Title:
DIAGNOSIS METHOD AND THERAPEUTIC METHOD FOR CANCER
Document Type and Number:
WIPO Patent Application WO/2010/032696
Kind Code:
A1
Abstract:
Disclosed are a diagnosis method and a therapeutic method for cancer, both of which utilize HERV-H env gene and protein. Particularly, cancer can be diagnosed by detecting the expression of HERV-H env gene, and a reagent used for the detection of the expression can be used as a diagnosing agent. Cancer can be treated by inhibiting the function of HERV-H env gene, and a reagent used for the inhibition of the function can be used as an anti-cancer agent. Alternatively, cancer can be treated by administering a peptide having a specific sequence contained in HERV-H env protein or the like, and the peptide or the like can be used as a cancer vaccine.
Inventors:
KUDO CHIE (JP)
KAWAKAMI YUTAKA (JP)
KAWAKAMI YUTAKA (JP)
Application Number:
PCT/JP2009/065955
Publication Date:
March 25, 2010
Filing Date:
September 11, 2009
Export Citation:
Assignee:
UNIV KEIO (JP)
KUDO CHIE (JP)
KAWAKAMI YUTAKA (JP)
KUDO CHIE (JP)
KAWAKAMI YUTAKA (JP)
International Classes:
A61K45/00; A61K31/713; A61K35/12; A61K35/14; A61K35/15; A61K35/17; A61K35/76; A61K39/00; A61K48/00; A61P35/00; A61P35/02; A61P37/04; C07K14/15; C12N5/10; C12N15/09; C12Q1/68
Domestic Patent References:
| WO2006077941A1 | 2006-07-27 |
Foreign References:
| JP2007246451A | 2007-09-27 | |||
| JP2004502407A | 2004-01-29 | |||
| JP2008239943A | 2008-10-09 |
Other References:
MARIANNE MANGENEY ET AL.: "The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties", JOURNAL OF GENERAL VIROLOGY, vol. 82, 2001, pages 2515 - 2518, XP002298110
MATS LINDESKOG ET AL.: "Isolation of a human endogenous retroviral HERV-H element with an open env reading frame", VIROLOGY, vol. 258, 1999, pages 441 - 450, XP004439914
PATRIC JERN ET AL.: "Sequence Variability, Gene Structure, and Expression of Full-Length Human Endogenous Retrovirus H", JOURNAL OF VIROLOGY, vol. 79, no. 10, 2005, pages 6325 - 6337, XP055018133
NATHALIE DE PARSEVAL ET AL.: "Characterization of the Three HERV-H Proviruses with an Open Envelope Reading Frame Encompassing the Immunosuppressive Domain and Evolutionary History in Primates", VIROLOGY, vol. 279, 2001, pages 558 - 569, XP055018094
YI, J-M, KIM, H-M, KIM, H-S, TUMOR LETTERS, vol. 231, 2006, pages 228 - 239
NATURE REV TUMOR, vol. 7, 2007, pages 415 - 428
"Molecular cloning, a laboratory manual", 2001, COLD SPRING HARBOR PRESS
"Current Protocols in Molecular Biology", JOHN WILEY & SONS LTD.
INTERNATIONAL J. TUMOR, vol. 100, 2002, pages 5565 - 5570
CANCER RESEARCH, vol. 60, 2000, pages 3848 - 3855
See also references of EP 2340851A4
MATS LINDESKOG ET AL.: "Isolation of a human endogenous retroviral HERV-H element with an open env reading frame", VIROLOGY, vol. 258, 1999, pages 441 - 450, XP004439914
PATRIC JERN ET AL.: "Sequence Variability, Gene Structure, and Expression of Full-Length Human Endogenous Retrovirus H", JOURNAL OF VIROLOGY, vol. 79, no. 10, 2005, pages 6325 - 6337, XP055018133
NATHALIE DE PARSEVAL ET AL.: "Characterization of the Three HERV-H Proviruses with an Open Envelope Reading Frame Encompassing the Immunosuppressive Domain and Evolutionary History in Primates", VIROLOGY, vol. 279, 2001, pages 558 - 569, XP055018094
YI, J-M, KIM, H-M, KIM, H-S, TUMOR LETTERS, vol. 231, 2006, pages 228 - 239
NATURE REV TUMOR, vol. 7, 2007, pages 415 - 428
"Molecular cloning, a laboratory manual", 2001, COLD SPRING HARBOR PRESS
"Current Protocols in Molecular Biology", JOHN WILEY & SONS LTD.
INTERNATIONAL J. TUMOR, vol. 100, 2002, pages 5565 - 5570
CANCER RESEARCH, vol. 60, 2000, pages 3848 - 3855
See also references of EP 2340851A4
Attorney, Agent or Firm:
ISSHIKI & CO. (JP)
All international patent business corporation (JP)
All international patent business corporation (JP)
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