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Title:
DEVICE THAT WILL USE A COMBINATION OF TECHNOLOGIES THAT WILL DETECT MOLECULAR SIGNATURES/MOLECULAR FINGERPRINTS OF COVID, ALL VIRUSES, ALL STRAINS OF VIRUS, MICROORGANISMS, PATHOGENS, DISEASE, DISORDERS, AND CANCERS BY TYPE
Document Type and Number:
WIPO Patent Application WO/2022/240383
Kind Code:
A1
Abstract:
This device will use a combination or existing "on the shelf" technologies for specific use of detecting molecular signatures/molecular fingerprints of COVID, Virus, and all strains of the virus, microorganisms, pathogens, disease, disorders, and cancer by type by sampling the specific odor with an electronic nose, match the molecular signature/molecular fingerprints with digitized odors in a database, and produce alarms audible, audio, and communication alarms with other data regarding a positive match in the database of digitized unique molecular signatures/molecular fingerprints in the database.

Inventors:
COSENTINO FILADELFO J (US)
Application Number:
PCT/US2021/010024
Publication Date:
November 17, 2022
Filing Date:
May 13, 2021
Export Citation:
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Assignee:
COSENTINO FILADELFO J (US)
International Classes:
G01N33/569; G01N33/574
Domestic Patent References:
WO2019173332A12019-09-12
Foreign References:
US20210085814A12021-03-25
Other References:
ANONYMOUS: "NASA's E-Nose Device Advanced to "Sniff" COVID-19 from Human Breath ", NASA, 7 April 2021 (2021-04-07), XP093008153, Retrieved from the Internet [retrieved on 20221214]
Download PDF:
Claims:
11

The invention claimed is:

1. This device will detect molecular signatures and unique molecular fingerprints of COVID'19, all viruses and sub-strains, other pathogens, disease, human functional disorders, cancers by type and substance's fingerprints with the integration of wireless device technology, Electronic Nose technology, and UVC technology,

2. This device embodies a set of five subsystems: Subsystem embodies th CPU that can be any device or custom CPU to include the operating system, cell phone, wireless device, or land line device functions, alarms, communications operate the database, and interface the electronic nose and sanitization circuit.

3. This device can be permanent, portable, or handheld, and configured in numerous configured configurations with proximate or remote operations and functions and functionality.

4. The sanitization circuit is for specific use of sanitizing and/or deactivation viruses bacteria, and pathogens for this specific use of this device, or any other uses utilizing UVC (290 nm - 100 nmj is proprietary.

5. The use of the Electronic Nose for use of this application of detecting molecular signatures/molecular fingerprints of COV1D, all viruses, one, all or some viruses, microorganisms, pathogens, disease, bodily functional disorders, and cancer by types are proprietary for this application or related applications.

6. The functions, application, and features embodied in this document herein this document are proprietary to this design and patent.

7. The use of the electronic nose for the use embodied in this document are proprietary to for the use embodied in this application.

The molecular signature and/or molecular fingerprint database match is for this use or any other use is proprietary for this application and/or all other other applications.

9. The alarm system embodied in this document is proprietary for this application and/or all other applications.

10. The use of the "on the shelf hardware," as well as any/all other custom or "on the shelf" hardware and software for this or any other use is proprietary.

11. The use of odor embodied within this document for diagnostics purposes is proprietary.

Description:
1

DEVICE THAT WILL USE A COMBINATION OF TECHNOLOGIES THAT WILL DETECT MOLECULAR SIGNATURES/MOLECULAR FINGERPRINTS OF COVID, ALL VIRUSES, ALL STRAINS OF VIRUS, MICROORGANISMS, PATHOGENS, DISEASE,

DISORDERS, AND CANCERS BY TYPE

FIELD

This device is the combination of diverse technologies with "on the shelf hardware, technology, and equipment" for specific use to to detect molecular signatures and unique fingerprints of COVID-19, other pathogens, human functional disorders, and substance's fingerprints as discussed further, stated, and defined.

