Title:
DEUTERATED 2-ARYLHETEROCYCLE-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/111708
Kind Code:
A1
Abstract:
The present invention relates to a deuterated 3-oxo-2,3-dihydropyridazine-4-carboxamide inhibitor, a preparation method therefor, and an application thereof. Specifically, the compound of the present invention has the structure shown in formula (I); also disclosed in the present invention are a preparation method for said compound and the use thereof as an AhR inhibitor; the compound of the present invention has a good selective inhibitory effect on AhR, and has better pharmacodynamics, pharmacokinetic properties, and lower toxic side effects.
Inventors:
LV BINHUA (CN)
CUI DAWEI (CN)
LIU LIANJUN (CN)
PANG XUDONG (CN)
CHAI CHUANKE (CN)
CUI DAWEI (CN)
LIU LIANJUN (CN)
PANG XUDONG (CN)
CHAI CHUANKE (CN)
Application Number:
PCT/CN2021/134146
Publication Date:
June 02, 2022
Filing Date:
November 29, 2021
Export Citation:
Assignee:
SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
International Classes:
C07D401/14; A61K31/501; A61P35/00; C07D417/04
Foreign References:
| CN110678459A | 2020-01-10 |
Other References:
WANG XI, DU YUNFE: "Research Progress on Deuterated Drugs", TIANJIN YAOXUE =TIANJIN PHARMACY, TIANJIN YAOXUE, CHINA, vol. 32, no. 1, 26 August 2020 (2020-08-26), China , pages 44 - 56, XP055933229, ISSN: 1006-5687
XUEYING LI, JIA FEI, WEIBO ZHANG: "A dvances in Patented Technologies of Deuterated Drugs", PROGRESS IN PHARMACEUTICAL SCIENCES, CHINA PHARMACEUTICAL UNIVERSITY, CN, vol. 41, 31 December 2017 (2017-12-31), CN , pages 833 - 845, XP055933235, ISSN: 1001-5094
"Handbook of Chemistry and Physics", article "Periodic Table of the Elements"
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
XUEYING LI, JIA FEI, WEIBO ZHANG: "A dvances in Patented Technologies of Deuterated Drugs", PROGRESS IN PHARMACEUTICAL SCIENCES, CHINA PHARMACEUTICAL UNIVERSITY, CN, vol. 41, 31 December 2017 (2017-12-31), CN , pages 833 - 845, XP055933235, ISSN: 1001-5094
"Handbook of Chemistry and Physics", article "Periodic Table of the Elements"
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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