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Title:
DEVELOPMENT OF UNIQUE CAFFEIC ACID PHENETHYL ESTER MOLECULES THAT ARE CANDIDATES FOR BEING CANCER DRUGS AND DETERMINING BIOLOGICAL ACTIVITIES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/076274
Kind Code:
A3
Abstract:
The present invention is related to unique caffeic acid phenethyl ester (CAPE) analogues, methods for preparation of said molecules, and the usage of said unique molecules in the preparation of a pharmaceutical composition that is to be used in treating cancer and/or treating diseases induced by the cancer metabolism.

Inventors:
GUZEL MUSTAFA (TR)
SUCU BILGESU ONUR (TR)
ŞAVLUĞ ÖZGECAN (TR)
KARAKAŞ NIHAL (TR)
KOÇ ELIF BEYZA (TR)
GÜZEL MELIKE AYBALA (TR)
ÖZTÜRK İREM (TR)
TOSYALI İBRAHIM SERKUT (TR)
YILMAZ RABIA (TR)
Application Number:
TR2019/050848
Publication Date:
July 16, 2020
Filing Date:
October 09, 2019
Export Citation:
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Assignee:
ISTANBUL MEDIPOL UNIV (TR)
T C USKUDAR UNIV (TR)
International Classes:
A61P35/00; A61K31/4245; C07C233/00; C07D209/16; C07D209/30; C07D213/75; C07D215/38; C07D233/64; C07D239/42; C07D241/44; C07D249/08; C07D263/32; C07D265/36; C07D271/06; C07D285/08; C07D295/16; C07D307/82; C07D309/14; C07D319/20; C07D333/66; C07D403/12; C07D407/04; C07D407/10
Foreign References:
CN103304467B2015-10-14
Other References:
YAMAZAKI YOSHIMITSU ET AL: "N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 15, 2009, pages 4178 - 4182, XP029120822, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2009.05.115
MISRA KAUSHIK ET AL: "Radical scavenging and antibacterial activity of caffemides against gram positive, gram negative and clinical drug resistance bacteria", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 26, no. 24, 31 October 2016 (2016-10-31), pages 5943 - 5946, XP029824625, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2016.10.089
PUBCHEM: "1-Phenylpropan-2-yl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | C18H18O4 - PubChem", US2006116356 AND US2008076738, 19 August 2012 (2012-08-19), pages 1 - 11, XP055671663, Retrieved from the Internet [retrieved on 20200226]
PUBCHEM: "2-Phenylpropyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | C18H18O4 - PubChem", US2008076738 AND US2006116356, 19 August 2012 (2012-08-19), pages 1 - 11, XP055671671, Retrieved from the Internet [retrieved on 20200226]
MARIA A. PATRAS ET AL: "Profiling and Quantification of Regioisomeric Caffeoyl Glucoses in Berry Fruits", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 66, no. 5, 7 February 2018 (2018-02-07), US, pages 1096 - 1104, XP055671665, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.7b02446
FAN P ET AL: "Chemical constituents of Asplenium ruta-muraria L", NATURAL PRODUCT RESEARCH, TAYLOR & FRANCIS, LONDON, 1 June 2012 (2012-06-01), pages 1413 - 1418, XP055671668, ISSN: 1478-6427, DOI: 10.1080/14786419.2011.599805
Attorney, Agent or Firm:
SIMSEK, Meliha Merve (TR)
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