Title:
DIAGNOSING ASTHMA PATIENTS PREDISPOSED TO ADVERSE BETA -AGONIST REACTIONS
Document Type and Number:
WIPO Patent Application WO1998039477
Kind Code:
A3
Abstract:
The present invention provides a novel method for identifying individuals who are likely to have negative responses to regular administration of beta -agonists. The invention also provides kits useful for this purpose.
Inventors:
DRAZEN JEFFREY M
CHINCHILLI VERNON M
MARTIN RICHARD J
FORD JEAN G
FISH JAMES E
BOUSHEY HOMER
CHINCHILLI VERNON M
MARTIN RICHARD J
FORD JEAN G
FISH JAMES E
BOUSHEY HOMER
Application Number:
PCT/US1998/003908
Publication Date:
December 17, 1998
Filing Date:
February 26, 1998
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
International Classes:
C12Q1/68; C12N15/09; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO1996025517A1 | 1996-08-22 |
Other References:
DRAZEN J ET AL: "Comparison of regularly scheduled with as-needed use of Albuterol in mild asthma", NEW ENGLAND JOURNAL OF MEDICINE, vol. 335, no. 12, 19 September 1996 (1996-09-19), pages 841 - 7, XP002079181
KAMADA A ET AL: "Issues in the use of inhaled glucocorticoids, the asthma clinical research network", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 153, no. (6 pt 1), June 1996 (1996-06-01), pages 1739 - 48, XP002079182
GREEN S ET AL: "Influence of beta-2 adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 13, no. 1, July 1995 (1995-07-01), pages 25-33, XP002079183
GREEN S ET AL: "Implications of genetic variability of human beta-2 adrenergic structure", PULMONARY PHARMACOLOGY, vol. 8, no. 1, February 1995 (1995-02-01), pages 1-10, XP002079184
KAMADA A ET AL: "Issues in the use of inhaled glucocorticoids, the asthma clinical research network", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 153, no. (6 pt 1), June 1996 (1996-06-01), pages 1739 - 48, XP002079182
GREEN S ET AL: "Influence of beta-2 adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 13, no. 1, July 1995 (1995-07-01), pages 25-33, XP002079183
GREEN S ET AL: "Implications of genetic variability of human beta-2 adrenergic structure", PULMONARY PHARMACOLOGY, vol. 8, no. 1, February 1995 (1995-02-01), pages 1-10, XP002079184
Download PDF:
Previous Patent: METHOD OF IDENTIFYING GENE ENCODING TYPE II MEMBRANE PROTEIN
Next Patent: CONTIGUOUS GENOMIC SEQUENCE SCANNING
Next Patent: CONTIGUOUS GENOMIC SEQUENCE SCANNING