Title:
DEUTERATED PHENYLPROPIONIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/005753
Kind Code:
A1
Abstract:
A compound, in which some or all of the hydrogen atoms of the ethylene group constituting propionic acid in 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]phenyl]propionic acid have been substituted with deuterium, or a salt thereof, or an ester thereof, and a prodrug for releasing Am80 as an active medicament after absorption in the body, which comprises the compound or a salt thereof, or an ester thereof as an active ingredient.
Inventors:
MURATAKE HIDEAKI (JP)
SHUDO KOICHI (JP)
AMANO YOHEI (JP)
TODA TAKAHIRO (JP)
SHUDO KOICHI (JP)
AMANO YOHEI (JP)
TODA TAKAHIRO (JP)
Application Number:
PCT/JP2012/067033
Publication Date:
January 10, 2013
Filing Date:
July 04, 2012
Export Citation:
Assignee:
RES FOUND ITSUU LAB (JP)
MURATAKE HIDEAKI (JP)
SHUDO KOICHI (JP)
AMANO YOHEI (JP)
TODA TAKAHIRO (JP)
MURATAKE HIDEAKI (JP)
SHUDO KOICHI (JP)
AMANO YOHEI (JP)
TODA TAKAHIRO (JP)
International Classes:
C07C233/65; A61K31/192
Domestic Patent References:
| WO2009057199A1 | 2009-05-07 |
Foreign References:
| JP2008094727A | 2008-04-24 | |||
| JPS6122047A | 1986-01-30 | |||
| JPS6176440A | 1986-04-18 |
Other References:
SUGITANI M. ET AL.: "Disposition of a New Tamibarotene Prodrug in Mice", BIOL. PHARM. BULL., vol. 32, no. 12, 2009, pages 1997 - 2001, XP055142143
SANDERSON K.: "Big interest in heavy drugs", NATURE, vol. 458, 2009, pages 269, XP009114123
JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 11, 1988, pages 2182
EVANS, R.M., SCIENCE, vol. 240, 1988, pages 889
PETKOVICH, M. ET AL., NATURE, vol. 330, 1987, pages 444 - 450
MANGELSDORF, D. J. ET AL., NATURE, vol. 345, pages 224 - 229
HASHIMOTO, Y., CELL STRUCT. FUNCT., vol. 16, 1991, pages 113 - 123
HASHIMOTO, Y ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 166, 1990, pages 1300 - 1307
"Amnolake Tablets", TOKO PHARMACEUTICAL INDUSTRIAL CO., LTD.
CELL STRUCT. FUNCT., vol. 16, 1991, pages 113 - 123
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 166, 1990, pages 1300 - 1307
SAJIKI ET AL., TETRAHEDRON LETTERS, vol. 46, 2005, pages 6995 - 6998
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN, vol. 65, 2007, pages 1179 - 1189
See also references of EP 2730559A4
SANDERSON K.: "Big interest in heavy drugs", NATURE, vol. 458, 2009, pages 269, XP009114123
JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 11, 1988, pages 2182
EVANS, R.M., SCIENCE, vol. 240, 1988, pages 889
PETKOVICH, M. ET AL., NATURE, vol. 330, 1987, pages 444 - 450
MANGELSDORF, D. J. ET AL., NATURE, vol. 345, pages 224 - 229
HASHIMOTO, Y., CELL STRUCT. FUNCT., vol. 16, 1991, pages 113 - 123
HASHIMOTO, Y ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 166, 1990, pages 1300 - 1307
"Amnolake Tablets", TOKO PHARMACEUTICAL INDUSTRIAL CO., LTD.
CELL STRUCT. FUNCT., vol. 16, 1991, pages 113 - 123
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 166, 1990, pages 1300 - 1307
SAJIKI ET AL., TETRAHEDRON LETTERS, vol. 46, 2005, pages 6995 - 6998
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN, vol. 65, 2007, pages 1179 - 1189
See also references of EP 2730559A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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