Title:
DEVICE AND METHOD FOR ITERATIVE PHASE RECOVERY BASED ON PIXEL SUPER-RESOLVED ON-CHIP HOLOGRAPHY
Document Type and Number:
WIPO Patent Application WO/2016/019324
Kind Code:
A3
Abstract:
A method for lens-free imaging of a sample or objects within the sample uses multi-height iterative phase retrieval and rotational field transformations to perform wide FOV imaging of pathology samples with clinically comparable image quality to a benchtop lens-based microscope. The solution of the transport-of-intensity (TIE) equation is used as an initial guess in the phase recovery process to speed the image recovery process. The holographically reconstructed image can be digitally focused at any depth within the object FOV (after image capture) without the need for any focus adjustment, and is also digitally corrected for artifacts arising from uncontrolled tilting and height variations between the sample and sensor planes. In an alternative embodiment, a synthetic aperture approach is used with multi-angle iterative phase retrieval to perform wide FOV imaging of pathology samples and increase the effective numerical aperture of the image.
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Inventors:
OZCAN AYDOGAN (US)
GREENBAUM ALON (US)
ZHANG YIBO (US)
FEIZI ALBORZ (US)
LUO WEI (US)
GREENBAUM ALON (US)
ZHANG YIBO (US)
FEIZI ALBORZ (US)
LUO WEI (US)
Application Number:
PCT/US2015/043266
Publication Date:
April 07, 2016
Filing Date:
July 31, 2015
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
G03H1/00; G03H1/04
Domestic Patent References:
| WO2013070287A1 | 2013-05-16 |
Foreign References:
| US20030202634A1 | 2003-10-30 | |||
| US20100135573A1 | 2010-06-03 | |||
| US20130280752A1 | 2013-10-24 |
Other References:
TINGWEI SU ET AL.: "Multi-angle lensless digital holography for depth resolved imaging on a chip", OPT EXPRESS, vol. 18, no. 9, 26 April 2010 (2010-04-26), pages 9690 - 9711, XP009148104, DOI: doi:10.1364/OE.18.009690
Attorney, Agent or Firm:
DAVIDSON, Michael S. (LLP2040 Main Street, Suite 71, Irvine California, US)
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