DIAGNOSTIC IMAGING AGENT FOR INCURABLE NEURON DISEASE

WIPO Patent Application WO/2007/111179

A1

The object is to provide: a diagnostic imaging agent for early and accurate diagnosis of a disease associated with the accumulation of amyloid-β protein; and a composition comprising the diagnostic imaging agent. Disclosed is an aminostyrene derivative represented by the formula (I) or a salt thereof: (I) wherein A represent a trifluoromethyl group or a trifluoromethoxy group; X represents O, S or NH; Y represents a nitrogen atom or a carbon atom; R1 and R2 independently represent a hydrogen atom or an alkyl group; m is 0 or 1; n is an integer of 0 to 6; and p is an integer of 0 to 5, provided that p is 0 to 4 when Y is a nitrogen atom.

JP3581713	Trisubstituted phenyl derivative as a phosphodiesterase inhibitor
WO/1997/000859	THIOAMIDES S-OXIDES FOR USE AS PESTICIDES
JPH10168330	SULTONE COMPOUND, QUATERNARY SALT COMPOUND AND METHINE COMPOUND, AND PRODUCTION OF THESE COMPOUNDS, AND SILVER HALIDE PHOTOGRAPHIC PHOTOSENSITIVE MATERIAL CONTAINING THE QUATERNARY SALT COMPOUND AND/OR METHINE COMPOUND

TOOYAMA IKUO (JP)
INUBUSHI TOSHIRO (JP)
MORIKAWA SHIGEHIRO (JP)
TAGUCHI HIROYASU (JP)
SHIRAI NOBUAKI (JP)
OKADA TOSHIKI (JP)
HIRAO KOICHI (JP)
KATO MASANARI (JP)
HAYASHIMOTO AKIO (JP)
KIMURA HIROHIKO (JP)
SANO MITSUO (JP)

PCT/JP2007/055508

October 04, 2007

March 19, 2007

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SHIGA UNIVERSITY OF MEDICAL SC (JP)
SHIGA PREFECTURE (JP)
ISHIHARA SANGYO KAISHA (JP)
TOOYAMA IKUO (JP)
INUBUSHI TOSHIRO (JP)
MORIKAWA SHIGEHIRO (JP)
TAGUCHI HIROYASU (JP)
SHIRAI NOBUAKI (JP)
OKADA TOSHIKI (JP)
HIRAO KOICHI (JP)
KATO MASANARI (JP)
HAYASHIMOTO AKIO (JP)
KIMURA HIROHIKO (JP)
SANO MITSUO (JP)

C07D263/56; A61K49/00; C07D277/64; C07D413/12; G01N33/58; G01N33/68; C07D235/14

WO2003106439A1	2003-12-24
WO2004035522A1	2004-04-29
WO2005042461A1	2005-05-12

OKAMURA N. ET AL.: "Styrylbenzoxazole Derivatives for In Vivo Imaging of Amyloid Plaques in the Brain", THE JOURNAL OF NEUROSCIENCE, vol. 24, no. 10, 10 March 2004 (2004-03-10), pages 2535 - 2541, XP003015010
SHIMADZU H. ET AL.: "Novel probes for imaging amyloid-beta: F-18 and C-11 labeling of 2-(4-aminostyryl)benzoxazole derivatives", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 47, no. 3, 3 February 2004 (2004-02-03), pages 181 - 190, XP003015009
HIGUCHI M. ET AL.: "19F and 1H MRI detection of amyloid beta plaques in vivo", NATURE NEUROSCIENCE, vol. 8, no. 4, April 2005 (2005-04-01), pages 527 - 533, XP003018224

SAEGUSA, Eiji et al. (1-7-1 Doshomachi, Chuo-kuOsaka-sh, Osaka 45, JP)

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