Title:
DIAGNOSING AND TREATING DILATED CARDIOMYOPATHY BASED ON RAF1 MUTATIONS
Document Type and Number:
WIPO Patent Application WO/2014/204938
Kind Code:
A3
Abstract:
The present invention is directed to methods of diagnosing and treating subjects with dilated cardiomyopathy. The diagnostic and therapeutic applications are based on mutations in RAF1. A method for identifying compounds useful in treatment of dilated cardiomyopathy is also disclosed.
Inventors:
GELB BRUCE D (US)
DHANDAPANY PERUNDURAI S (IN)
DHANDAPANY PERUNDURAI S (IN)
Application Number:
PCT/US2014/042700
Publication Date:
March 12, 2015
Filing Date:
June 17, 2014
Export Citation:
Assignee:
ICAHN SCHOOL MED MOUNT SINAI (US)
International Classes:
C12Q1/68
Foreign References:
| US20100009361A1 | 2010-01-14 | |||
| US20070258951A1 | 2007-11-08 |
Other References:
YAMAGUCHI ET AL.: "Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis", J. CLIN. INVEST., vol. 114, 2004, pages 937 - 943
DUMAZ ET AL.: "Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.", MOLECULAR AND CELLULAR BIOLOGY 22.11, vol. 3717-372, 2002, pages 3722
DUMAZ ET AL.: "Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.", MOLECULAR AND CELLULAR BIOLOGY 22.11, vol. 3717-372, 2002, pages 3722
Attorney, Agent or Firm:
GOLDMAN, Michael, L. et al. (70 Linden OaksSuite 210, Rocheste, New York NY, US)
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