BACKGROUND

Every pathogen, disease, disorder, microorganism, substance, and cancer has a unique molecular signature, herein will be referred to as odors, that is given and/or sloughed by unique odors of which some are detectable by the human nose, some detected by other species with higher olfactory organs, such as a dog or pig. However, and "electronic nose" can detect disorders and pathogens that humans and dogs cannot detect, and is typically 100% accurate. The electronic nose has a theoretical potential f detecting every substance, and pathogen on Earth, and space itself. The unique orders of of each molecular signature will be referred to as "fingerprints" because even the slightest ad simplest molecular change will change the fingerprint of what is being sniffed and sampled. This device uses existing on the shelf hardware for the specific use of sniffing and identifying all pathogen, disease, disorder, microorganism and cancer and all of the variants by subtypes and strains hereafter referred to as molecular signatures. These molecular signatures will be digitized and loaded into the database software. As the sampled air passes through the electronic nose, there will be instant lookup on the database. An alert will be given if the fingerprint on the database is detected. This device will fill the immediate need for instant and accurate COVID testing in lines, business offices, public transportation, restaurants, public recreation, military, and all businesses, as it will provide instant and accurate identification of C0VID_29 or any fingerprint loaded into the database. Furthermore, the database is virtually unlimited because detecting a specific fingerprint is simple as opposed to all of the fingerprint, artificial intelligence and facial recognition systems. Additionally, the fingerprints of all illegal drugs, pathogens, and illegal trafficking can be detected without Search & Seizure violations. Since this device is noninvasive, there will not be any privacy and human rights violation, as it is sampling air and ambient air to detect the presence of fingerprints in the database. The evolution of this product is to simple identify the fingerprints of what is to be detected, then adding it to the database. The electronic nose is already proven technology. 2

SUMMARY

The use of this combination of existing proven technology in this combination for specific application is unique, novel, an improvement, not obvious, not statuary, improvement in the application for this use as previously discussed in the Summary by using the technology in combination to detect COVID-19 and other molecular fingerprints. The combination of the technologies are useful in many areas of public health, medicine, diagnostics, national security, Customs & Immigration without jeopardizing privacy and personal rights, and has an immediate need for public health and containment of infected and contagious people and animals because of the noninvasive nature of this device. This device can be made within combination of existing hardware, or can be reduced it in size by making the device into one package.

The embodiment can be individual existing hardware current available, it can be cluttered together into a self contained "box" using a cell phone display for visual display, or the technologies can be combined and contained into one new custom made single device with/without a PDS (Power Distribution System) as a portable molecular fingerprint detector.

An example of the functionality is that the device will be able to identify and detect each passenger boarding an airplane to ensure that there are no contagious fingerprints of the passengers being boarded. Another example is a physician giving early diagnosis of a disease before the patient has symptoms. Th diagnosis will be more accurate the current day practicing best guess based on observable symptoms. A portable units will allow businesses to have safe workplace, and business owners can better ensure that the establishment can provide a safe customer experience.

This portable device does not require specialized licensing and training, as the deice will be "smart" and always incorporate the latest technological advancement and miniaturization since its components are always advancing with product evolution. Since this device is noninvasive and has known proven technology, regulation should be unnecessary.

BRIEF DESCRIPTION OF THE DRAWINGS

In the following detailed description, the technology is discussed in detail in my previous publishing "Wireless Personal Communications Services" published by McGraw-Hill Publishing Company that established the platform for and technology for accompanying applications of of wireless devices and digitization, as this device is one of the applications predicted with the cell phones and it evolution to new 3 generation functions, features, and the network and technology that serves personal communications Systems.

Again this patent is for combining the diverse technologies for innovative novel application and usage as a single device, or combination of "on the shelf" existing hardware equipment. The drawings will show a functional diagram of each of the functions of the system and subsystems comprising the device, herein called the "the device."

The device shall use currently "on the shelf" software to perform the specific tasks of matching a database lookup of a specific fingerprint already loaded in the database. There will be an audible alert if there is a matched molecular fingerprint. The device shall issue alarms and communications over current an future communications, such as, WiFi, Bluetooth, LAN/WAN, 5G, and beyond 5G future evolution that will be to use by any cellphone with any adjunct electronic nose and a proprietary software application linked to the database "on the shelf" software database. There will be software for the working application and "on the shelf'interface to the electronic nose.

The device shall have five distinct functional sub systems comprising the entire system of this device. See Drawing 1 of 4 to view the Functional Hardware Design Architecture. There are 5 distinct subsystems comprising the entire device system system. The five subsystems are Subsystem 1, which could be any Apple, or Android CPU, cellphone, or PDA as the CPU (computer processing unit) and database. And it will encompass the application and interface software that will connect to the electronic nose in Subsystem C shown on Drawing page 4 of 4 titled Functional Drawing; Subsystem C, Electronic Nose. Subsystem A will also encompass all of the visual, audible, alarm, and communications software and derivers.

