Title:
DETECTION OF HUMAN RETROVIRUS INFECTION DETECTION OF HUMAN RETROVIRUS INFECTION
Document Type and Number:
WIPO Patent Application WO1996014437
Kind Code:
A3
Abstract:
A method for determining virus replication in human cells by human retrovirus using RNA amplification comprising detecting the hybridization of an RNA probe which specifically hybridizes with spliced RNA and not with genomic RNA. This method permits early detection of RNA replication resulting from primary infection without detecting non-replicating virus.
Inventors:
ROMANO JOSEPH W (US)
PAL RANAJIT (US)
PAL RANAJIT (US)
Application Number:
PCT/US1995/014850
Publication Date:
August 15, 1996
Filing Date:
November 01, 1995
Export Citation:
Assignee:
AKZO NOBEL NV (NL)
ROMANO JOSEPH W (NL)
PAL RANAJIT (NL)
ROMANO JOSEPH W (NL)
PAL RANAJIT (NL)
International Classes:
C12N15/09; C12Q1/68; C12Q1/70; (IPC1-7): C12Q1/70; C12Q1/68
Domestic Patent References:
| WO1994000598A1 | 1994-01-06 | |||
| WO1993023574A1 | 1993-11-25 | |||
| WO1994019491A1 | 1994-09-01 |
Foreign References:
| EP0569272A1 | 1993-11-10 |
Other References:
ARENS ET AL.: "Alterations in spliced and unspliced HIV-1-specific RNA detection in peripheral blood mononuclear cells of individuals with varying CD4-positive lymphocyte counts.", AIDS RESEARCH AND HUMAN RETROVIRUSES, (1993 DEC) 9 (12), XP000567015
LEWIS ET AL.: "Detection and significance of HIV sequences in HIV infection", PROG. MED. VIROL., vol. 40, 1993, pages 19 - 47, XP002000193
MEYLAN ET AL.: "Mechanisms for the inhibition of HIV replication by Interferons in primary human macrophages", VIROLOGY, vol. 193, 1993, ORLANDO US, pages 138 - 148, XP002000194
LEWIS ET AL.: "Detection and significance of HIV sequences in HIV infection", PROG. MED. VIROL., vol. 40, 1993, pages 19 - 47, XP002000193
MEYLAN ET AL.: "Mechanisms for the inhibition of HIV replication by Interferons in primary human macrophages", VIROLOGY, vol. 193, 1993, ORLANDO US, pages 138 - 148, XP002000194
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