Title:
DETECTION OF HUMAN HEPATITIS B VIRUS SURFACE ANTIGEN MUTANTS BY SPECIFIC AMPLIFICATION AND ITS APPLICATION ON GENE CHIP
Document Type and Number:
WIPO Patent Application WO2001007652
Kind Code:
A3
Abstract:
Novel DNA probe sequences for detection, by polymerase chain reaction, of human hepatitis B virus surface antigen mutant 145 (Glycine to Arginine) from serum samples. As a direct application, these specific DNA probes are immobilized on solid glass supports (gene chip) for detection of human hepatitis B virus surface antigen mutant 145 (Glycine to Arginine) by fluorescence.
Inventors:
OON CHONG-JIN
CHEN WEI-NING
LEONG AI-LIN
KOH SHIUAN
CHEN WEI-NING
LEONG AI-LIN
KOH SHIUAN
Application Number:
PCT/IB2000/001079
Publication Date:
December 20, 2001
Filing Date:
July 28, 2000
Export Citation:
Assignee:
GOVERNMENT OF THE REPUBLIC OF (SG)
International Classes:
C12Q1/68; C12Q1/70; (IPC1-7): C12Q1/70; C12Q1/68
Domestic Patent References:
| WO1995011307A1 | 1995-04-27 | |||
| WO1993013120A1 | 1993-07-08 | |||
| WO1996040996A1 | 1996-12-19 |
Foreign References:
| EP0020251A2 | 1980-12-10 | |||
| US5629153A | 1997-05-13 |
Other References:
DATABASE GENBANK NCBI; 24 May 1999 (1999-05-24), IRELAND ET AL.: "Reactivity of in vitro expressed hepatitis B surface antigen variants in commercial diagnostic assays", XP002174852
PULT ET AL.: "A Hepatitis B Virus Mutant With a New Hepatocyte Nuclear Factor1 Binding Site Emerging in Transplant-Transmitted Fulminant Hepatitis B", HEPATOLOGY, vol. 25, no. 6, 1997, pages 1507 - 1515, XP000872066
WANDS ET AL.: "Molecular Pathogenesis of liver disease during persistent hepatitis B virus infection", SEMINARS IN LIVER DISEASE, vol. 12, no. 3, 1992, pages 252 - 264, XP001015778
CARIANI ET AL.: "Emergence of Hepatitis Virus S Gene Mutant in a Liver Transplant Recipient", JOURNAL OF MEDICAL VIROLOGY, vol. 47, 1995, pages 410 - 415, XP002072493
CHIOU ET AL.: "Altered antigenicity of 'a' determinant variants of hepatitis B virus", JOURNAL OF GENERAL VIROLOGY, vol. 78, 1997, pages 2639 - 2645, XP002174817
OGATA ET AL.: "Infectivity and Pathogenicity in Chimpanzees of a Surface Gene Mutant of Hepatitis B Virus that Emerged in a Vaccinated Infant", THE JOURNAL OF INFECTIOUS DISEASES, vol. 175, 1997, pages 511 - 523, XP001015784
HSU ET AL.: "Surface Gene Mutants of Hepatitis B Virus in Infants Who Develop Acute or Chronic Infections Despite Immunoprophylaxis", HEPATOLOGY, vol. 26, no. 3, 1997, pages 786 - 791, XP001015747
PULT ET AL.: "A Hepatitis B Virus Mutant With a New Hepatocyte Nuclear Factor1 Binding Site Emerging in Transplant-Transmitted Fulminant Hepatitis B", HEPATOLOGY, vol. 25, no. 6, 1997, pages 1507 - 1515, XP000872066
WANDS ET AL.: "Molecular Pathogenesis of liver disease during persistent hepatitis B virus infection", SEMINARS IN LIVER DISEASE, vol. 12, no. 3, 1992, pages 252 - 264, XP001015778
CARIANI ET AL.: "Emergence of Hepatitis Virus S Gene Mutant in a Liver Transplant Recipient", JOURNAL OF MEDICAL VIROLOGY, vol. 47, 1995, pages 410 - 415, XP002072493
CHIOU ET AL.: "Altered antigenicity of 'a' determinant variants of hepatitis B virus", JOURNAL OF GENERAL VIROLOGY, vol. 78, 1997, pages 2639 - 2645, XP002174817
OGATA ET AL.: "Infectivity and Pathogenicity in Chimpanzees of a Surface Gene Mutant of Hepatitis B Virus that Emerged in a Vaccinated Infant", THE JOURNAL OF INFECTIOUS DISEASES, vol. 175, 1997, pages 511 - 523, XP001015784
HSU ET AL.: "Surface Gene Mutants of Hepatitis B Virus in Infants Who Develop Acute or Chronic Infections Despite Immunoprophylaxis", HEPATOLOGY, vol. 26, no. 3, 1997, pages 786 - 791, XP001015747
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