Title:
PREVENTIVES/REMEDIES FOR DIABETES
Document Type and Number:
WIPO Patent Application WO/1999/029324
Kind Code:
A1
Abstract:
Drugs containing as the active ingredient compounds represented by general formula (I and II) and being useful in preventing and treating diabetes and complication thereof, wherein R?1¿ represents hydrogen or C¿1-6? alkyl; R?2¿ and R?3¿ represent each hydrogen or C¿1-6? alkyl, or R?2¿ and R?3¿ may form together with the carbon atom on the phenyl ring to which they are bonded a 5- or 6-membered ring; R?4¿ represents hydrogen, C¿1-6? alkyl, C¿1-6? alkoxy, etc.; R?6¿ represents hydrogen or C¿1-6? alkyl; X represents -NR?7¿-, -NO-, -O-, etc. (wherein R?7¿ represents hydrogen, C¿1-6? alkyl, etc.); and Y represents phenylene or pyridinediyl.
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Inventors:
KAGECHIKA HIROYUKI (JP)
HASHIMOTO YUICHI (JP)
FUJII HIDEJI (JP)
YONEKAWA YOSHIAKI (JP)
EKIMOTO HISAO (JP)
HASHIMOTO YUICHI (JP)
FUJII HIDEJI (JP)
YONEKAWA YOSHIAKI (JP)
EKIMOTO HISAO (JP)
Application Number:
PCT/JP1998/005480
Publication Date:
June 17, 1999
Filing Date:
December 04, 1998
Export Citation:
Assignee:
INST MED MOLECULAR DESIGN INC (JP)
KAGECHIKA HIROYUKI (JP)
HASHIMOTO YUICHI (JP)
FUJII HIDEJI (JP)
YONEKAWA YOSHIAKI (JP)
EKIMOTO HISAO (JP)
KAGECHIKA HIROYUKI (JP)
HASHIMOTO YUICHI (JP)
FUJII HIDEJI (JP)
YONEKAWA YOSHIAKI (JP)
EKIMOTO HISAO (JP)
International Classes:
A61K31/55; A61K31/551; A61K31/5513; A61K31/553; A61K31/554; A61P3/06; A61P3/08; A61P3/10; C07D243/24; C07D243/38; (IPC1-7): A61K31/55
Domestic Patent References:
| WO1998045242A1 | 1998-10-15 | |||
| WO1997012853A1 | 1997-04-10 |
Foreign References:
| JPH10114757A | 1998-05-06 | |||
| JPH09100270A | 1997-04-15 |
Other References:
HIROKI UMEMIYA, ET AL.: "REGULATION OF RETINOIDAL ACTIONS BY DIAZEPINYLBENZOIC ACIDS RETINOID SYNERGISTS WHICH ACTIVATE THE RXR-RAR HETERODIMERS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 40, no. 26, 1 January 1997 (1997-01-01), US, pages 4222 - 4234, XP002918197, ISSN: 0022-2623, DOI: 10.1021/jm9704309
UMEMIYA H, ET AL.: "SYNERGISTS FOR RETINOID IN CELLULAR DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA CELLS HL-60", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 43, no. 10, 1 January 1995 (1995-01-01), JP, pages 1827 - 1829, XP002918198, ISSN: 0009-2363
EYROLLES L., ET AL.: "RETINOBENZOIC ACIDS. 6. RETINOID ANTOGONISTS WITH A HETEROCYCLIC RING.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37., no. 10., 1 January 1994 (1994-01-01), US, pages 1508 - 1517., XP002918199, ISSN: 0022-2623, DOI: 10.1021/jm00036a017
See also references of EP 1036565A4
UMEMIYA H, ET AL.: "SYNERGISTS FOR RETINOID IN CELLULAR DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA CELLS HL-60", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 43, no. 10, 1 January 1995 (1995-01-01), JP, pages 1827 - 1829, XP002918198, ISSN: 0009-2363
EYROLLES L., ET AL.: "RETINOBENZOIC ACIDS. 6. RETINOID ANTOGONISTS WITH A HETEROCYCLIC RING.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37., no. 10., 1 January 1994 (1994-01-01), US, pages 1508 - 1517., XP002918199, ISSN: 0022-2623, DOI: 10.1021/jm00036a017
See also references of EP 1036565A4
Attorney, Agent or Firm:
Imamura, Masazumi (Kyobashi 1-chome Chuo-ku Tokyo, JP)
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