Subsystem B of the device i the Sanitation Circuit. It will be comprised of an "on the shelf" UVC light source (ultraviolet C radiation with wavelength between 200 and 290 nm: all of this type of radiation is filtered out by the ozone layer so that none reaches the Earth's surface. Ultraviolet C is germicidal and is also used in ultraviolet phototherapy.) Subsystem B will also house a standard "on the shelf" computer fan for air intake through the Electronic Nose, into the UVC radiation before being exhausted via the fan outlet. The functions of the fan are to provide air and odor intake into the Electronic Nose for detecting the identified molecular fingerprints to flow past a UVC for sanitation return to the ambient air. The purpose of the UVC is twofold: 1) Ensure there is no residual molecular fingerprints return to the ambient to eliminate false positives, and secondly not to return contagious air into into the ambient air. 2) The purpose of the fan is dual fold: a) Provide intake air and sampled molecular signature within the ambient air, and the odors within the odors of the breath and body of an individual, through the system and b) for exhaust heat from the electronic nose and UVC. 4

Subsystem C is any electronic nose with proven accurate information, and interface software that will be encompassed within the CPU or cellphone for processing. The electronic Nose will seek molecular fingerprints of the airflow. When the Electronic Nose identifies a matched molecular fingerprint within the database, the CPU will send either a “green alert" indicating that no matched fingerprint is present in the sampled airflow. If a molecular fingerprint is detected, the CPU will send a visual "red Alert," an audio alert, and send notifications over any or all preprogrammed communications ports to notify the proper responsible people at local and remote locations to take appropriate action. As the airflow no longer detect molecular fingerprints, the device will return to the safe "green" state. The evolution of this alarm will include he amount of the molecular fingerprints to determine the severity and quantity compared to normal ranges. The Electronic Nose have been proven up to 100% accuracy upon the first sample.

Subsystem D, Intake chamber is a simple fixed or flexible tube or hose that will extent from the Electronic Nose to the person air and odor samples from a person or group of people passing the detector. Theoretically, the device could process one individual per second.

Subsystem E, Power supply embodies a) any 18 VDC power supply to the CPU, typically any cellphone power cord with with er mini USB connection or Apple connector foe the cellphone being used; and b) any battery backup or cellphone battery power supply for portability of the device.

DETAILED DESCRIPTION DESCRIPTION

In the following detailed description, the device embodies the combination of three major existing and proven technologies for a specific and unique use and application that is unique, novel, not obvious, not statuary, improvement in the application for this use to detect molecular signatures and unique molecular fingerprints of COVID-19, other pathogens, human functional disorders, and substance's fingerprints loaded into a database of identified and defined odors that will be either analog or digital added identifiable odors into the database. It should be noted that although the mobile phone is described the teachings of this application it can be also can be used in any other electronic device such as other electronic portable devices, such as laptops, PDAs, mobile communications terminals, media players, navigation devices, cameras, electronic books and notepads and other electronic devices offering access of information and communications. The use of a CPU is ubiquitous throughout the electronic industry. The CPU of the mobile phone will be used at the core software embodying the software application, interface 6.drivers of the electronic, and processing the lookup and matching analog and/or 5 digital molecular fingerprints. The database of identified and defined odors will be input and stored in the database memory in the mobile device and/or device memory and managed by readily available or custom database application.

The Electronic Nose is also ubiquitous in many fields of research, and "sniffing" use, and its software drivers are readily available. Although the Electronic Nose is used for detecting odors, it has never been used for the use of detecting pathogenic odors in a permeant unit or hand held portable unit to detect molecular signatures and unique molecular fingerprints of COVlD-19, other pathogens, human functional disorders, and substance's fingerprints described in this document.

The use of the UVC is well known to be germicidal, but limited primarily to photo therapy and experimental use.

Since the existing technologies are proven and ubiquitous, they will not be described in detail, but only their functionality will be referred.

Figure 1 is the functional hardware diagram of a mobile terminal 101 connected to the electronic nose 105 that will identify the fingerprints of an odor and match it to the defined odors in the database, and will give an alert that is safe with a green visual indication on the mobile device for an individual to pass, or give an red alert with the detected odor fingerprint in the sampled intake airflow through the Intake Camber Sniffer 106. This schematic shows the airflow through the Electronic Nose, passing through the germicidal UVC 104 and sanitized exhaust of both the sampled air and heat from the electronic Nose and UVC. Any mobile device can be used as the CPU, application driver, interface drivers, and database storage. This functional drawing also shows the battery 102 for portable usage, and/or reserve power. The External 18 VDC input cord 103, is a standard mini USB power cord to supply power to the mobile device /CPU 101, UVC 104, and electronic nose 105.

It must be understood that each odor must be obtained and identified by Gas Chromatography before entering into the database embodied within the mobile device/CPU 101.

Figure 2 is a functional Software Architecture Schematic of the Display and Communication Subsystem A. When the electronic nose detected a molecular fingerprint previously input into the database, the CPU signal will flow per Figure 2 as follows. If there are no detected molecular fingerprints are detected, the signs will go to No Detect 209, and keep the Green/ Pass 209 and illuminate the Green/ Pass 210 visual display.

A detected fingerprint from the molecular fingerprint Detect 200 will send the signal to the CPU 201, which is Subsystem B. If there is a matched detected 202, there will be a Red Alert. The Red Alert will activate an Audible Alert 203 and notify 6

203 the response guardian and all authorities having jurisdiction (AHJ) via WiFi 204, Cellular and GPS 205. The Audible Detect 203 will also will initiate a Cellular Call 209 for immediate coordination of all AHJs for safety remediation, and Cellular talk channel to other mobile devices and/or landline calls. Detect 202 will also send reports to any PC, mobile device, or printer the incident, GPS coordinates, and physical location of the detection via Bluetooth 208 within range.

In addition, Fingerprint Detect 202 will Activate a Visual Red Alert 206 to Red Display on the mobile device/CPU screen. The Red Display 211 will advise the safety guardian and AHJs to stop 212 an an individual, take action 213 action per predetermined procedures, procedures, and simultaneous display the location 214 per GPS coordinates.

The molecular Finger Detect 200 will also display the Quantity of Identified fingerprint 215 per database identified ranges, for example first strain COVID-19 acceptable range of finger print will indicate if the pathogen is in its infancy stage, peak stage, or near the end stage.

Figure 3 is a Software Architecture of the Sanitation Circuit, Subsystem B. This subsystem contains redundant UVC radiation bulbs that will kill or deactivate identified fingerprints return into the ambient air for two purposes. 1) the eliminate the possibility of returning contaminated air containing the identified fingerprint or pathogen into the ambient air that could make false positive alerts, and, 2) if the pathogen is a contagion, it will reduce the risk of spreading the sniffed air which may be contagious or dangerous to others. The UVB subsystem will contain redundant UVB radiation bulbs should one have a fault, In addition, there could be redundant fans to 1) bring intake air through the system, and 2) exhaust sanitized return air and heat from the electronic nose 105 and UVC 104. Note: According to multiple sources (NASA, FDA, and others) the wavelengths of the UVA, UVB and UVC regions are as follows:

UVA 400 nm - 320 nm

UVB 320 nm - 290 nm

UVC 290 nm - 100 nm

Sample air will be from the Intake Chamber Sniffer 301, into the electronic nose 302. The electronic nose will be managed by the CPU/Cellphone or PDA 303, through the UVC Sanitizing Circuit 304, and out the Sanitation Exhaust 305 into the ambient air.

Figure 4 is a Functional Drawing of Subsystems B, C and D.

Subsystem B is the Exhaust System 410 within the Sanitizing Circuit 411. It is contains redundant fans to provide intake ambient air 401 through the Sniffer Intake Chamber 402 within the Sanitizing Subsystem B 412. The airflow passes 7 to the Subsystem C 413 Electronic Nose 403, which identifies the molecular fingerprint, and sends the fingerprint to be processed by the CPU/Mobile device. The airflow passes from the Electronic Nose to the Sanitizing Circuit UVC 409 which will kill and or deactivate the odor being sniffed, and on through the Exhaust System 410 to return to the ambient air.

The Electronic Nose 403 will send the information to Subsystem A CPU/mobile device 414. The information from the Electronic Nose 403 will be processed by the CPU 404 embodied within Subsystem A, The CPU 404. Function goes from the CPU 404, to the Database 405 with preloaded and defined odor molecular fingerprints that are obtain from gas chromatography. If there is no matched molecular fingerprint, the CPU 404 will send a signal for the Green/Pass 407 light to remain in the on visual display the green light on the mobile unit visual display. However, if a finger print is detected by matched database lookup, the CPU 404 will deactivate the Green/Pass visual display 407, and activate the Red Alert 406 on the visual display and alerting system on Subsystem A for the Display Communication and Alerting Process on Figure 2 Subsystem, CPU 201.

The invention claimed is:

1. This device will detect molecular signatures and unique molecular fingerprints of COVID-19, all viruses and sub-strains, other pathogens, disease, human functional disorders, cancers by type and substance's fingerprints with the integration of wireless device technology, Electronic Nose technology, and UVC technology,

2. This device embodies a set of five subsystems: Subsystem embodies th CPU that can be any device or custom CPU to include the operating system, cell phone, wireless device, or land line device functions, alarms, communications operate the database, and interface the electronic nose and sanitization circuit,

3. This device can be permanent, portable, or handheld, and configured in numerous configured configurations with proximate or remote operations and functions and functionality.

