Title:
DETECTION OF MALIGNANT TUMOR CELLS ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/143506
Kind Code:
A1
Abstract:
Provided are anti-ROR2 antibodies and the uses thereof. Provided are anti-ROR2 antibodies and the uses thereof. The anti-ROR2 antibodies have CSASSS VSYMHWYQ, IYDTSKLAS and CQQWSSNPPTFGAG amino acid sequences of a light-chain variable region, as well as YTITSY LMHWV, LEWIGYINPYNDGTKYNEKFKDKAT and CARSDVYYGVRFAYWGQG amino acid sequences of a heavy-chain variable region. Alternatively, the antibodies have CKASQNVGTNVAWFQ, IYLASYRYS and CQQYNSYPLTFGGG amino acid sequences of the light-chain variable region, as well as YTFTNYWIQWM, LEWIGEINPSNGRTDYNEKFKNRAT and CANYRPGYWGQG amino acid sequences of the heavy-chain variable region.
Inventors:
ZHANG SUPING (CN)
KIPPS THOMAS JAMES (CN)
WU LIUFENG (CN)
KIPPS THOMAS JAMES (CN)
WU LIUFENG (CN)
Application Number:
PCT/CN2019/130486
Publication Date:
July 16, 2020
Filing Date:
December 31, 2019
Export Citation:
Assignee:
UNIV SHENZHEN (CN)
International Classes:
C07K16/28; A61K47/68; A61P35/00
Domestic Patent References:
| WO2016142768A1 | 2016-09-15 | |||
| WO2017197234A1 | 2017-11-16 |
Foreign References:
| CN108699149A | 2018-10-23 | |||
| CN107847596A | 2018-03-27 |
Other References:
MA, S.S.Q. ET AL.: "Validation of specificity of antibodies for immunohistochemistry: the case of ROR2", VIRCHOWSARCH, vol. 470, no. 1, 8 September 2016 (2016-09-08), pages 99 - 108, XP036136648
EDRIS, B. ET AL.: "ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour", JOURNAL OF PATHOLOGY, vol. 227, no. 2, 31 December 2012 (2012-12-31), pages 223 - 233, XP055200350
LI, RUIYAN; HU, YANNI; GU, XIAOYAN; XU, YOUHUA: "Expression and mechanism of Frizzled/LRP and ROR2 receptor in leukemia cells", CHINESE JOURNAL OF CLINICAL ONCOLOGY, vol. 38, no. 11, 31 December 2011 (2011-12-31), pages 612 - 616, XP009522382, DOI: 10.3969/j.issn.1000-8179.2011.11.004
See also references of EP 3936523A4
EDRIS, B. ET AL.: "ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour", JOURNAL OF PATHOLOGY, vol. 227, no. 2, 31 December 2012 (2012-12-31), pages 223 - 233, XP055200350
LI, RUIYAN; HU, YANNI; GU, XIAOYAN; XU, YOUHUA: "Expression and mechanism of Frizzled/LRP and ROR2 receptor in leukemia cells", CHINESE JOURNAL OF CLINICAL ONCOLOGY, vol. 38, no. 11, 31 December 2011 (2011-12-31), pages 612 - 616, XP009522382, DOI: 10.3969/j.issn.1000-8179.2011.11.004
See also references of EP 3936523A4
Attorney, Agent or Firm:
CENFO INTELLECTUAL PROPERTY AGENCY (CN)
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