI ARMITA (US)
HONRADO CARLOS MANUEL FERNANDES (PT)
Application Number:
PCT/US2023/067113
Publication Date:
April 18, 2024
Filing Date:
May 17, 2023
Export Citation:
Assignee:
UNIV VIRGINIA PATENT FOUNDATION (US)
SWAMI NATHAN (US)
BAUER TODD (US)
SALAHI ARMITA (US)
HONRADO CARLOS MANUEL FERNANDES (PT)
SWAMI NATHAN (US)
BAUER TODD (US)
SALAHI ARMITA (US)
HONRADO CARLOS MANUEL FERNANDES (PT)
International Classes:
G01N15/10; G01N33/48; G01N33/50
Attorney, Agent or Firm:
PERDOK, Monique M. et al. (US)
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