DIAGNOSTIC ASSAY REQUIRING A SMALL SAMPLE OF BIOLOGICAL FLUID

Title:

DIAGNOSTIC ASSAY REQUIRING A SMALL SAMPLE OF BIOLOGICAL FLUID

Document Type and Number:

WIPO Patent Application WO1999064620

Kind Code:

A3

Abstract:

A multiple-layer element method for monitoring the concentration of glucose in blood. The element comprises: (a) a core layer having two major surfaces, an optical reading chamber extending from a first opening in one of said two major surfaces to a second opening in the other of said two major surfaces, said, core layer further having a third opening therein and a flow channel, one end of which flow channel communicates with the third opening and the other end of which flow channel communicates with the optical reading chamber; and (b) a base layer in face-to-face contact with one major surface of said core layer; and (c) a cover layer in face-to-face contact with the other major surface of said core layer, said cover layer having an opening therein to vent the element. The method involves (a) obtaining a sample of biological fluid, e.g., interstitial fluid, from the body of a patient; (b) introducing the sample to article comprising a multiple-layer element having an optical reading chamber; (c) allowing reagents to react with an analyse of interest in the sample; and (d) measuring the concentration of analyse in the sample by means of an optical instrument.

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Inventors:

WONG SIE TING
HILTIBRAN ROBERT G
HUANG TUNG-MING

Application Number:

PCT/US1999/012294

Publication Date:

January 18, 2001

Filing Date:

June 03, 1999

Export Citation:

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Assignee:

ABBOTT LAB (US)

International Classes:

C12Q1/32; C12Q1/54; G01N33/53; G01N33/52; G01N33/543; G01N33/66; G01N37/00; (IPC1-7): G01N33/543; G01N33/53; C12Q1/54

Domestic Patent References:

WO1998035225A1

1998-08-13

Foreign References:

EP0422708A2	1991-04-17
US4876067A	1989-10-24
EP0821233A2	1998-01-28
US5801057A	1998-09-01

Other References:

DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CURME, HENRY G. ET AL: "Multilayer film elements for clinical analysis: general concepts", XP002118481, retrieved from STN Database accession no. 89:142784

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