Title:
DI -ASPIRIN DERIVATIVES FOR USE IN THE TREATMENT OF COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2011/098839
Kind Code:
A3
Abstract:
The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di-aspirin and its derivatives.
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Inventors:
PERRY CHRISTOPHER JOHN (GB)
NICHOLL IAIN DOUGLAS (GB)
NICHOLL IAIN DOUGLAS (GB)
Application Number:
PCT/GB2011/050284
Publication Date:
November 03, 2011
Filing Date:
February 15, 2011
Export Citation:
Assignee:
UNIV WOLVERHAMPTON (GB)
PERRY CHRISTOPHER JOHN (GB)
NICHOLL IAIN DOUGLAS (GB)
PERRY CHRISTOPHER JOHN (GB)
NICHOLL IAIN DOUGLAS (GB)
International Classes:
A61K31/60; A61K31/609; A61K31/616; A61K31/621; A61P35/00; C07C69/86; C07C69/96; C07C203/04; C07C205/43; C07C235/60
Domestic Patent References:
| WO2005076987A2 | 2005-08-25 |
Other References:
KAHNS, ANNE H. ET AL: "N-Acyl derivatives as prodrug forms for amides: chemical stability and enzymic hydrolysis of various N-acyl and N-alkoxycarbonyl amide derivatives", INTERNATIONAL JOURNAL OF PHARMACEUTICS , 71(1-2), 31-43 CODEN: IJPHDE; ISSN: 0378-5173, 1991, XP002640016
"The Merck Index,thirteenth Edition", 2001, MERCK & CO., INC., pages: 1494, XP002640017
CHANG A T ET AL: "Aspirin Use and Survival After Diagnosis of Colorectal Cancer", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, vol. 302, no. 6, 12 August 2009 (2009-08-12), pages 649 - 659, XP009123039, ISSN: 0098-7484
KRISHNAN K ET AL: "ASPIRIN AND OTHER PROSTAGLANDIN INHIBITORS FOR THE PREVENTION OF COLON CANCER", INFUSION CHEMOTHERAPY - IRRADIATION INTERACTIONS, XX, XX, 1 January 1998 (1998-01-01), pages 405 - 422, XP009046860
KIM Y H ET AL: "Inhibition of cell proliferation and invasion in a human colon cancer cell line by 5-aminosalicylic acid", DIGESTIVE AND LIVER DISEASE, W.B. SAUNDERS, GB, vol. 41, no. 5, 1 May 2009 (2009-05-01), pages 328 - 337, XP026070392, ISSN: 1590-8658, [retrieved on 20081031], DOI: DOI:10.1016/J.DLD.2008.09.003
"The Merck Index,thirteenth Edition", 2001, MERCK & CO., INC., pages: 1494, XP002640017
CHANG A T ET AL: "Aspirin Use and Survival After Diagnosis of Colorectal Cancer", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, vol. 302, no. 6, 12 August 2009 (2009-08-12), pages 649 - 659, XP009123039, ISSN: 0098-7484
KRISHNAN K ET AL: "ASPIRIN AND OTHER PROSTAGLANDIN INHIBITORS FOR THE PREVENTION OF COLON CANCER", INFUSION CHEMOTHERAPY - IRRADIATION INTERACTIONS, XX, XX, 1 January 1998 (1998-01-01), pages 405 - 422, XP009046860
KIM Y H ET AL: "Inhibition of cell proliferation and invasion in a human colon cancer cell line by 5-aminosalicylic acid", DIGESTIVE AND LIVER DISEASE, W.B. SAUNDERS, GB, vol. 41, no. 5, 1 May 2009 (2009-05-01), pages 328 - 337, XP026070392, ISSN: 1590-8658, [retrieved on 20081031], DOI: DOI:10.1016/J.DLD.2008.09.003
Attorney, Agent or Firm:
BARKER BRETTELL LLP (EgbastonBirmingham, West Midlands B16 8QQ, GB)
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