Title:
DIAGNOSIS OF ACUTE ENTERITIS BY DETERMINATION OF INTESTINAL FATTY ACID-BINDING PROTEIN IN THE BLOOD
Document Type and Number:
WIPO Patent Application WO/2007/119481
Kind Code:
A1
Abstract:
Disclosed is a rapid and simple determination method for acute enteritis which can determine acute enteritis in a quantitative and objective manner. Also disclosed is a reagent for the determination. Detection of I-FABP is made in the separated blood. Preferably, the blood is human blood, the I-FABP is human I-FABP, and the detection of I-FABP in the blood is performed by an immunochemical method. The immunochemical method may be any one of an enzyme immunochemical assay, a latex agglutination assay and an immunochromatographic assay, and is preferably an enzyme immunochemical assay, more preferably a sandwich enzyme immunoassay.
Inventors:
KANDA TATSUO (JP)
FUJII HIROSHI (JP)
FUNAOKA HIROYUKI (JP)
KAJIURA SATOSHI (JP)
OHKARU YASUHIKO (JP)
FUJII HIROSHI (JP)
FUNAOKA HIROYUKI (JP)
KAJIURA SATOSHI (JP)
OHKARU YASUHIKO (JP)
Application Number:
PCT/JP2007/055865
Publication Date:
October 25, 2007
Filing Date:
March 22, 2007
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
KANDA TATSUO (JP)
FUJII HIROSHI (JP)
FUNAOKA HIROYUKI (JP)
KAJIURA SATOSHI (JP)
OHKARU YASUHIKO (JP)
KANDA TATSUO (JP)
FUJII HIROSHI (JP)
FUNAOKA HIROYUKI (JP)
KAJIURA SATOSHI (JP)
OHKARU YASUHIKO (JP)
International Classes:
G01N33/53; G01N33/543
Domestic Patent References:
| WO1993008276A1 | 1993-04-29 | |||
| WO2003083486A1 | 2003-10-09 | |||
| WO1993008276A1 | 1993-04-29 |
Foreign References:
| US5225329A | 1993-07-06 | |||
| JP2006079565A | 2006-03-23 |
Other References:
GUTHMANN F. ET AL.: "Plasma concentration of intestinal and liver-FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 239, no. 1-2, 2002, pages 227 - 234, XP003018836
FUJII H.: "Lipid Biofactor no Kino Hatsugen ni Kan'yo suru Tanpakushitsugun no Kenkyu", KANAE IGAKU JOSEIKIN JUSHOSHA KENKYU GYOSEKISHU, vol. 23RD, 1 October 1996 (1996-10-01), pages 419 - 431, XP003018837
See also references of EP 2006682A4
TATSUO KANDA; HIROSHI FUJII ET AL.: "Intestinal Fatty Acid-Binding Protein Is a Useful Diagnostic Marker for Mesenteric Infarction in Humans.", GASTROENTEROLOGY, vol. 110, 1996, pages 339 - 343
JOSHUA M. LIBERMAN ET AL.: "Human intestinal fatty acid binding protein:Report of an assay with studies in normal volunteers and intestinal ischemia.", SURGERY, vol. 121, no. 3, 1997, pages 335 - 342
FLORIAN GUTHMANN ET AL.: "Plasma concentration of intestinal-and liver-FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates.", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 239, 2002, pages 227 - 234
TATSUO KANDA; TERUO ONO ET AL.: "Possible role of rat fatty acid-binding proteins in the intestine as carriers of phenol and phthalate derivatives.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 168, 1990, pages 1053 - 1058
FUJII H.: "Lipid Biofactor no Kino Hatsugen ni Kan'yo suru Tanpakushitsugun no Kenkyu", KANAE IGAKU JOSEIKIN JUSHOSHA KENKYU GYOSEKISHU, vol. 23RD, 1 October 1996 (1996-10-01), pages 419 - 431, XP003018837
See also references of EP 2006682A4
TATSUO KANDA; HIROSHI FUJII ET AL.: "Intestinal Fatty Acid-Binding Protein Is a Useful Diagnostic Marker for Mesenteric Infarction in Humans.", GASTROENTEROLOGY, vol. 110, 1996, pages 339 - 343
JOSHUA M. LIBERMAN ET AL.: "Human intestinal fatty acid binding protein:Report of an assay with studies in normal volunteers and intestinal ischemia.", SURGERY, vol. 121, no. 3, 1997, pages 335 - 342
FLORIAN GUTHMANN ET AL.: "Plasma concentration of intestinal-and liver-FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates.", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 239, 2002, pages 227 - 234
TATSUO KANDA; TERUO ONO ET AL.: "Possible role of rat fatty acid-binding proteins in the intestine as carriers of phenol and phthalate derivatives.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 168, 1990, pages 1053 - 1058
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka 44, JP)
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