Title:
DEUTERATED NICLOSAMIDE
Document Type and Number:
WIPO Patent Application WO/2021/142238
Kind Code:
A1
Abstract:
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that exhibit activity as mitochondrial uncoupling agents. Said chemical entities are useful, e.g., for treating one or more symptoms of a pathology characterized by an abnormal inflammatory response (e.g., inflammatory bowel diseases) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.
Inventors:
GLICK GARY D (US)
Application Number:
PCT/US2021/012673
Publication Date:
July 15, 2021
Filing Date:
January 08, 2021
Export Citation:
Assignee:
FIRST WAVE BIO INC (US)
GLICK GARY D (US)
GLICK GARY D (US)
International Classes:
A61P31/04; A61K31/609; C07B59/00
Domestic Patent References:
| WO2017048197A1 | 2017-03-23 | |||
| WO2014023329A1 | 2014-02-13 | |||
| WO2018191776A1 | 2018-10-25 | |||
| WO2018213834A1 | 2018-11-22 | |||
| WO1991013281A1 | 1991-09-05 | |||
| WO2004006906A2 | 2004-01-22 | |||
| WO2006120178A1 | 2006-11-16 | |||
| WO2012143377A1 | 2012-10-26 | |||
| WO2012068274A1 | 2012-05-24 | |||
| WO2017040864A1 | 2017-03-09 |
Foreign References:
| US202062990414P | 2020-03-16 | |||
| US202062993688P | 2020-03-23 | |||
| US202063002324P | 2020-03-30 | |||
| US20120202848A1 | 2012-08-09 | |||
| US20130231312A1 | 2013-09-05 | |||
| US7927613B2 | 2011-04-19 | |||
| US10292951B2 | 2019-05-21 | |||
| US9192583B2 | 2015-11-24 | |||
| US6224910B1 | 2001-05-01 | |||
| US5914132A | 1999-06-22 | |||
| US9237760B2 | 2016-01-19 | |||
| US9023368B2 | 2015-05-05 | |||
| US6228396B1 | 2001-05-08 | |||
| US10588864B2 | 2020-03-17 | |||
| US9566399B1 | 2017-02-14 | |||
| US6513727B1 | 2003-02-04 | |||
| US6513519B2 | 2003-02-04 | |||
| US6176237B1 | 2001-01-23 | |||
| US6085741A | 2000-07-11 | |||
| US6000394A | 1999-12-14 | |||
| US5957389A | 1999-09-28 | |||
| US5740966A | 1998-04-21 | |||
| US5549102A | 1996-08-27 | |||
| US5461695A | 1995-10-24 | |||
| US5458136A | 1995-10-17 | |||
| US5312046A | 1994-05-17 | |||
| US5309900A | 1994-05-10 | |||
| US5280784A | 1994-01-25 | |||
| US4496086A | 1985-01-29 | |||
| EP0311863A2 | 1989-04-19 | |||
| EP0516636A1 | 1992-12-09 | |||
| US8148328B2 | 2012-04-03 | |||
| US20090062396A1 | 2009-03-05 | |||
| US7132546B2 | 2006-11-07 | |||
| US7989498B2 | 2011-08-02 | |||
| US8263857B2 | 2012-09-11 |
Other References:
NILSSON GÖRAN N. ET AL: "The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 53, no. 11-12, 1 September 2010 (2010-09-01), GB, pages 662 - 667, XP055789257, ISSN: 0362-4803, DOI: 10.1002/jlcr.1817
LI, Y. ET AL., CANCER LETT., vol. 349, 2014, pages 8 - 14
BLAKE, M I ET AL., J PHARM SCI, vol. 64, 1975, pages 367 - 91
FOSTER, A B, ADV DRUG RES, vol. 14, 1985, pages 1 - 40
FISHER, M B ET AL., CURR OPIN DRUG DISCOV DEVEL, vol. 9, 2006, pages 101 - 09
CONCERT PHARMACEUTICALS ET AL.: "Precision Deuterium Chemistry Backgrounder", 2007, CONCERT PHARMACEUTICALS INC., pages: 1 - 6
INT. J. APPL. RES. NAT. PROD., vol. 5, 2012, pages 1 - 16
HANDBOOK OF PHARMACEUTICAL EXCIPIENTS
THE PHARMACEUTICAL PRESS AND THE AMERICAN PHARMACEUTICAL ASSOCIATION, 2009
"Pharmaceutical Preformulation and Formulation", 2009, CRC PRESS LLC
SANPHUI, P., CRYST. GROWTH DES., vol. 12, 2012, pages 4588
IMRAMOVSKY, A., CRYSTALS, vol. 2, 2012, pages 349 - 361
GRIFASI, F., CRYST. GROWTH DES., vol. 75, 2015, pages 4588
FILIPSKI, K.J. ET AL., CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 13, 2013, pages 776 - 802
AMIDO, AAPS PHARMSCITECH, vol. 16, no. 4, August 2015 (2015-08-01)
AMIDO, AAPSPHARMSCITECH, vol. 16, no. 4, August 2015 (2015-08-01)
CARBOHYDRATE POLYMERS, vol. 92, 2013, pages 367 - 373
