Title:
DETECTION OF CANCER CELLS IN BODY FLUIDS
Document Type and Number:
WIPO Patent Application WO2006031843
Kind Code:
A3
Abstract:
A method of detecting circulating melanoma or carcinoma cells in a subject. The method comprises obtaining a body fluid from a subject and detecting the expression of a panel of genes in the body fluid, wherein the expression of the panel of genes indicates the presence of circulating melanoma or carcinoma cells in the subject. Genes useful for detecting melanoma cells includes Ga1NAc-T, MAGE-A3, MART-1, PAX-3, and TRP-2; genes useful for detecting carcinoma cells include C-Met, MAGE-A3, Stanniocalcin-1, Stanniocalcin-2, mammaglobin, HSP27, Ga1NAc-T, CK20, and ß-HCG. Also disclosed are kits containing agents for detecting the expression of these genes.
Inventors:
HOON DAVE S B (US)
Application Number:
PCT/US2005/032631
Publication Date:
October 19, 2006
Filing Date:
September 14, 2005
Export Citation:
Assignee:
WAYNE JOHN CANCER INST (US)
HOON DAVE S B (US)
HOON DAVE S B (US)
International Classes:
C12Q1/68; C07H21/04; C12P19/34
Other References:
GRADILONE A. ET AL.: "Detection of CK19, CK20, and EGFR mRNAs in Peripheral Blood of Carcinoma Patients: Correlation with Clinical Stage of Disease", ONCOLOGY REPORTS, vol. 10, 2003, pages 217 - 222, XP002389050
MARCHETTI A. ET AL.: "mRNA Markers of Breast Cancer Nodal Metastases Comparison between Mammaglobin and Carcioembryonic Antigen in 248 Patients", J.PATHOL., vol. 195, 2001, pages 186 - 190, XP008117721
TABACK ET AL.: "Detection of Occult Metastic Breast Cancer Cells in Blood by a Multimolecular Marker Assay: Correlation with Clinical Stages of Disease", CANCER RESEARCH, vol. 61, 15 December 2001 (2001-12-15), pages 8845 - 8850, XP002528901
CHANG ET AL.: "Mammalian Stanniocalcins and Cancer", ENDOCRINE-RELATED CANCER, vol. 10, 2003, pages 359 - 373, XP008117722
PENG H. ET AL.: "Multiple PCR Analyses on Trace Amounts of DNA ectracted from fresh and parafin wax, embedded tissues after random heaxmer primer PCR amplification", J.CLIN.PATHOLOGY, vol. 47, 1994, pages 605 - 608, XP008117741
PALMIERI ET AL.: "Detection od Occult Melanoma Cells in Parafinn-Embedded Histologically Negative Sentinel Lymph Nodes Using a Reverse Transcriptase Polymerase Chain Reaction Assay", J. CLIN. ONCOLOGY, vol. 19, no. 5, 1 March 2001 (2001-03-01), pages 1437 - 1443, XP002320654
KUO ET AL.: "Assessment of Messenger RNA of Acetylgalactosaminyltransderase as a Molecular Marker for Metastic Melanoma", CLINICAL CANCER RESEARCH, vol. 4, February 1998 (1998-02-01), pages 411 - 418, XP003012801
SHCOLL F. ET AL.: "PAX-3 in Expressed in Human Melanomas and Contributes to Tumor Cell Survival", CANCER RESEARCH, vol. 61, February 2001 (2001-02-01), pages 823 - 826, XP008117723
COULIE P. ET AL.: "A moncolon cytolytic T-hymphocyte response ovserved in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-A3", PNAS, vol. 98, no. 18, 28 August 2001 (2001-08-28), XP002447303
See also references of EP 1799857A4
MARCHETTI A. ET AL.: "mRNA Markers of Breast Cancer Nodal Metastases Comparison between Mammaglobin and Carcioembryonic Antigen in 248 Patients", J.PATHOL., vol. 195, 2001, pages 186 - 190, XP008117721
TABACK ET AL.: "Detection of Occult Metastic Breast Cancer Cells in Blood by a Multimolecular Marker Assay: Correlation with Clinical Stages of Disease", CANCER RESEARCH, vol. 61, 15 December 2001 (2001-12-15), pages 8845 - 8850, XP002528901
CHANG ET AL.: "Mammalian Stanniocalcins and Cancer", ENDOCRINE-RELATED CANCER, vol. 10, 2003, pages 359 - 373, XP008117722
PENG H. ET AL.: "Multiple PCR Analyses on Trace Amounts of DNA ectracted from fresh and parafin wax, embedded tissues after random heaxmer primer PCR amplification", J.CLIN.PATHOLOGY, vol. 47, 1994, pages 605 - 608, XP008117741
PALMIERI ET AL.: "Detection od Occult Melanoma Cells in Parafinn-Embedded Histologically Negative Sentinel Lymph Nodes Using a Reverse Transcriptase Polymerase Chain Reaction Assay", J. CLIN. ONCOLOGY, vol. 19, no. 5, 1 March 2001 (2001-03-01), pages 1437 - 1443, XP002320654
KUO ET AL.: "Assessment of Messenger RNA of Acetylgalactosaminyltransderase as a Molecular Marker for Metastic Melanoma", CLINICAL CANCER RESEARCH, vol. 4, February 1998 (1998-02-01), pages 411 - 418, XP003012801
SHCOLL F. ET AL.: "PAX-3 in Expressed in Human Melanomas and Contributes to Tumor Cell Survival", CANCER RESEARCH, vol. 61, February 2001 (2001-02-01), pages 823 - 826, XP008117723
COULIE P. ET AL.: "A moncolon cytolytic T-hymphocyte response ovserved in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-A3", PNAS, vol. 98, no. 18, 28 August 2001 (2001-08-28), XP002447303
See also references of EP 1799857A4
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