Title:
DEUTERATED OLIGONUCLEOTIDE AND PRODRUG
Document Type and Number:
WIPO Patent Application WO/2019/219070
Kind Code:
A1
Abstract:
The present invention belongs to the field of medicinal chemistry and relates to a deuterated oligonucleotide and a prodrug. In particular, the present invention relates to a compound represented by formula I or a pharmaceutically acceptable salt thereof, a preparation method, a pharmaceutical composition, and a medical use. The medical use comprises a use in treating hepatitis B virus infection, especially a liver disease caused by hepatitis B virus infection.
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Inventors:
ZHANG YINSHENG (CN)
LIU BAOMIN (CN)
HUANG YU (CN)
ZHU YAN (CN)
ZHANG YANG (CN)
TONG SHUNYU (CN)
WANG XIAOJIN (CN)
XU HONGJIANG (CN)
LIU BAOMIN (CN)
HUANG YU (CN)
ZHU YAN (CN)
ZHANG YANG (CN)
TONG SHUNYU (CN)
WANG XIAOJIN (CN)
XU HONGJIANG (CN)
Application Number:
PCT/CN2019/087349
Publication Date:
November 21, 2019
Filing Date:
May 17, 2019
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
A61K31/7072; C07H19/20; A61P31/14
Domestic Patent References:
| WO2007070598A2 | 2007-06-21 | |||
| WO2002092006A2 | 2002-11-21 |
Foreign References:
| CN106699828A | 2017-05-24 | |||
| CN105669751A | 2016-06-15 |
Other References:
LIU JIE: "Deuterated Drugs Progress", PHARMACEUTICAL AND CHEMICAL, vol. 42, no. 4, 30 April 2016 (2016-04-30), pages 199 - 238
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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