Title:
DETECTION OF ALZHEIMER'S DISEASE (AD), FRONTOTEMPORAL LOBAR DEGENERATION (FTLD), AMYOTROPHIC LATERAL SCHLEROSIS (ALS), PARKINSON'S DISEASE (PD), AND DEMENTIA WITH LEWY BODIES (DLB) INDICATED BY PHOSPHORYLATION OF MARCKS
Document Type and Number:
WIPO Patent Application WO/2019/172427
Kind Code:
A1
Abstract:
Provided is a method for detecting, with high sensitivity and high specificity, neurodegenerative diseases selected from the group consisting of human Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and amyotrophic lateral schlerosis (ALS). A method for detecting neurodegenerative diseases selected from the group consisting of human Alzeimer's disease (AD), frontotemporal lobar degeneration (FTLD), and amyotrophic lateral schlerosis (ALS), the method including the following steps: (i) a step for measuring MARCKS protein phosphorylated on serine 46 in a test specimen collected from a subject, and also measuring non-phosphorylated MARCKS protein; (ii) a step for calculating the DO value represented by Formula 1 from measurement values obtained in step (i) (in the formula, "pSer46-MARCKS" indicates the quantity of MARCKS protein phosphorylated on serine 46, and "non-phosphorylated-MARCKS" indicates the quantity of non-phosphorylated MARCKS protein); and (iii) a step for detecting a neurodegenerative disease using the DO value as an index.
Inventors:
OKAZAWA HITOSHI (JP)
Application Number:
PCT/JP2019/009370
Publication Date:
September 12, 2019
Filing Date:
March 08, 2019
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
DENKA SEIKEN KK (JP)
DENKA SEIKEN KK (JP)
International Classes:
G01N33/68; G01N27/62
Domestic Patent References:
| WO2015099094A1 | 2015-07-02 |
Foreign References:
| US20130196925A1 | 2013-08-01 | |||
| JP2018043641A | 2018-03-22 | |||
| JP2018138785A | 2018-09-06 |
Other References:
FUJITA, K. ET AL.: "HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer' s disease", SCIENTIFIC REPORTS, vol. 6, no. 31895, 25 August 2016 (2016-08-25), pages 1 - 15, XP055463477
TAGAWA, K. ET AL.: "Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer' s disease brain", HUMAN MOLECULAR GENETICS, vol. 24, no. 2, 17 September 2014 (2014-09-17), pages 540 - 558, XP055640705
KIMURA, T. ET AL.: "Phosphorylation of MARCKS in Alzheimer disease brains", NEUROREPORT, vol. 11, no. 4, 20 March 2000 (2000-03-20), pages 869 - 873, XP008184615, doi:10.1097/00001756-200003200-00042
TAGAWA, K. ET AL., HUM. MOL. GENET., vol. 24, 2015, pages 540 - 58
FUJITA, K. ET AL., SCI. REP., vol. 6, 2016, pages 31895
TAGAWA ET AL., HUM MOL GENET, vol. 24, 2015, pages 540 - 558
FUJITA ET AL., SCI REP, vol. 6, 2016, pages 31895
YAMAKADO ET AL., NEUROSCI RES, vol. 73, 2012, pages 173 - 177
SHILOV ET AL., MOL421 CELL PROTEOMICS, vol. 6, 2007, pages 1638 - 1655
TAGAWA, K. ET AL.: "Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer' s disease brain", HUMAN MOLECULAR GENETICS, vol. 24, no. 2, 17 September 2014 (2014-09-17), pages 540 - 558, XP055640705
KIMURA, T. ET AL.: "Phosphorylation of MARCKS in Alzheimer disease brains", NEUROREPORT, vol. 11, no. 4, 20 March 2000 (2000-03-20), pages 869 - 873, XP008184615, doi:10.1097/00001756-200003200-00042
TAGAWA, K. ET AL., HUM. MOL. GENET., vol. 24, 2015, pages 540 - 58
FUJITA, K. ET AL., SCI. REP., vol. 6, 2016, pages 31895
TAGAWA ET AL., HUM MOL GENET, vol. 24, 2015, pages 540 - 558
FUJITA ET AL., SCI REP, vol. 6, 2016, pages 31895
YAMAKADO ET AL., NEUROSCI RES, vol. 73, 2012, pages 173 - 177
SHILOV ET AL., MOL421 CELL PROTEOMICS, vol. 6, 2007, pages 1638 - 1655
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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