Title:
DEVICE FOR ANALYZING CELLULAR PRODUCTIVITY, APPARATUS FOR ANALYZING CELLULAR PRODUCTIVITY, METHOD FOR ANALYZING CELLULAR PRODUCTIVITY, AND SYSTEM FOR ANALYZING CELLULAR PRODUCTIVITY
Document Type and Number:
WIPO Patent Application WO/2018/179735
Kind Code:
A1
Abstract:
The present invention provides a device for analyzing cellular productivity, the device having: a flow channel through which flows a sample containing cells; a cell capturing part which captures the cells; a cell product binding part to which cellular products produced by the cells captured by the cell capturing part binds; and a flow channel through which the sample flows, wherein a flow channel through which a reagent flows intersects at the cell product binding part.
Inventors:
BRUN MARCAURELE (JP)
HOSOKAWA HIROYUKI (JP)
KATO YOSHIAKI (JP)
MASUHARA SHIN (JP)
HOSOKAWA HIROYUKI (JP)
KATO YOSHIAKI (JP)
MASUHARA SHIN (JP)
Application Number:
PCT/JP2018/002037
Publication Date:
October 04, 2018
Filing Date:
January 24, 2018
Export Citation:
Assignee:
SONY CORP (JP)
International Classes:
C12M1/34; C12M1/00; C12Q1/04; C12Q1/68; G01N33/53
Domestic Patent References:
| WO2016065242A1 | 2016-04-28 | |||
| WO2017056362A1 | 2017-04-06 | |||
| WO2017057234A1 | 2017-04-06 |
Foreign References:
| JP2009505634A | 2009-02-12 | |||
| JP2008539711A | 2008-11-20 | |||
| JP2004290875A | 2004-10-21 | |||
| JP2015527588A | 2015-09-17 | |||
| JP2012511155A | 2012-05-17 | |||
| JP2004516029A | 2004-06-03 | |||
| JPH0214A | 1990-01-05 |
Other References:
HEATH, J.R. ET AL.: "Single cell analytic tools for drug discovery and develeopment", NATURE REVIEWS. DRUG DISCOVERY , AUTHOR MANUSCRIPT, vol. 15, no. 3, 27 May 2016 (2016-05-27), pages 1 - 28, XP055556579
MA, C. ET AL.: "A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells", NAT. MED., vol. 17, no. 6, 2011, pages 738 - 743, XP055243826, DOI: doi:10.1038/nm.2375
SON, K.J. ET AL.: "Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells", ANALYST, vol. 141, no. 2, 2016, pages 679 - 688, XP055610963
DENG, Y. ET AL.: "An integrated microfluidic chip system for single- cell secretion profiling of rare circulating tumor cells", SCIENTIFIC REPORTS, vol. 4, no. 7499, 2014, pages 1 - 8, XP055423007
ELITAS, M. ET AL.: "A microchip platform for interrogating tumor-macrophage paracrine signaling at the single- cell level", LAB CHIP, vol. 14, no. 18, 2014, pages 3582 - 3588, XP055257109
CHENG, Y.-H. ET AL.: "Scaling and automation of a high-throughput single- cell -derived tumor sphere assay chip", LAB CHIP, vol. 16, no. 19, 2016, pages 3708 - 3717
LINDSTROM, S. ET AL.: "Overview of single- cell analyses:microdevices and applications", LAB CHIP, vol. 10, no. 24, 2010, pages 3363 - 3372, XP055000729, DOI: doi:10.1039/c0lc00150c
MA, C. ET AL.: "A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells", NAT. MED., vol. 17, no. 6, 2011, pages 738 - 743, XP055243826, DOI: doi:10.1038/nm.2375
SON, K.J. ET AL.: "Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells", ANALYST, vol. 141, no. 2, 2016, pages 679 - 688, XP055610963
DENG, Y. ET AL.: "An integrated microfluidic chip system for single- cell secretion profiling of rare circulating tumor cells", SCIENTIFIC REPORTS, vol. 4, no. 7499, 2014, pages 1 - 8, XP055423007
ELITAS, M. ET AL.: "A microchip platform for interrogating tumor-macrophage paracrine signaling at the single- cell level", LAB CHIP, vol. 14, no. 18, 2014, pages 3582 - 3588, XP055257109
CHENG, Y.-H. ET AL.: "Scaling and automation of a high-throughput single- cell -derived tumor sphere assay chip", LAB CHIP, vol. 16, no. 19, 2016, pages 3708 - 3717
LINDSTROM, S. ET AL.: "Overview of single- cell analyses:microdevices and applications", LAB CHIP, vol. 10, no. 24, 2010, pages 3363 - 3372, XP055000729, DOI: doi:10.1039/c0lc00150c
Attorney, Agent or Firm:
WATANABE Kaoru (JP)
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