Title:
DETECTION OF ALZHEIMER'S DISEASE AND OTHER DISEASES USING A PHOTOAFFINITY LABELING METHOD
Document Type and Number:
WIPO Patent Application WO1993012755
Kind Code:
A3
Abstract:
The present invention relates to a novel method for the diagnosis of Alzheimer's disease using cerebrospinal fluid. More particularly, this method consists in contacting a sample of cerebrospinal fluid which contains a glutamine synthetase, having an apparent MT of about 42 000 daltons, with a labeled antibody specific for said glutamine synthetase under conditions that allow the formation of glutamine synthetase-antibody complex formation ; detecting the presence of said glutamine synthetase-antibody complexes ; and correlating the presence of said complexes with the presence of Alzheimer's disease.
Inventors:
HALEY BOYD E (US)
Application Number:
PCT/US1992/010908
Publication Date:
August 05, 1993
Filing Date:
December 23, 1992
Export Citation:
Assignee:
UNIV KENTUCKY RES FOUND (US)
International Classes:
A61K39/395; G01N33/50; G01N33/53; G01N33/573; G01N33/574; G01N33/60; G01N33/68; (IPC1-7): A61K/
Domestic Patent References:
| WO1991009311A1 | 1991-06-27 | |||
| WO1990015331A1 | 1990-12-13 |
Other References:
EUROPEAN NEUROLOGY vol. 22, February 1983, BASEL, CH pages 65 - 69 UNGER W. ET AL.
ANNALS OF NEUROLOGY vol. 26, no. 2, August 1989, BOSTON,MA,USA pages 210 - 215 S. KHATOON ET AL. cited in the application
NEUROSCIENCE LETTERS vol. 130, 1991, IRELAND pages 89 - 91 S.SYRJ[NEN ET AL.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 88, December 1991, WASHINGTON US pages 10540 - 10543 C.D.SMITH ET AL.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 89, December 1992, WASHINGTON US pages 11949 - 11953 D.GUNNERSEN ET AL.
ANNALS OF NEUROLOGY vol. 26, no. 2, August 1989, BOSTON,MA,USA pages 210 - 215 S. KHATOON ET AL. cited in the application
NEUROSCIENCE LETTERS vol. 130, 1991, IRELAND pages 89 - 91 S.SYRJ[NEN ET AL.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 88, December 1991, WASHINGTON US pages 10540 - 10543 C.D.SMITH ET AL.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 89, December 1992, WASHINGTON US pages 11949 - 11953 D.GUNNERSEN ET AL.
Download PDF: