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Title:
DIAGNOSTIC AGENT FOR SEPSIS
Document Type and Number:
WIPO Patent Application WO/2018/088455
Kind Code:
A1
Abstract:
To develop a novel biomarker that is useful in diagnosing sepsis and provide a diagnostic agent and diagnostic method therefor. A method for diagnosing sepsis, said method comprising measuring a component selected from carbonic anhydrase 1 and leucine-rich α-2-glycoprotein in a blood sample.

Inventors:
NAKADA, Taka-aki (National University Corporation Chiba University 1-8-1, Inohana, Chuo-ku, Chiba-sh, Chiba 77, 〒2608677, JP)
HASHIDA, Tomoaki (National University Corporation Chiba University 1-8-1, Inohana, Chuo-ku, Chiba-sh, Chiba 77, 〒2608677, JP)
Application Number:
JP2017/040348
Publication Date:
May 17, 2018
Filing Date:
November 09, 2017
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (1-33, Yayoi-cho Inage-ku, Chiba-sh, Chiba 22, 〒2638522, JP)
International Classes:
G01N33/68; C07K2/00; C12N9/88; G01N33/53; G01N33/573
Domestic Patent References:
WO2013152047A12013-10-10
Foreign References:
JP2005512060A2005-04-28
JP4643445B22011-03-02
Other References:
NAKATA, TAKAAKI: "Proteome analysis of substances adsorbed to blood purification membrane", JAPANESE JOURNAL OF ARTIFICIAL ORGANS, vol. 45, no. 2, 31 October 2016 (2016-10-31), pages 132 017 - 4
MACALLAN, D. C.: "The effect of endotoxin on skeletal muscle protein gene expression in the rat", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 28, no. 5, May 1996 (1996-05-01), pages 511 - 520, XP055502600
REDINA, L. V.: "The carbonic anhydrase of the blood of the newborn and its diagnostic significance", AKUSHERSTVO I GINEKOLOGIYA (MOSCOW, vol. 1, 1948, pages 40 - 42, ISSN: 0002-3906
KREPS, E. M.: "The respiratory ferment carbonic anhydrase and its diagnostic significance in sepsis", KHIRIRUGIIA, vol. 5, 1945, pages 22 - 25, ISSN: 0023-1207
HASHIDA, TOMOAKI: "Proteomic analysis of substances adsorbed to blood purification membrane in sepsis", JOURNAL OF JAPAN SOCIETY FOR BLOOD PURIFICATION IN CRITICAL CARE, vol. 6, 15 September 2015 (2015-09-15)
HATTORI, NORIYUK: "Method for purifying blood against septic shock", JOURNAL OF JAPAN SOCIETY FOR BLOOD PURIFICATION IN CRITICAL CARE, vol. 7, 15 September 2016 (2016-09-15), pages 44
HASHIDA, TOMOAKI: "Proteome analysis of hemofilter adsorbates to identify novel substances of sepsis: a pilot study", JOURNAL OF ARTIFICIAL ORGANS, vol. 20, no. 2, 17 November 2016 (2016-11-17), pages 132 - 137, XP036246869
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Sawanotsuru Ningyocho Bldg, 1-3-8 Nihonbashi Ningyocho, Chuo-k, Tokyo 13, 〒1030013, JP)
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