Title:
DIAGNOSIS OF CLEAR CELL TYPE RENAL CARCINOMA
Document Type and Number:
WIPO Patent Application WO1999009205
Kind Code:
A3
Abstract:
Method for detecting clear cell type renal carcinoma in a mammal comprising determining the concentration of Na,K-ATPase's beta -subunit in a biological sample. Alternatively the concentration of N-linked sugar residues, lactosamine residues, sialic acid residues, or combinations thereof in Na,K-ATPase's beta -subunit in the biological sample is determined and correlated with the presence of clear cell type renal carcinoma in the mammal. The method further includes detecting the Na,K-ATPase's spatial distribution in the tissue section by detecting the biological agent's spatial distribution in the tissue and correlating the Na,K-ATPase's spatial distribution in the tissue section to the presence of clear cell type renal carcinoma in the mammal. In addition, a kit for detecting clear cell type renal carcinoma is disclosed. The kit includes an agent capable of cleaving N-linked sugar residues, lactosamine residues, sialic acid, or combinations thereof and a biological agent which binds to Na,K-ATPase.
Inventors:
RAJASEKARAN AYYAPPAN K
RAJASEKARAN SIGRID A
BANDER NEIL H
PARDEE JOEL D
BALL WILLIAM J
RAJASEKARAN SIGRID A
BANDER NEIL H
PARDEE JOEL D
BALL WILLIAM J
Application Number:
PCT/US1998/017253
Publication Date:
May 20, 1999
Filing Date:
August 20, 1998
Export Citation:
Assignee:
CORNELL RES FOUNDATION INC (US)
UNIV CINCINNATI (US)
UNIV CINCINNATI (US)
International Classes:
F04C27/00; (IPC1-7): G01N33/574
Other References:
AKOPYANZ N S ET AL: "Tissue-specific expression of Na,K- ATPase beta-subunit. Does beta 2 expression correlate with tumorigenesis ?.", FEBS LETTERS, (1991 SEP 2) 289 (1) 8-10. JOURNAL CODE: EUH. ISSN: 0014-5793., Netherlands, XP002095674
DATABASE MEDLINE US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; SVERDLOV E D ET AL: "[Differential expression of 2 genes of the Na+,K+- AtPase subuni in normal and tumor tissues in humans]. Differentsial'naia ekspressiia dvukh genov alpha-sub''edinitsy Na+,K+-ATFazy v normal'nykh i opukholevykh tkaniakh cheloveka.", XP002095675
DATABASE MEDLINE US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; SVERDLOV E D ET AL: "[Differential expression of 2 genes of the Na+,K+- AtPase subuni in normal and tumor tissues in humans]. Differentsial'naia ekspressiia dvukh genov alpha-sub''edinitsy Na+,K+-ATFazy v normal'nykh i opukholevykh tkaniakh cheloveka.", XP002095675
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