Title:
DEUTERATED TETRAHYDROTHIENO[3,4-D]PYRIMIDINEDIONE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/228236
Kind Code:
A1
Abstract:
Provided are a deuterated tetrahydrothieno[3,4-d]pyrimidinedione compound as represented by formula (I) and a pharmaceutical composition containing the compound, or a crystal form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof. The compound can be used for treating and/or preventing gonadotropin-releasing hormone (GnRH)-dependent related diseases, such as hysteromyoma, endometriosis, uterine fibroids, amenorrhea, premenstrual syndrome, etc.
Inventors:
LV BINHUA (CN)
LI CHENGWEI (CN)
YANG JINGENG (CN)
SONG ZENG (CN)
LI CHENGWEI (CN)
YANG JINGENG (CN)
SONG ZENG (CN)
Application Number:
PCT/CN2021/093882
Publication Date:
November 18, 2021
Filing Date:
May 14, 2021
Export Citation:
Assignee:
SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
International Classes:
C07D495/04; A61K31/519; A61P15/00
Foreign References:
| CN101331134A | 2008-12-24 | |||
| CN108129400A | 2018-06-08 |
Other References:
YINSHENG ZHANG: "Development of deuterated drugs: past, present and future", PROGRESS IN PHARMACEUTICAL SCIENCES, CHINA PHARMACEUTICAL UNIVERSITY, CN, vol. 41, no. 12, 31 December 2017 (2017-12-31), CN , pages 902 - 918, XP009521674, ISSN: 1001-5094
HUANG YU, CHEN JINGSHUN, LIU BAOMIN, WANG HUA, ZHANG LU, CHEN ZHENGBANG, ZHANG YINSHENG: "An efficient synthesis of deuterium-labeled degarelix acetate, a third-generation gonadotropin-releasing hormone receptor antagonist", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY & SONS LTD., GB, vol. 61, no. 4, 1 April 2018 (2018-04-01), GB , pages 355 - 361, XP055781965, ISSN: 0362-4803, DOI: 10.1002/jlcr.3567
HUANG YU, CHEN JINGSHUN, LIU BAOMIN, WANG HUA, ZHANG LU, CHEN ZHENGBANG, ZHANG YINSHENG: "An efficient synthesis of deuterium-labeled degarelix acetate, a third-generation gonadotropin-releasing hormone receptor antagonist", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY & SONS LTD., GB, vol. 61, no. 4, 1 April 2018 (2018-04-01), GB , pages 355 - 361, XP055781965, ISSN: 0362-4803, DOI: 10.1002/jlcr.3567
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
Download PDF: