DEUTERATED 3-QUINUCLIDONE COMPOUND, PREPARATION METHOD, AND USE

Title:

DEUTERATED 3-QUINUCLIDONE COMPOUND, PREPARATION METHOD, AND USE

Document Type and Number:

WIPO Patent Application WO/2019/015690

Kind Code:

A1

Abstract:

A deuterated 3-quinuclidone compound, a preparation method, and a use. In particular, the present invention provides a compound shown in general formula I or a pharmaceutically acceptable salt, isomer or a mixture thereof, solvate, polymorph, stable isotopic derivative, or prodrug thereof and a preparation method and pharmaceutical application of the same. The deuterated 3-quinuclidone compound has excellent pharmacokinetic properties and antitumor activity. (I)

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Inventors:

ZHANG FUYAO (CN)
YUAN HONGSHUN (CN)
SHEN XIAOMING (CN)

Application Number:

PCT/CN2018/096619

Publication Date:

January 24, 2019

Filing Date:

July 23, 2018

Export Citation:

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Assignee:

SELECTION BIOSCIENCE LLC (CN)

International Classes:

C07D453/02; A61K31/439; A61P35/00; C07B59/00

Domestic Patent References:

WO2005090341A1	2005-09-29
WO2004084893A1	2004-10-07
WO2002024692A1	2002-03-28

Foreign References:

CN104003925A

2014-08-27

Other References:

JIANG, WENFENG ET AL.: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 31 December 2010 (2010-12-31), pages 682 - 684, XP008173943

Attorney, Agent or Firm:

SHANGHAI BESHINING LAW OFFICE (CN)

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