Title:
DIAGNOSIS OF PRE-CANCEROUS CONDITIONS USING PCDGF AGENTS
Document Type and Number:
WIPO Patent Application WO2005009217
Kind Code:
A3
Abstract:
The present invention relates to methods and compositions designed for the treatment or management of pre-cancerous conditions, especially in order to prevent, delay, or decrease the likelihood that the pre-cancerous condition will progress to malignant cancer. The methods of the invention comprise the administration of an effective amount of one or more agents that decrease/inhibit PCDGF expression, secretion, and/or activity. The invention also provides pharmaceutical compositions comprising one or more PCDGF agents. In some embodiments, the PCDGF agents can be administered with other therapeutic agents for treatment or management of a pre-cancerous condition that are not PCDGF-based. Diagnostic methods and methods for screening for therapeutically useful PCDGF agents are also provided.
Inventors:
KINCH MICHAEL S (US)
Application Number:
PCT/US2004/023191
Publication Date:
May 26, 2005
Filing Date:
July 16, 2004
Export Citation:
Assignee:
MEDIMMUNE INC (US)
KINCH MICHAEL S (US)
KINCH MICHAEL S (US)
International Classes:
A61K38/00; A61K39/395; A61K48/00; C07H21/04; C07K1/00; C07K2/00; C07K4/00; C07K5/00; C07K7/00; C07K14/00; C07K16/00; C07K17/00; C12Q1/00; G01N33/50; G01N33/574; A61B; A61K; (IPC1-7): A61K38/00; C07K1/00; C07K2/00; C07K4/00; C07K5/00; C07K7/00; C07K14/00; C07K16/00; C07K17/00; C12Q1/00
Other References:
PAN ET AL.: "PC cell-derived growth factor expression in prostatic intraepihelial neoplasia and prostatic adenocarcinoma", CLINICAL CANCER RES., vol. 10, 15 February 2004 (2004-02-15), pages 1333 - 1337, XP002985821
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