Title:
DIAGNOSIS ACCURACY IMPROVING COMPOSITION FOR USE IN MAGNIFICATION ENDOSCOPY OR ULTRA-HIGH MAGNIFICATION ENDOSCOPY
Document Type and Number:
WIPO Patent Application WO/2022/059728
Kind Code:
A1
Abstract:
For the diagnosis of gastric cancer by a magnification endoscopy with narrow-band imaging or an ultra-high magnification endoscopy with narrow-band imaging in each of which observation is performed with narrow-band light, a method having high diagnostic accuracy is established. It becomes possible to perform the examination without enhancing the production of a mucus by administering pronase orally prior to the endoscopy and optionally administering pronase typically under the observation with the endoscope, without the need to stain with a dye unlike the case of other organs. In the conventional endoscopic examinations, a lesion is identified and then a definitive diagnosis is performed by a pathological examination. In contrast, when the method of the present invention is employed, possibilities that high diagnosis performance might be achieved and the diagnosis with accuracy similar to that achieved in a pathological examination might be achieved with an endoscope have been suggested. The removal of a mucus with pronase is useful in a magnification endoscopy or an ultra-high magnification endoscopy.
Inventors:
HORIUCHI YUSUKE (JP)
Application Number:
PCT/JP2021/034040
Publication Date:
March 24, 2022
Filing Date:
September 16, 2021
Export Citation:
Assignee:
KAKEN PHARMA CO LTD (JP)
JAPANESE FOUND FOR CANCER RES (JP)
JAPANESE FOUND FOR CANCER RES (JP)
International Classes:
A61K9/08; A61B1/00; A61K38/48; A61K47/02; A61K47/22; A61K49/00; A61K49/04
Domestic Patent References:
| WO2017200066A1 | 2017-11-23 |
Other References:
FUNATSU KAZUO, MAEZAWA JUNKO, AKIYAMA YUKARI, YAMASHITA TAKESHI, KONDO SYUJI, OHARA KEIKO, YOKOYAMA MASAKO, MIZUNO KYOUICHI: "Clinical usefulness of simple pretreatment with pronase to improve endoscopic observation of the gastric mucosa", HEALTH EVALUATION AND PROMOTION : HEP, vol. 43, no. 6, 1 January 2016 (2016-01-01), Japan, pages 17 (665) - 22 (670), XP009535580, ISSN: 1347-0086, DOI: 10.7143/jhep.43.665
EZOE Y. ET AL., GASTROENTEROLOGY, vol. 141, 2011, pages 2017 - 2025
YAO K. ET AL., ENDOSCOPY, vol. 41, 2009, pages 462 - 467
KUMAGAI Y. ET AL., ENDOSCOPY, vol. 36, 2004, pages 590 - 594
INOUE H. ET AL., GASTROINTEST ENDOSC. CLIN. N. AM., vol. 14, 2004, pages 589 - 594
NAKANISHI H. ET AL., ENDOSCOPY, vol. 49, 2017, pages 957 - 180
SASAJIMA K. ET AL., GASTROINTEST. ENDOSC., vol. 63, 2006, pages 1010 - 1017
SAKO T. ET AL., ENDOSCOPY, vol. 50, 2018, pages 69 - 74
KUDO S.E. ET AL., GASTROINTEST. ENDOSC., vol. 82, 2015, pages 912 - 923
KAISE M. ET AL., ENDOSCOPY, vol. 47, 2015, pages 19 - 25
ABAD M.R.A. ET AL., TRANSL. GASTROENTEROL. HEPATOL., vol. 5, 2020, pages 28
MUTO M. ET AL., DIG. ENDOSC., vol. 28, 2016, pages 379 - 393
EZOE Y. ET AL., GASTROENTEROLOGY, vol. 141, 2011, pages 2017 - 2025
YAO K. ET AL., ENDOSCOPY, vol. 41, 2009, pages 462 - 467
KUMAGAI Y. ET AL., ENDOSCOPY, vol. 36, 2004, pages 590 - 594
INOUE H. ET AL., GASTROINTEST ENDOSC. CLIN. N. AM., vol. 14, 2004, pages 589 - 594
NAKANISHI H. ET AL., ENDOSCOPY, vol. 49, 2017, pages 957 - 180
SASAJIMA K. ET AL., GASTROINTEST. ENDOSC., vol. 63, 2006, pages 1010 - 1017
SAKO T. ET AL., ENDOSCOPY, vol. 50, 2018, pages 69 - 74
KUDO S.E. ET AL., GASTROINTEST. ENDOSC., vol. 82, 2015, pages 912 - 923
KAISE M. ET AL., ENDOSCOPY, vol. 47, 2015, pages 19 - 25
ABAD M.R.A. ET AL., TRANSL. GASTROENTEROL. HEPATOL., vol. 5, 2020, pages 28
MUTO M. ET AL., DIG. ENDOSC., vol. 28, 2016, pages 379 - 393
Attorney, Agent or Firm:
SHIRAKATA Yumiko (JP)
Download PDF:
Previous Patent: FUNCTIONAL COMPONENT-IMPREGNATED HOLLOW XONOTLITE BODY
Next Patent: LIQUID DISCHARGING CONTAINER
Next Patent: LIQUID DISCHARGING CONTAINER