Title:
DEVELOPMENT OF NOVEL FGF21 VARIANT, AND PRODUCTION TECHNIQUE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/260468
Kind Code:
A1
Abstract:
The present invention relates to the development of a novel FGF21 variant and a method for producing or purifying same. The novel FGF21 variant according to an embodiment of the present invention has signal transduction activity that is increased by a factor of about 6 compared to wild-type FGF21, and thus the variant may be evaluated as being a drug candidate having value as a biobetter.
Inventors:
CHA SUN SHIN (KR)
JUNG YE-EUN (KR)
BAE DA-WOON (KR)
JEONG BO-GYEONG (KR)
JUNG YEON JU (KR)
KANG BU-GYEONG (KR)
KIM MYEONG-YEON (KR)
YOUN SO YEON (KR)
LEE JUNG-HYUN (KR)
YIM HYUNG-SOON (KR)
LEE KYEONG WON (KR)
AN YOUNG JUN (KR)
KWON KAE KYOUNG (KR)
KANG SUNG GYUN (KR)
LEE HYUN SOOK (KR)
JUNG YE-EUN (KR)
BAE DA-WOON (KR)
JEONG BO-GYEONG (KR)
JUNG YEON JU (KR)
KANG BU-GYEONG (KR)
KIM MYEONG-YEON (KR)
YOUN SO YEON (KR)
LEE JUNG-HYUN (KR)
YIM HYUNG-SOON (KR)
LEE KYEONG WON (KR)
AN YOUNG JUN (KR)
KWON KAE KYOUNG (KR)
KANG SUNG GYUN (KR)
LEE HYUN SOOK (KR)
Application Number:
PCT/KR2022/008202
Publication Date:
December 15, 2022
Filing Date:
June 10, 2022
Export Citation:
Assignee:
DOORCO KOREA CO LTD (KR)
International Classes:
C07K14/50; A61K38/00; A61P3/00; A61P9/00
Foreign References:
| KR20150006060A | 2015-01-15 | |||
| KR102217254B1 | 2021-02-19 | |||
| KR20180083938A | 2018-07-23 | |||
| KR20170095256A | 2017-08-22 | |||
| KR20220059660A | 2022-05-10 | |||
| KR20210075460A | 2021-06-23 |
Other References:
"Current protocols in protein science", WILEY , US , article JOHN MCCOY, EDWARD LAVALLIE: "Expression and Purification of Thioredoxin Fusion Proteins", pages: 16.8.1 - 16.8.14, XP009151941, DOI: 10.1002/0471142727.mb1608s28
JUNG YE-EUN, LEE KYEONG WON, CHO JAE HYUN, BAE DA-WOON, JEONG BO-GYEONG, JUNG YEON-JU, AN YOUNG JUN, KIM KYUNGCHAN, LEE GA SEUL, K: "Temperature-responsive structural reversibility of FGF21 and structure-based design of its variant with enhanced potency", BIORXIV, 29 November 2021 (2021-11-29), pages 1 - 32, XP093014596, DOI: 10.1101/2021.11.16.468794
JUNG YE-EUN, LEE KYEONG WON, CHO JAE HYUN, BAE DA-WOON, JEONG BO-GYEONG, JUNG YEON-JU, AN YOUNG JUN, KIM KYUNGCHAN, LEE GA SEUL, K: "Temperature-responsive structural reversibility of FGF21 and structure-based design of its variant with enhanced potency", BIORXIV, 29 November 2021 (2021-11-29), pages 1 - 32, XP093014596, DOI: 10.1101/2021.11.16.468794
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
Download PDF: