Title:
DEXTRO BORNEOL FERULATE CRYSTAL FORM, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREFOF
Document Type and Number:
WIPO Patent Application WO/2016/180205
Kind Code:
A1
Abstract:
Disclosed are a novel crystal form of dextro borneol ferulate, a preparation method therefor, a pharmaceutical composition comprising same and application of the novel crystal form. A dextro borneol ferulate crystal form provided in the present invention comprises characteristic X-ray powder diffraction peaks in a position or positions where a 2theta angle is 10.8 degrees ± 0.2 degree, 12.4 degrees ± 0.2 degree, 14.0 degrees ± 0.2 degree, 14.2 degrees ± 0.2 degree, 14.6 degrees ± 0.2 degree, 16.2 degrees ± 0.2 degree, 16.6 degrees ± 0.2 degree, 17.7 degrees ± 0.2 degree, 18.6 degrees ± 0.2 degree, 20.1 degrees ± 0.2 degree, 21.4 degrees ± 0.2 degree, 22.4 degrees ± 0.2 degree, 25.7 degrees ± 0.2 degree and 26.4 degrees ± 0.2 degree. The novel crystal form of the dextro borneol ferulate has better solubleness, better bioavailability, better stability, better tractability and high effect, and has a good application prospect in the field of pharmaceutical preparations.
Inventors:
LI YUNSEN (CN)
CHEN ZIJUN (CN)
DENG SHIPING (CN)
LIU QIAN (CN)
LI YONG (CN)
FENG HAIMEI (CN)
GAO YUAN (CN)
CHEN ZIJUN (CN)
DENG SHIPING (CN)
LIU QIAN (CN)
LI YONG (CN)
FENG HAIMEI (CN)
GAO YUAN (CN)
Application Number:
PCT/CN2016/079861
Publication Date:
November 17, 2016
Filing Date:
April 21, 2016
Export Citation:
Assignee:
SUZHOU PHARMAVAN CANCER RES CENTER CO LTD (CN)
International Classes:
C07C69/734; A61K31/216; A61P3/06; A61P7/02; A61P9/10; C07C67/52
Foreign References:
| CN104910018A | 2015-09-16 | |||
| CN104856983A | 2015-08-26 |
Other References:
LI, LIMEI ET AL.: "Chemical Constituents of Notopterygium incisum", CHINESE JOURNAL OF NATURAL MEDICINES, vol. 5, 20 September 2007 (2007-09-20), pages 351 - 353
TOYOTA, M. ET AL.: "A comparative study on three chemo-types of the liverwort Conocephalum conicum using volatile constituents", PHYTOCHEMISTRY, vol. 44, no. 7, XP004293038
BOHLMANN, F. ET AL.: "Eudesmane derivatives from verbesina species", PHYTOCHEMISTRY, vol. 19, no. 11, 31 December 1980 (1980-12-31), pages 2391 - 2397, XP055328414
MA, FENGSHI ET AL.: "The Research Progresses of Ferulic Acid Derivatives and its Bioactivities", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 32, no. 8, 25 August 2008 (2008-08-25), pages 345 - 350, ISSN: 1001-5094
TOYOTA, M. ET AL.: "A comparative study on three chemo-types of the liverwort Conocephalum conicum using volatile constituents", PHYTOCHEMISTRY, vol. 44, no. 7, XP004293038
BOHLMANN, F. ET AL.: "Eudesmane derivatives from verbesina species", PHYTOCHEMISTRY, vol. 19, no. 11, 31 December 1980 (1980-12-31), pages 2391 - 2397, XP055328414
MA, FENGSHI ET AL.: "The Research Progresses of Ferulic Acid Derivatives and its Bioactivities", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 32, no. 8, 25 August 2008 (2008-08-25), pages 345 - 350, ISSN: 1001-5094
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
北京品源专利代理有限公司 (CN)
北京品源专利代理有限公司 (CN)
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