Title:
DEVELOPMENT OF MICROBIAL BIOSENSORS FOR INTESTINAL INFLAMMATION
Document Type and Number:
WIPO Patent Application WO/2018/209318
Kind Code:
A3
Abstract:
Embodiments of the disclosure include systems, methods, and compositions for detection of imminent onset of a symptom of a gut inflammation medical condition. The disclosure also concerns microbial biosensors that detect a marker in the gut that is predictive of onset of at least one symptom of inflammatory bowel disease (IBD), for example, and such a sensor may include a promoter sensitive to the marker that is linked to expression of a detectable readout, such as in the feces of the individual with IBD.
Inventors:
BRITTON ROBERT (US)
GALLEY JEFFREY (US)
GALLEY JEFFREY (US)
Application Number:
PCT/US2018/032457
Publication Date:
March 26, 2020
Filing Date:
May 11, 2018
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE (US)
International Classes:
A61K35/741; C12N15/63; C12N15/70
Domestic Patent References:
| WO2016106343A1 | 2016-06-30 |
Foreign References:
| US20160312313A1 | 2016-10-27 |
Other References:
CHO ET AL.: "Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections", PLOS PATHOG, vol. 11, no. 7, 6 July 2015 (2015-07-06), pages 1 - 23, XP055694303
Attorney, Agent or Firm:
SISTRUNK, Melissa, L. et al. (US)
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