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Title:
DEUTERATED DEFACTINIB COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/214587
Kind Code:
A1
Abstract:
Provided are a compound as shown in formula (I) or optical isomers, pharmaceutically acceptable salts, hydrates or solvates thereof, wherein R 1-R 18 are independently selected from hydrogen and deuterium respectively, and same are not all hydrogen. The compound and salts, hydrates or solvates thereof can be used as FAK inhibitors, and used in the preparation of anti-cancer drugs, and compared with the undeuterated control compound Defactinib, the compound has significantly improved metabolic stability and pharmacokinetic properties, while also possessing good application prospects.

Inventors:
DU, Wu (No.1, 4rd Floor RongYao Building A, 5 Keyuan South Road, High-Tech Zone, Chengdu Sichuan 1, 610041, CN)
LI, Yu (No.1, 4rd Floor RongYao Building A, 5 Keyuan South Road, High-Tech Zone, Chengdu Sichuan 1, 610041, CN)
WEN, Kun (No.1, 4rd Floor RongYao Building A, 5 Keyuan South Road, High-Tech Zone, Chengdu Sichuan 1, 610041, CN)
LI, Xinghai (No.1, 4rd Floor RongYao Building A, 5 Keyuan South Road, High-Tech Zone, Chengdu Sichuan 1, 610041, CN)
CHEN, Yuanwei (No.1, 4rd Floor RongYao Building A, 5 Keyuan South Road, High-Tech Zone, Chengdu Sichuan 1, 610041, CN)
Application Number:
CN2019/085722
Publication Date:
November 14, 2019
Filing Date:
May 06, 2019
Export Citation:
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Assignee:
HINOVA PHARMACEUTICALS INC. (No.1, 4rd Floor RongYao Building A, 5 Keyuan South Road, High-Tech Zone, Chengdu Sichuan 1, 610041, CN)
International Classes:
C07D403/12; A61K31/506; A61P35/00
Domestic Patent References:
WO2008129380A12008-10-30
WO2010144499A22010-12-16
Foreign References:
CN106146406A2016-11-23
US20110053968A12011-03-03
Other References:
ZHANG, YINSHENG: "Development of Deuterated Drugs: Past, Present and Future", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 41, no. 12, 31 December 2017 (2017-12-31), pages 902 - 918
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (The Yiguanmiao Post Office Box A-42, Hi-Tech ZoneChengdu, Sichuan 1, 610041, CN)
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