Title:
DETECTION METHOD FOR RHEUMATOID ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2021/246505
Kind Code:
A1
Abstract:
Provides is a more useful novel biomarker with which rheumatoid arthritis can be simply and accurately detected, in particular, a biomarker with which rheumatoid arthritis can be diagnosed at an early stage. In a diagnostic method for rheumatoid arthritis according to the present invention, acrolein in a sample collected from a subject is measured.
Inventors:
NISHIMURA KEITA (JP)
SHIOKAWA KOICHIRO (JP)
IGARASHI KAZUEI (JP)
SHIOKAWA KOICHIRO (JP)
IGARASHI KAZUEI (JP)
Application Number:
PCT/JP2021/021306
Publication Date:
December 09, 2021
Filing Date:
June 04, 2021
Export Citation:
Assignee:
UNIV TEIKYO (JP)
International Classes:
G01N33/53; G01N33/50; G01N33/68
Domestic Patent References:
| WO2006127695A2 | 2006-11-30 |
Foreign References:
| JP2013527437A | 2013-06-27 | |||
| JP2007101488A | 2007-04-19 | |||
| JP2018054434A | 2018-04-05 |
Other References:
SAOTOME, TAKATOSHI: "Level of plasma acrolein in patients with rheumatoid arthritis", LECTURE ABSTRACTS OF 8TH ANNUAL CONFERENCE OF THE JAPANESE SOCIETY OF POLYAMINE RESEARCH, vol. 8th, 20 January 2017 (2017-01-20), pages 27
LUCZAJ, WOJCIECH: "The onset of lipid peroxidation in rheumatoid arthritis: consequences and monitoring", FREE RADICAL RESEARCH, vol. 50, no. 3, 14 January 2016 (2016-01-14), pages 304 - 313, XP055879683
LUCZAJ, WOJCIECH: "Lipid peroxidation in Rheumatoid arthritis; consequences and monitoring", FREE RADICAL BIOLOGY & MEDICINE, vol. 75, no. 1, 10 December 2014 (2014-12-10), pages S49, XP055879689
KAWABATA, CHISATO: "Plasma acrolein level in rheumatoid arthritis increases independently of the disease characteristics", MODERN RHEUMATOLOGY, vol. 31, no. 2, 16 June 2020 (2020-06-16), pages 357 - 364, XP055879700
KISHIKAWA, NAOYA: "Development of derivatized HPLC quantification method of lipid peroxide aiming for an evaluation of oxidative stress", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, vol. 48, no. 1, 28 August 2019 (2019-08-28), pages 155
KISHIKAWA, NAOYA: "Drug treatments changed by advances in clinical chemistry : Development of a new evaluation method for oxidative stress diseases using lipid peroxidation aldehyde as a marker", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, vol. 46, no. 4, 31 October 2017 (2017-10-31), pages 299 - 304
EL-MAGHRABEY, MAHMOUD H.: "Analytical method for lipoperoxidation relevant reactive aldehydes in human sera by high-performance liquid chromatography-fluorescence detection", ANALYTICAL BIOCHEMISTRY, vol. 464, 1 November 2014 (2014-11-01), pages 36 - 42, XP029064022, DOI: 10.1016/j.ab.2014.07.002
ALI MARWA FATHY BAKR; KISHIKAWA NAOYA; OHYAMA KANAME; MOHAMED HORRIA ABDEL-MAGEED; ABDEL-WADOOD HANAA MOHAMED; MAHMOUD ASHRAF MOHA: "Chromatographic determination of low-molecular mass unsaturated aliphatic aldehydes with peroxyoxalate chemiluminescence detection after fluorescence labeling with 4-(N,N-dimethylaminosulfonyl)-7- hydrazino-2, 1,3-benzoxadiazole", JOURNAL OF CHROMATOGRAPHY B, vol. 953, no. 95, 15 March 2014 (2014-03-15), pages 147 - 152, XP028633222
LUCZAJ, WOJCIECH: "The onset of lipid peroxidation in rheumatoid arthritis: consequences and monitoring", FREE RADICAL RESEARCH, vol. 50, no. 3, 14 January 2016 (2016-01-14), pages 304 - 313, XP055879683
LUCZAJ, WOJCIECH: "Lipid peroxidation in Rheumatoid arthritis; consequences and monitoring", FREE RADICAL BIOLOGY & MEDICINE, vol. 75, no. 1, 10 December 2014 (2014-12-10), pages S49, XP055879689
KAWABATA, CHISATO: "Plasma acrolein level in rheumatoid arthritis increases independently of the disease characteristics", MODERN RHEUMATOLOGY, vol. 31, no. 2, 16 June 2020 (2020-06-16), pages 357 - 364, XP055879700
KISHIKAWA, NAOYA: "Development of derivatized HPLC quantification method of lipid peroxide aiming for an evaluation of oxidative stress", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, vol. 48, no. 1, 28 August 2019 (2019-08-28), pages 155
KISHIKAWA, NAOYA: "Drug treatments changed by advances in clinical chemistry : Development of a new evaluation method for oxidative stress diseases using lipid peroxidation aldehyde as a marker", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, vol. 46, no. 4, 31 October 2017 (2017-10-31), pages 299 - 304
EL-MAGHRABEY, MAHMOUD H.: "Analytical method for lipoperoxidation relevant reactive aldehydes in human sera by high-performance liquid chromatography-fluorescence detection", ANALYTICAL BIOCHEMISTRY, vol. 464, 1 November 2014 (2014-11-01), pages 36 - 42, XP029064022, DOI: 10.1016/j.ab.2014.07.002
ALI MARWA FATHY BAKR; KISHIKAWA NAOYA; OHYAMA KANAME; MOHAMED HORRIA ABDEL-MAGEED; ABDEL-WADOOD HANAA MOHAMED; MAHMOUD ASHRAF MOHA: "Chromatographic determination of low-molecular mass unsaturated aliphatic aldehydes with peroxyoxalate chemiluminescence detection after fluorescence labeling with 4-(N,N-dimethylaminosulfonyl)-7- hydrazino-2, 1,3-benzoxadiazole", JOURNAL OF CHROMATOGRAPHY B, vol. 953, no. 95, 15 March 2014 (2014-03-15), pages 147 - 152, XP028633222
Attorney, Agent or Firm:
YAMAGUCHI Kenjiro et al. (JP)
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