Title:
DIAGNOSTIC IMAGING AGENT FOR OLIGOMERIC AMYLOID
Document Type and Number:
WIPO Patent Application WO/2021/172515
Kind Code:
A9
Abstract:
Disclosed are a diagnostic imaging agent used for detecting oligomeric amyloid-β, with the active ingredient of the diagnostic imaging agent being a curcumin derivative that is present only in a keto form structure or a salt thereof; and a curcumin derivative represented by formula (IA): (in the formula, each R1 is independently a hydrogen atom, a fluorine atom, CH3-, CH2F-, CHF2-, CF3-, CH3O-, CH2FO-, CHF2O-, or CF3O-; each R2 is independently a hydrogen atom or a fluorine atom; A is alkyl, cyano, carboxy, alkoxycarbonyl, or R3-(CH2)m-; R3 is hydroxy, carboxy, cyano, alkylcarbonyloxy, alkoxycarbonyl, alkoxyalkoxy, hydroxyalkoxy, or CONR4R5; R4 and R5 are each independently a hydrogen atom or alkyl; and m is an integer of 1-5 (provided that when R1s are both CH3O- or CF3O-, and R2s are both a hydrogen atom, A must not be CH3-)) or a salt thereof.
Inventors:
TOOYAMA IKUO (JP)
TAGUCHI HIROYASU (JP)
YANAGISAWA DAIJIRO (JP)
KATO TOMOKO (JP)
TAGUCHI HIROYASU (JP)
YANAGISAWA DAIJIRO (JP)
KATO TOMOKO (JP)
Application Number:
PCT/JP2021/007344
Publication Date:
October 21, 2021
Filing Date:
February 26, 2021
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION SHIGA UNIV OF MEDICAL SCIENCE (JP)
International Classes:
A61K49/10; A61B5/055; A61P25/28; C07C49/255; G01N24/08; G01R33/48
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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