Title:
DEVELOPMENT OF THERAPY FOR IMPROVING MYOCARDIAL CONTRACTION AND METHOD FOR INHIBITING CARDIOMYOCYTE DEATH
Document Type and Number:
WIPO Patent Application WO/2021/010344
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical for the prevention and/or treatment of nonischemic cardiomyopathy, said pharmaceutical containing dendritic cells obtained via a method including: a step in which mononuclear cells are cultured in the presence of GM-CSF and IL-2; and a step in which the cultured cells are pulsed with α-Galactosylceramide.
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Inventors:
TSUTSUI HIROYUKI (JP)
IDE TOMOMI (JP)
OHTANI KISHO (JP)
MATSUSHIMA SHOJI (JP)
IKEDA MASATAKA (JP)
IDE TOMOMI (JP)
OHTANI KISHO (JP)
MATSUSHIMA SHOJI (JP)
IKEDA MASATAKA (JP)
Application Number:
PCT/JP2020/027115
Publication Date:
January 21, 2021
Filing Date:
July 10, 2020
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61P9/00; A61K31/704; A61K35/15; A61P9/04; A61P9/10; A61P43/00
Domestic Patent References:
| WO2015129791A1 | 2015-09-03 | |||
| WO2015129791A1 | 2015-09-03 | |||
| WO2003016326A1 | 2003-02-27 |
Other References:
TSUTSUI, HIROYUKI: "Role of Natural Killer T Cells in Cardiac Remodeling and Failure and the Development of Novel Therapeutic Strategy", FUKUOKA ACTA MEDICA, vol. 107, no. 10, 25 October 2016 (2016-10-25), JP , pages 177 - 184, XP009533160, ISSN: 0016-254X
NAKAJIMA, H. ET AL.: "Delivery Route in Bone Marrow Cell Transplantation Should be Optimized According to the Etiology of Heart Disease", CIRCULATION J., vol. 72, no. 9, 2008, pages 1528 - 1535, XP055788099, DOI: 10.1253/circj.cj-06-0430
BARRETT-LEE, P.J. ET AL.: "Review; Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk", ANNALS OF ONCOLOGY, vol. 20, no. 5, 2009, pages 816 - 827, XP055788101, DOI: doi.org/10.1093/annonc/mdn728
WANG, L. ET AL.: "Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein", SCIENTIFIC REPORTS, vol. 6, no. 28399, 2016, XP055788114, Retrieved from the Internet
BARRETT P J ET AL., ANN. ONCOL., vol. 20, 2009, pages 816 - 827
FELKER GM ET AL., N. ENG. J. MED., vol. 342, 2000, pages 1077 - 1084
WANG L ET AL., SCI. REP., vol. 6, 21 June 2016 (2016-06-21), pages 28399
A. RIAD ET AL., EUROPEAN JOURNAL OF HEART FAILURE, vol. 10, 2008, pages 233 - 243
SOBIRIN M.A. ET AL., CIRC. RES., vol. 111, 2012, pages 1037 - 1047
VAN KAER L., NAT. REV. IMMUNOL, vol. 5, 2005, pages 31 - 42
ISHIKAWA E ET AL., INT. J. CANCER, vol. 117, 2005, pages 265 - 273
FUJII ET AL., NAT. IMMUNOL., vol. 3, 2002, pages 867
ISHIKAWA A ET AL., CLIN. CANCER RES., vol. 11, 2005, pages 1910 - 1917
GODFREY DI ET AL., NAT. REV. IMMUNOL., vol. 7, 2007, pages 505 - 518
HOMMA T. ET AL., J. MOL. CELL, vol. 62, 2013, pages 179 - 188
ENDRE PAL ET AL., J. IMMUNOL., vol. 166, 2001, pages 662 - 668
SHARIF S ET AL., NAT. MED., vol. 7, 2001, pages 1057 - 1062
MORIMOTO ET AL., CIRCULATION RESEARCH, 2017, pages 185 - 194
NONAKA ET AL., BRITISH JOURNAL OF PHARMACOLOGY, vol. 172, 2015, pages 2369 - 2382
TASHIRO T., BIOSCI. BIOTECHNOL. BIOCHEM., vol. 76, no. 6, 2012, pages 1055 - 67
HEART FAIL, vol. 3, 1987, pages 198 - 209
J. AM. COLL. CARDIOL., vol. 35, 2000, pages 1245 - 5
See also references of EP 3984597A4
NAKAJIMA, H. ET AL.: "Delivery Route in Bone Marrow Cell Transplantation Should be Optimized According to the Etiology of Heart Disease", CIRCULATION J., vol. 72, no. 9, 2008, pages 1528 - 1535, XP055788099, DOI: 10.1253/circj.cj-06-0430
BARRETT-LEE, P.J. ET AL.: "Review; Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk", ANNALS OF ONCOLOGY, vol. 20, no. 5, 2009, pages 816 - 827, XP055788101, DOI: doi.org/10.1093/annonc/mdn728
WANG, L. ET AL.: "Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein", SCIENTIFIC REPORTS, vol. 6, no. 28399, 2016, XP055788114, Retrieved from the Internet
BARRETT P J ET AL., ANN. ONCOL., vol. 20, 2009, pages 816 - 827
FELKER GM ET AL., N. ENG. J. MED., vol. 342, 2000, pages 1077 - 1084
WANG L ET AL., SCI. REP., vol. 6, 21 June 2016 (2016-06-21), pages 28399
A. RIAD ET AL., EUROPEAN JOURNAL OF HEART FAILURE, vol. 10, 2008, pages 233 - 243
SOBIRIN M.A. ET AL., CIRC. RES., vol. 111, 2012, pages 1037 - 1047
VAN KAER L., NAT. REV. IMMUNOL, vol. 5, 2005, pages 31 - 42
ISHIKAWA E ET AL., INT. J. CANCER, vol. 117, 2005, pages 265 - 273
FUJII ET AL., NAT. IMMUNOL., vol. 3, 2002, pages 867
ISHIKAWA A ET AL., CLIN. CANCER RES., vol. 11, 2005, pages 1910 - 1917
GODFREY DI ET AL., NAT. REV. IMMUNOL., vol. 7, 2007, pages 505 - 518
HOMMA T. ET AL., J. MOL. CELL, vol. 62, 2013, pages 179 - 188
ENDRE PAL ET AL., J. IMMUNOL., vol. 166, 2001, pages 662 - 668
SHARIF S ET AL., NAT. MED., vol. 7, 2001, pages 1057 - 1062
MORIMOTO ET AL., CIRCULATION RESEARCH, 2017, pages 185 - 194
NONAKA ET AL., BRITISH JOURNAL OF PHARMACOLOGY, vol. 172, 2015, pages 2369 - 2382
TASHIRO T., BIOSCI. BIOTECHNOL. BIOCHEM., vol. 76, no. 6, 2012, pages 1055 - 67
HEART FAIL, vol. 3, 1987, pages 198 - 209
J. AM. COLL. CARDIOL., vol. 35, 2000, pages 1245 - 5
See also references of EP 3984597A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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