J. CONTROLLED RELEASE, vol. 38, 1996, pages 75 - 94
OBACH, R.S., DRUG METAB DISP, vol. 27, 1999, pages 1350
EDITION CANTOR: "Fiedler Encyclopedia of Excipients for Pharmaceuticals, Cosmetics and Related Areas", 2002
R. LAROCK: "Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik and angrenzende Gebiete", 1989, VCH PUBLISHERS
COSTABILE ET AL., MOL PHARM, vol. 12, no. 8, 3 August 2015 (2015-08-03), pages 2604 - 17
BOMMER, R., PHARMACEUTICAL TECHNOLOGY EUROPE, September 1999 (1999-09-01)
LABIRISDOLOVICH, BR J CLIN PHARMACOL, vol. 56, no. 6, December 2003 (2003-12-01), pages 600 - 612
POSTOW, M., J. CLIN. ONCOL., vol. 33, 2015, pages 1
CORMAN ET AL., EUROSURVEILLANCE, vol. 25, 2020, pages 2000045
SENKOWSKI. W., MOL. CANCER THER., vol. J 4, 2015, pages 1504
LIU, CYNTHIA ET AL., RESEARCH AND DEVELOPMENT ON THERAPEUTIC AGENTS AND VACCINES FOR COVID-19 AND RELATED HUMAN CORONAVIRUS DISEASES, 2020
LAI, CHIH-CHENG ET AL.: "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges", INTERNATIONAL J OURNAL OF ANTIMICROBIAL AGENTS, 2020, pages 105924
CHANG, YU-CHUAN ET AL., POTENTIAL THERAPEUTIC AGENTS FOR COVID-19 BASED ON THE ANALYSIS OF PROTEASE AND RNA POLYMERASE DOCKING, 2020
KO WCROLAIN JMLEE NY ET AL.: "Arguments in favor of remdesivir for treating SARS-CoV-2 infections", INT J ANTIMICROB AGENTS, 5 March 2020 (2020-03-05), pages 105933
DHAMA, K. ET AL., CORONAVIRUS DISEASE, 2020
STEBBING, JUSTIN ET AL.: "COVID-19: combining antiviral and anti-inflammatory treatments", THE LANCET INFECTIOUS DISEASES, 2020
YANG, NAIDIHAN-MING SHEN: "Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19", INT J BIOL SCI, vol. 16, no. 10, 2020, pages 1724 - 1731, XP055744881, DOI: 10.7150/ijbs.45498
CASADEVALL, ARTUROLIISE-ANNE PIROFSKI: "The convalescent sera option for containing COVID-19", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 130, no. 4, 2020, XP055724995, DOI: 10.1172/JCI138003
SHANMUGARAJ, BALAMURUGAN ET AL.: "Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19", ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 2020
XU, JIMIN ET AL.: "Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential", ACS INFECTIOUS DISEASES, 2020
GAUTRET ET AL., INT J ANTIMICROB AGENTS, 20 March 2020 (2020-03-20), pages 105949
T. W. GREENERGM. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY AND SONS
HOUSTON, J.B., BIOCHEM PHARMACOL, vol. 47, 1994, pages 1469
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 60, 2016, pages 323
"Antimicrobial Agents and Chemotherapy", vol. 60, 2016, pages: 323
"Remington's Pharmaceutical Sciences", 1980, MACK PUBLISHING CO., pages: 1182
ORG. CHEM. FRONT., vol. 2, 2015, pages 1071 - 1075
J. LABEL COMPD. RADIOPHARM, vol. 53, 2010, pages 662
ORG. BIOMOL. CHEM., vol. 12, 2014, pages 3598
ADV. SYNTH. CATAL., vol. 356, 2014, pages 3551
HOUSTON, J.B. ET AL., DRUG METAB REV, vol. 29, 1997, pages 891
IWATSUBO, T ET AL., PHARMACOL THER, vol. 73, 1997, pages 147
LAVE, T. ET AL., PHARM RES, vol. 14, 1997, pages 152
LI, Y. ET AL., CANCER LETT., vol. 349, 2014, pages 8 - 14
BLAKE, M I ET AL., J PHARM SCI, vol. 64, 1975, pages 367 - 91
FOSTER, A B, ADV DRUG RES, vol. 14, 1985, pages 1 - 40
FISHER, M B ET AL., CURR OPIN DRUG DISCOV DEVEL, vol. 9, 2006, pages 101 - 09
CONCERT PHARMACEUTICALS ET AL.: "Precision Deuterium Chemistry Backgrounder", 2007, CONCERT PHARMACEUTICALS INC., pages: 1 - 6
INT. J. APPL. RES. NAT. PROD., vol. 5, 2012, pages 1 - 16
HANDBOOK OF PHARMACEUTICAL EXCIPIENTS
THE PHARMACEUTICAL PRESS AND THE AMERICAN PHARMACEUTICAL ASSOCIATION, 2009
"Pharmaceutical Preformulation and Formulation", 2009, CRC PRESS LLC
SANPHUI, P., CRYST. GROWTH DES., vol. 12, 2012, pages 4588