4. The sanitization circuit is for specific use of sanitizing and/or deactivation viruses bacteria, and pathogens for this specific use of this device, or any other uses utilizing UVC (290 nm - 100 nm) is proprietary.

5. The use of the Electronic Nose for use of this application of detecting molecular signatures/molecular fingerprints of COVID, all viruses, one, all or some viruses, microorganisms, pathogens, disease, bodily functional disorders, and cancer by types are proprietary for this application or related applications.

6. The functions, application, and features embodied in this document herein this document are proprietary to this design and patent.

7. The use of the electronic nose for the use embodied in this document are proprietary to for the use embodied in this application. 8

The molecular signature and/or molecular fingerprint database match is for this use or any other use is proprietary for this application and/or all other other applications.

9. The alarm system embodied in this document is proprietary for this application and/or all other applications.

10. The use of the "on the shelf hardware," as well as any /all other custom or "on the shelf" hardware and software for this or any other use is proprietary.

11. The use of odor embodied within this document for diagnostics purposes is proprietary.

9

Additional Background of the Invention

The inventor was born with Primary Immune Deficiency with the ability to smell different disease, microorganisms, pathogens, and viruses. Being in the electronics industry for 40 years and evolution of electronics and high tech, the inventor has assembled a variety if technologies that will detect COVID and variant strains, other microorganisms, pathogens, and diseases, including cancers.

The Emirati government has trained dogs to sniff people with the COVID virus, and for use entering airplanes before flight. Therefore, if I can smell certain pathogens, and dogs can be trained to detect pathogens, then an electronic device can also detect the pathogens more accurately and faster than mammals.

There are supporting documents of DoD developing an electronic people sensing device in the Vietnam War to detect the presence of humans in caves, manholes, and in the jungle. It was developed by General Electric and was thus awarded the patents which have long expired, and entitled as "The Forgotten Weapon."

This new device is a new specific application that is new and novel using newer technology many diagnostic applications using smells. Every smell has a unique fingerprint or molecular scent. This device will use an electronic nose to collect the 20. emitted scent, match to a database of programmed scents, and identify whether the smell of a person has a pathogen, identify which pathogen, measure the amount of the pathogen to determine stage, and send immediate alerts and communicate to other identified location to take appropriate and immediate action.

This device is very much like the "Tricorder" detection device on Star Trek where the spaceship physician can give immediate diagnosis of any ailment. Specifically, this device will use smell to detect COVID, any variant, other viruses, pathogens, diseases, and even cancers theoretically with 100% accuracy at 100% of the time.

Electronic COVID, Virus, Microorganism, Pathogen, Disease, Detector

This device is a combination of technologies for new and novel utility device that will use odor unique molecular signature/fingerprint to detect and measure COVID, any individual strain, virus, microorganism, pathogen, disease, or cancer. This device has a theoretical 100% accuracy at 100% of the time.

This device will have an intake air sample of breath or natural body odor to detect molecular signature/fingerprint. The sample will use an "electronic nose" to detect 10 the specific molecular signature against a database. Upon a positive signature match with the database, the CPU device will send a visual and audible alert, as well as communications to designated stations or immediate action and reporting to authorities having jurisdiction.

This device will be able to detect other non-invasive molecular signatures of other odors, such as decomposing bodies, and diagnosis of several diseases and conditions that are listed in the database.

There are five subsystems in this hand held or mounted device:

Subsystem A -- a preprogrammed wireless phone or other CPU as the central processing unit to match molecular signature within the intake air. The CPU will match the molecular signature with the database. If there is a match, the device will send a pass/go alert, activate designated communications via Bluetooth, cellular, WiFi, or other transmission technologies. The CPU will also record quantity readings to determine viral shed, age, and stage of the virus or pathogen to determine stage of the pathogen.

Subsystem B -- is a sanitation circuit consisting of either UVB high frequency or ozone to sanitize the out flow air to prevent false positives reading from previous

22. samples or from ambient air. The UVC will sanitize and/or deactivate all of the outflow air.

Subsystem C — is an electronic nose that will sample intake air samples. The “electronic nose" will send detected molecular signatures to match against the programmed database. This requires an application to interface the CPU/cellphone device, and have instant look in the database resident in the CPU/cellphone device.

Subsystem D — is a flexible or rigid tube that intakes the odorous air from either breath and/or body odors. It is a passive and noninvasive device.

Subsystem E — is external power supply, battery, redundant battery, and communications ports. The communication and external alarms can be any wireless transmission, Ethernet, alarm wiring, infrared, or microwave transmission technology. The device can be portable or connected to fixed power.