Title:
DIAGNOSTIC DRUG AND THERAPEUTIC DRUG FOR SMALL CELL LUNG CANCER
Document Type and Number:
WIPO Patent Application WO/2015/012175
Kind Code:
A1
Abstract:
The present invention provides a novel small cell lung cancer marker gene (nSR100 gene) as well as a small cell lung cancer detection method, a small cell lung cancer diagnostic drug and a small cell lung cancer therapeutic drug using same.
Inventors:
SHIMOJO MASAHITO (JP)
Application Number:
PCT/JP2014/068937
Publication Date:
January 29, 2015
Filing Date:
July 16, 2014
Export Citation:
Assignee:
KANSAI MEDICAL UNIVERSITY EDUCATIONAL CORP (JP)
International Classes:
C12N15/09; A61K31/7088; A61K31/713; A61K39/395; A61K48/00; A61P11/00; A61P35/00; C12N15/11; C12N15/113; C12Q1/68; G01N33/53; G01N33/574
Domestic Patent References:
| WO2011076144A1 | 2011-06-30 |
Foreign References:
| JP2009502115A | 2009-01-29 |
Other References:
ORTUNO-PINEDA C. ET AL.: "Binding of hnRNP H and U2AF65 to respective G-codes and a poly- uridine tract collaborate in the N50-5'ss selection of the REST N exon in H69 cells", PLOS ONE, vol. 7, no. 7, 2012, pages 1 - 11
GURROLA-DIAZ C. ET AL.: "Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor alphal subunit in small- cell lung cancer cells", ONCOGENE, vol. 22, no. 36, 2003, pages 5636 - 5645
DU L. ET AL.: "MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs", J. EXP. CLIN. CANCER RES., vol. 29, no. 75, 2010, pages 1 - 12
ZHENG D. ET AL.: "Plasma microRNAs as novel biomarkers for early detection of lung cancer", INT. J. CLIN. EXP. PATHOL., vol. 4, no. 6, 2011, pages 575 - 586
SHIMOJO M. ET AL.: "The small cell lung cancer- specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100", MOL. CANCER RES., vol. 11, no. 10, 2013, pages 1258 - 1268
RAJ B. ET AL.: "Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis", MOL. CELL, vol. 43, no. 5, 2011, pages 843 - 850, XP028279235, DOI: doi:10.1016/j.molcel.2011.08.014
GURROLA-DIAZ C. ET AL.: "Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor alphal subunit in small- cell lung cancer cells", ONCOGENE, vol. 22, no. 36, 2003, pages 5636 - 5645
DU L. ET AL.: "MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs", J. EXP. CLIN. CANCER RES., vol. 29, no. 75, 2010, pages 1 - 12
ZHENG D. ET AL.: "Plasma microRNAs as novel biomarkers for early detection of lung cancer", INT. J. CLIN. EXP. PATHOL., vol. 4, no. 6, 2011, pages 575 - 586
SHIMOJO M. ET AL.: "The small cell lung cancer- specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100", MOL. CANCER RES., vol. 11, no. 10, 2013, pages 1258 - 1268
RAJ B. ET AL.: "Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis", MOL. CELL, vol. 43, no. 5, 2011, pages 843 - 850, XP028279235, DOI: doi:10.1016/j.molcel.2011.08.014
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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