Title:
DETERMINATION OF THE RECEPTIVE STATUS OF THE ENDOMETRIUM
Document Type and Number:
WIPO Patent Application WO/2018/096375
Kind Code:
A3
Abstract:
The invention relates to a method for determining the receptive or non-receptive status of the endometrium using a biological sample from a subject of reproductive age, preferably from a human female patient. Moreover, the invention relates to a test kit suitable for performing the method, as well as the use of oligonucleotides suitable for the amplification of gene sets for the determination of the receptive or non- receptive status of the endometrium.
Inventors:
BÁLINT BÁLINT LÁSZLÓ (HU)
Application Number:
PCT/HU2017/050049
Publication Date:
October 04, 2018
Filing Date:
November 22, 2017
Export Citation:
Assignee:
QUANTBIO KFT (HU)
International Classes:
A61B17/435; C12Q1/6883; A61D19/04; C12Q1/6837
Domestic Patent References:
| WO2013135836A1 | 2013-09-19 |
Foreign References:
| EP2348318A1 | 2011-07-27 |
Other References:
MARIA RUIZ-ALONSO ET AL: "The genomics of the human endometrium", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE., vol. 1822, no. 12, 1 December 2012 (2012-12-01), NL, pages 1931 - 1942, XP055471229, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2012.05.004
TALBI S ET AL: "Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women", ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 147, no. 3, 1 March 2006 (2006-03-01), pages 1097 - 1121, XP002595772, ISSN: 0013-7227, [retrieved on 20060301], DOI: 10.1210/EN.2005-1076
ANNA P. PONNAMPALAM ET AL: "Molecular classification of human endometrial cycle stages by transcriptional profiling", MOLECULAR HUMAN REPRODUCTION., vol. 10, no. 12, 1 December 2004 (2004-12-01), GB - BE, pages 879 - 893, XP055471232, ISSN: 1360-9947, DOI: 10.1093/molehr/gah121
GIUDICE LINDA C: "Application of functional genomics to primate endometrium: insights into biological processes", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, vol. 4, no. Suppl 1, S4, 9 October 2006 (2006-10-09), XP021024770, ISSN: 1477-7827, DOI: 10.1186/1477-7827-4-S1-S4
DIAZ-GIMENO P ET AL: "A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature", FERTILITY AND STERILITY, vol. 95, no. 1, 1 January 2011 (2011-01-01), pages 50 - 60.e15, XP027563196, ISSN: 0015-0282, [retrieved on 20100708]
ALISON S. DEVONSHIRE ET AL: "Application of next generation qPCR and sequencing platforms to mRNA biomarker analysis", METHODS, vol. 59, no. 1, 1 January 2013 (2013-01-01), US, pages 89 - 100, XP055228123, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2012.07.021
ZEYNEP H GUMUS: "Wafergen Biosystems SmartChip Human Oncology Panel v2", 1 July 2012 (2012-07-01), pages 1 - 31, XP055495306, Retrieved from the Internet [retrieved on 20180725]
DELPHINE HAOUZI ET AL: "Insights into human endometrial receptivity from transcriptomic and proteomic data", REPRODUCTIVE BIOMEDICINE ONLINE, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 1, 15 September 2011 (2011-09-15), pages 23 - 34, XP028122046, ISSN: 1472-6483, [retrieved on 20110929], DOI: 10.1016/J.RBMO.2011.09.009
VILELLA F ET AL: "Endometrial fluid transcriptomics as a new non-invasive diagnostic method of uterine receptivity", FERTILITY AND STERILITY, vol. 108, no. 3, 31 October 2017 (2017-10-31), XP085158410, ISSN: 0015-0282, DOI: 10.1016/J.FERTNSTERT.2017.07.156
TALBI S ET AL: "Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women", ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 147, no. 3, 1 March 2006 (2006-03-01), pages 1097 - 1121, XP002595772, ISSN: 0013-7227, [retrieved on 20060301], DOI: 10.1210/EN.2005-1076
ANNA P. PONNAMPALAM ET AL: "Molecular classification of human endometrial cycle stages by transcriptional profiling", MOLECULAR HUMAN REPRODUCTION., vol. 10, no. 12, 1 December 2004 (2004-12-01), GB - BE, pages 879 - 893, XP055471232, ISSN: 1360-9947, DOI: 10.1093/molehr/gah121
GIUDICE LINDA C: "Application of functional genomics to primate endometrium: insights into biological processes", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, vol. 4, no. Suppl 1, S4, 9 October 2006 (2006-10-09), XP021024770, ISSN: 1477-7827, DOI: 10.1186/1477-7827-4-S1-S4
DIAZ-GIMENO P ET AL: "A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature", FERTILITY AND STERILITY, vol. 95, no. 1, 1 January 2011 (2011-01-01), pages 50 - 60.e15, XP027563196, ISSN: 0015-0282, [retrieved on 20100708]
ALISON S. DEVONSHIRE ET AL: "Application of next generation qPCR and sequencing platforms to mRNA biomarker analysis", METHODS, vol. 59, no. 1, 1 January 2013 (2013-01-01), US, pages 89 - 100, XP055228123, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2012.07.021
ZEYNEP H GUMUS: "Wafergen Biosystems SmartChip Human Oncology Panel v2", 1 July 2012 (2012-07-01), pages 1 - 31, XP055495306, Retrieved from the Internet
DELPHINE HAOUZI ET AL: "Insights into human endometrial receptivity from transcriptomic and proteomic data", REPRODUCTIVE BIOMEDICINE ONLINE, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 1, 15 September 2011 (2011-09-15), pages 23 - 34, XP028122046, ISSN: 1472-6483, [retrieved on 20110929], DOI: 10.1016/J.RBMO.2011.09.009
VILELLA F ET AL: "Endometrial fluid transcriptomics as a new non-invasive diagnostic method of uterine receptivity", FERTILITY AND STERILITY, vol. 108, no. 3, 31 October 2017 (2017-10-31), XP085158410, ISSN: 0015-0282, DOI: 10.1016/J.FERTNSTERT.2017.07.156
Attorney, Agent or Firm:
DANUBA PATENT AND LAW OFFICE LLC. (HU)
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