Title:
DEVICE FOR MEASURING CELL TRACTION FORCE, AND MEASURING METHOD AND PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO2017008699
Kind Code:
A1
Abstract:
Disclosed are a device for measuring the cell traction force, and a measuring method and a preparation method, wherein the measuring device comprises: a substrate layer (3); a nanowire layer (1) located on the substrate layer (3), comprising nanowire arrays, wherein nanowires (11) can be bent under the effect of an external force; and a light-emitting layer (2), comprising luminous points (21) arranged on the end of each nanowire (11), and supporting the bending of the nanowire (11) of a supporting cell (4) to be tested, and driving the movement of the luminous point (21) on the end of nanowire (11) to produce the shifting displacement representing the cell (4) traction force after the cell (4) to be tested is arranged on the light-emitting layer (2). The device for measuring the cell traction force acquires the shifting displacement representing the cell (4) traction force in real time according to the movement situation of the luminous point (21) of the light-emitting layer (2), and has a high accuracy.
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Inventors:
LI ZHOU (CN)
JIN YIMING (CN)
ZHANG YALAN (CN)
ZHENG QIANG (CN)
OUYANG HAN (CN)
WANG ZHONGLIN (CN)
JIN YIMING (CN)
ZHANG YALAN (CN)
ZHENG QIANG (CN)
OUYANG HAN (CN)
WANG ZHONGLIN (CN)
Application Number:
PCT/CN2016/089401
Publication Date:
January 19, 2017
Filing Date:
July 08, 2016
Export Citation:
Assignee:
BEIJING INST NANOENERGY & NANOSYSTEMS (CN)
International Classes:
G01N21/64; B82Y40/00
Domestic Patent References:
| WO2008066965A2 | 2008-06-05 | |||
| WO2012139715A1 | 2012-10-18 | |||
| WO2013074972A1 | 2013-05-23 |
Foreign References:
| CN103325663A | 2013-09-25 | |||
| CN104359876A | 2015-02-18 | |||
| CN103168360A | 2013-06-19 | |||
| CN103018429A | 2013-04-03 | |||
| US20110309265A1 | 2011-12-22 | |||
| US20090242416A1 | 2009-10-01 |
Other References:
ZHOU, ZHIGUO ET AL.: "Microcantilever Matrix Sensor Fabrication for Cell Traction Force Measurement", CHINESE JUOURNAL OF SENSORS AND ACTUATORS, vol. 22, no. 5, 31 May 2009 (2009-05-31), pages 627 - 631
LI, SHANSHAN ET AL.: "High-resolution cellular traction force recovery in two-dimensional Fourier domain", JOURNAL OF MEDICAL BIOMECHANICS, vol. 26, no. 3, 30 June 2011 (2011-06-30), pages 225 - 231
LI, SHANSHAN ET AL.: "High-resolution cellular traction force recovery in two-dimensional Fourier domain", JOURNAL OF MEDICAL BIOMECHANICS, vol. 26, no. 3, 30 June 2011 (2011-06-30), pages 225 - 231
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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