Title:
DETERMINATION OF MODIFICATION DEGREE OF THERAPEUTIC PROTEINS USING 1H-NMR SPECTROSCOPY
Document Type and Number:
WIPO Patent Application WO/2021/172326
Kind Code:
A1
Abstract:
This invention provides, among other things, methods for determining the average number of first polymers covalently attached to protein-first polymer conjugates in a solution.
Inventors:
FARCET JEAN-BAPTISTE (AT)
SIEKMANN JUERGEN (AT)
SIEKMANN JUERGEN (AT)
Application Number:
PCT/JP2021/006782
Publication Date:
September 02, 2021
Filing Date:
February 24, 2021
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
G01N24/08
Domestic Patent References:
| WO2012108297A1 | 2012-08-16 |
Foreign References:
| US20060154323A1 | 2006-07-13 |
Other References:
ZAGHMI AHLEM, ANDREA A. GRESCHNER, EDUARDO MENDEZ-VILLUENDAS, JUN YANG LIU, HENDRICK W. DE HAAN, MARC A. GAUTHIER: "Determination of the degree of PEGylation of protein bioconjugates using data from proton nuclear magnetic resonance spectroscopy", DATA IN BRIEF, vol. 25, 23 May 2019 (2019-05-23), XP055841004, DOI: 10.1016/j.dib.2019.104037
See also references of EP 4111185A4
See also references of EP 4111185A4
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (JP)
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