IMRAMOVSKY, A., CRYSTALS, vol. 2, 2012, pages 349 - 361
GRIFASI, F., CRYST. GROWTH DES., vol. 75, 2015, pages 4588
FILIPSKI, K.J. ET AL., CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 13, 2013, pages 776 - 802
AMIDO, AAPS PHARMSCITECH, vol. 16, no. 4, August 2015 (2015-08-01)
AMIDO, AAPSPHARMSCITECH, vol. 16, no. 4, August 2015 (2015-08-01)
CARBOHYDRATE POLYMERS, vol. 92, 2013, pages 367 - 373
J. CONTROLLED RELEASE, vol. 38, 1996, pages 75 - 94
OBACH, R.S., DRUG METAB DISP, vol. 27, 1999, pages 1350
EDITION CANTOR: "Fiedler Encyclopedia of Excipients for Pharmaceuticals, Cosmetics and Related Areas", 2002
R. LAROCK: "Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik and angrenzende Gebiete", 1989, VCH PUBLISHERS
COSTABILE ET AL., MOL PHARM, vol. 12, no. 8, 3 August 2015 (2015-08-03), pages 2604 - 17
BOMMER, R., PHARMACEUTICAL TECHNOLOGY EUROPE, September 1999 (1999-09-01)
LABIRISDOLOVICH, BR J CLIN PHARMACOL, vol. 56, no. 6, December 2003 (2003-12-01), pages 600 - 612
POSTOW, M., J. CLIN. ONCOL., vol. 33, 2015, pages 1
CORMAN ET AL., EUROSURVEILLANCE, vol. 25, 2020, pages 2000045
SENKOWSKI. W., MOL. CANCER THER., vol. J 4, 2015, pages 1504
LIU, CYNTHIA ET AL., RESEARCH AND DEVELOPMENT ON THERAPEUTIC AGENTS AND VACCINES FOR COVID-19 AND RELATED HUMAN CORONAVIRUS DISEASES, 2020
LAI, CHIH-CHENG ET AL.: "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges", INTERNATIONAL J OURNAL OF ANTIMICROBIAL AGENTS, 2020, pages 105924
CHANG, YU-CHUAN ET AL., POTENTIAL THERAPEUTIC AGENTS FOR COVID-19 BASED ON THE ANALYSIS OF PROTEASE AND RNA POLYMERASE DOCKING, 2020
KO WCROLAIN JMLEE NY ET AL.: "Arguments in favor of remdesivir for treating SARS-CoV-2 infections", INT J ANTIMICROB AGENTS, 5 March 2020 (2020-03-05), pages 105933
DHAMA, K. ET AL., CORONAVIRUS DISEASE, 2020
STEBBING, JUSTIN ET AL.: "COVID-19: combining antiviral and anti-inflammatory treatments", THE LANCET INFECTIOUS DISEASES, 2020
YANG, NAIDIHAN-MING SHEN: "Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19", INT J BIOL SCI, vol. 16, no. 10, 2020, pages 1724 - 1731, XP055744881, DOI: 10.7150/ijbs.45498
CASADEVALL, ARTUROLIISE-ANNE PIROFSKI: "The convalescent sera option for containing COVID-19", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 130, no. 4, 2020, XP055724995, DOI: 10.1172/JCI138003
SHANMUGARAJ, BALAMURUGAN ET AL.: "Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19", ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 2020
XU, JIMIN ET AL.: "Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential", ACS INFECTIOUS DISEASES, 2020
GAUTRET ET AL., INT J ANTIMICROB AGENTS, 20 March 2020 (2020-03-20), pages 105949
T. W. GREENERGM. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY AND SONS
HOUSTON, J.B., BIOCHEM PHARMACOL, vol. 47, 1994, pages 1469
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 60, 2016, pages 323
"Antimicrobial Agents and Chemotherapy", vol. 60, 2016, pages: 323
"Remington's Pharmaceutical Sciences", 1980, MACK PUBLISHING CO., pages: 1182
ORG. CHEM. FRONT., vol. 2, 2015, pages 1071 - 1075
J. LABEL COMPD. RADIOPHARM, vol. 53, 2010, pages 662
ORG. BIOMOL. CHEM., vol. 12, 2014, pages 3598
ADV. SYNTH. CATAL., vol. 356, 2014, pages 3551
HOUSTON, J.B. ET AL., DRUG METAB REV, vol. 29, 1997, pages 891
IWATSUBO, T ET AL., PHARMACOL THER, vol. 73, 1997, pages 147
LAVE, T. ET AL., PHARM RES, vol. 14, 1997, pages 152
Attorney, Agent or Firm:
DORIGO, Andrea et al. (US)
Download PDF:
Previous Patent: METHODS FOR ADMINISTERING LUCITANIB AND COMBINATIONS THEREOF
Next Patent: HIGH LEVEL SYNTAX FOR GEOMETRY-BASED POINT CLOUD COMPRESSION
Next Patent: HIGH LEVEL SYNTAX FOR GEOMETRY-BASED POINT CLOUD COMPRESSION