Title:
DEVICE AND METHOD FOR ANALYZING ION CHANNELS IN MEMBRANES
Document Type and Number:
WIPO Patent Application WO2002066596
Kind Code:
A3
Abstract:
The invention relates to devices and methods for analyzing ion channels in membranes. The invention is characterized by a biochip with a substrate wherein openings are provided in the form of an MxN matrix for receiving a cell membrane comprising at least one ion channel (l) or an artificial lipid membrane (Me), whereby M >/= 1 and >/= 1.
Inventors:
FERTIG NIELS (DE)
BEHRENDS JAN (DE)
BLICK ROBERT (DE)
BEHRENDS JAN (DE)
BLICK ROBERT (DE)
Application Number:
PCT/EP2002/000078
Publication Date:
March 27, 2003
Filing Date:
January 07, 2002
Export Citation:
Assignee:
FERTIG NIELS (DE)
BEHRENDS JAN (DE)
BLICK ROBERT (DE)
BEHRENDS JAN (DE)
BLICK ROBERT (DE)
International Classes:
C12M1/34; G01N33/487; (IPC1-7): C12M1/34
Domestic Patent References:
| WO1999031503A1 | 1999-06-24 | |||
| WO1994025862A1 | 1994-11-10 | |||
| WO2000025121A1 | 2000-05-04 | |||
| WO1999066329A1 | 1999-12-23 | |||
| WO1995016206A1 | 1995-06-15 |
Foreign References:
| DE19827957A1 | 1999-12-09 | |||
| DE19936302A1 | 2001-02-15 |
Other References:
FERTIG N ET AL: "Stable integration of isolated cell membrane patches in a nanomachined aperture", APPLIED PHYSICS LETTERS, vol. 77, no. 8, 21 August 2000 (2000-08-21), pages 1218 - 1220, XP000942202, ISSN: 0003-6951
FERTIG N ET AL: "Nanostructured suspended aperture for patch clamp recording and scanning probe applications on native cell membranes.", EUROPEAN BIOPHYSICS JOURNAL, vol. 29, no. 4-5, 2000, 3rd European Biophysics Congress;Munchen, Germany; September 09-13, 2000, pages 376, XP000985217, ISSN: 0175-7571
KATHRYN G KLEMIC ET AL: "QUARZ "MICROCHIP" PARTITIONS FOR IMPROVED PLANAR LIPID BILAYER RECORDING OF SINGLE CHANNEL CURRENTS", BIOPHYSICAL JOURNAL, vol. 78, no. 1, Part 2, January 2000 (2000-01-01), 44th Annual Meeting of the Biophysical Society.;New Orleans, Louisiana, USA; February 12-16, 2000, pages 266A, XP002164207, ISSN: 0006-3495
SCHMIDT C ET AL: "A CHIP-BASED BIOSENSOR FOR THE FUNCTIONAL ANALYSIS OF SINGLE ION CHANNELS", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, VERLAG CHEMIE. WEINHEIM, DE, vol. 39, no. 3137, 2000, pages 3137 - 3140, XP001002622, ISSN: 0570-0833
SEAMAN R L ET AL: "OPEN-ENDED COAXIAL EXPOSURE DEVICE FOR APPLYING RF/MICROWAVE FIELDSTO VERY SMALL BIOLOGICAL PREPARATIONS", IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, IEEE INC. NEW YORK, US, vol. 37, no. 1, 1989, pages 102 - 111, XP000097550, ISSN: 0018-9480
FORSTER J D ET AL: "An exposure system for variable electromagnetic-field orientation electrophysiological studies", IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, AUG. 1985, USA, vol. MTT-33, no. 8, pages 674 - 680, XP001080147, ISSN: 0018-9480
ALEKSEEV S I ET AL: "Effects of millimeter waves on ionic currents of Lymnaea neurons.", BIOELECTROMAGNETICS. UNITED STATES 1999, vol. 20, no. 1, 1999, pages 24 - 33, XP001080659, ISSN: 0197-8462
WACHTEL H ET AL: "Effects of low-intensity microwaves on isolated neurons.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. UNITED STATES 28 FEB 1975, vol. 247, 28 February 1975 (1975-02-28), pages 46 - 62, XP001080785, ISSN: 0077-8923
FERTIG N ET AL: "Nanostructured suspended aperture for patch clamp recording and scanning probe applications on native cell membranes.", EUROPEAN BIOPHYSICS JOURNAL, vol. 29, no. 4-5, 2000, 3rd European Biophysics Congress;Munchen, Germany; September 09-13, 2000, pages 376, XP000985217, ISSN: 0175-7571
KATHRYN G KLEMIC ET AL: "QUARZ "MICROCHIP" PARTITIONS FOR IMPROVED PLANAR LIPID BILAYER RECORDING OF SINGLE CHANNEL CURRENTS", BIOPHYSICAL JOURNAL, vol. 78, no. 1, Part 2, January 2000 (2000-01-01), 44th Annual Meeting of the Biophysical Society.;New Orleans, Louisiana, USA; February 12-16, 2000, pages 266A, XP002164207, ISSN: 0006-3495
SCHMIDT C ET AL: "A CHIP-BASED BIOSENSOR FOR THE FUNCTIONAL ANALYSIS OF SINGLE ION CHANNELS", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, VERLAG CHEMIE. WEINHEIM, DE, vol. 39, no. 3137, 2000, pages 3137 - 3140, XP001002622, ISSN: 0570-0833
SEAMAN R L ET AL: "OPEN-ENDED COAXIAL EXPOSURE DEVICE FOR APPLYING RF/MICROWAVE FIELDSTO VERY SMALL BIOLOGICAL PREPARATIONS", IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, IEEE INC. NEW YORK, US, vol. 37, no. 1, 1989, pages 102 - 111, XP000097550, ISSN: 0018-9480
FORSTER J D ET AL: "An exposure system for variable electromagnetic-field orientation electrophysiological studies", IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, AUG. 1985, USA, vol. MTT-33, no. 8, pages 674 - 680, XP001080147, ISSN: 0018-9480
ALEKSEEV S I ET AL: "Effects of millimeter waves on ionic currents of Lymnaea neurons.", BIOELECTROMAGNETICS. UNITED STATES 1999, vol. 20, no. 1, 1999, pages 24 - 33, XP001080659, ISSN: 0197-8462
WACHTEL H ET AL: "Effects of low-intensity microwaves on isolated neurons.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. UNITED STATES 28 FEB 1975, vol. 247, 28 February 1975 (1975-02-28), pages 46 - 62, XP001080785, ISSN: 0077-8923
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