Title:
DIAGNOSTIC KIT FOR DIAGNOSING DISORDERS OR DISEASES RELATED TO ABNORMAL PROTEIN AGGREGATION OR MISFOLDING OF PROTEIN USING DISSOLUTION OF PROTEIN AGGREGATES
Document Type and Number:
WIPO Patent Application WO/2014/175693
Kind Code:
A1
Abstract:
The present invention relates to a diagnostic kit for diagnosing disorders or diseases related to abnormal protein aggregation or misfolding of protein by using dissolution of protein aggregates in the body, capable of accurately diagnosing disorders or diseases such as Alzheimer's disease caused by aggregation of beta amyloid, as well as disorders and diseases related to abnormal protein aggregation or misfolding of protein by analyzing concentrations through the dissolution of aggregated protein in the blood of a person having other disorders or diseases due to protein aggregation.
Inventors:
KIM YOUNG SOO (KR)
KIM DONG JIN (KR)
KIM HYE YUN (KR)
CHO SOO MIN (KR)
KIM DONG JIN (KR)
KIM HYE YUN (KR)
CHO SOO MIN (KR)
Application Number:
PCT/KR2014/003643
Publication Date:
October 30, 2014
Filing Date:
April 25, 2014
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
G01N33/68; G01N33/53
Foreign References:
| KR20110066623A | 2011-06-17 | |||
| KR20040076220A | 2004-08-31 | |||
| US7811769B2 | 2010-10-12 | |||
| KR20120116416A | 2012-10-22 |
Other References:
CHO, SEEN YEONG: "Evaluation of plasma amyloid-beta(amyloid-beta) for diagnosis of Alzheimer's disease", MASTER'S THESIS, February 2009 (2009-02-01), XP008185693
PERRIN RJ; FAGAN AM; HOLTZMAN DM: "Multimodal techniques for diagnosis and prognosis of Alzheimer's disease", NATURE, vol. 461, 2009, pages 916 - 22, XP055074391, DOI: doi:10.1038/nature08538
VAN OIJEN M; HOFMAN A; SOARES HD; KOUDSTAAL PJ; BRETELER MM: "Plasma Abeta(l-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study", LANCET NEUROL, vol. 8, 2006, pages 655 - 660
MAYEUX R; HONIG LS; TANG MX; MANLY J; STERN Y; SCHUPFN; MEHTA PD: "Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk.", NEUROLOGY, vol. 8, 2003, pages 1185 - 1190
SUNDSTROM J; INGELSSON E; RONNEMAA E; ARNLOV J; GUNNARSSON MD; HYMAN BT; BASUN H ET AL.: "Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study", ARCH NEUROL., vol. 8, 2008, pages 256 - 263
HANSSON O; ZETTERBERG H; VANMECHELEN E; VANDERSTICHELE H; ANDREASSON U; LONDOS E; WALLIN A; MINTHON L; BLENNOW K: "Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment", NEUROBIOL AGING., vol. 8, 2010, pages 357 - 367
LOPEZ OL; KULLER LH; MEHTA PD; BECKER JT; GACH HM; SWEET RA; CHANG YF; TRACY R; DEKOSKY ST: "Plasma amyloid levels and the risk of AD in normal subjects in the cardiovascular health study", NEUROLOGY, vol. 8, 2008, pages 1664 - 1671
SLEMMON JR; PAINTER CL; NADANACIVA S; CATANA F; COOK A; MOTTER R; SEUBERT P: "Distribution of Abeta peptide in whole blood.", J CHROMATOGR B ANALYT TECHNOL BIOMED LIFT SCI., vol. 846, no. 1-2, 2007, pages 24 - 31, XP005862570, DOI: doi:10.1016/j.jchromb.2006.08.003
See also references of EP 2990801A4
PERRIN RJ; FAGAN AM; HOLTZMAN DM: "Multimodal techniques for diagnosis and prognosis of Alzheimer's disease", NATURE, vol. 461, 2009, pages 916 - 22, XP055074391, DOI: doi:10.1038/nature08538
VAN OIJEN M; HOFMAN A; SOARES HD; KOUDSTAAL PJ; BRETELER MM: "Plasma Abeta(l-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study", LANCET NEUROL, vol. 8, 2006, pages 655 - 660
MAYEUX R; HONIG LS; TANG MX; MANLY J; STERN Y; SCHUPFN; MEHTA PD: "Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk.", NEUROLOGY, vol. 8, 2003, pages 1185 - 1190
SUNDSTROM J; INGELSSON E; RONNEMAA E; ARNLOV J; GUNNARSSON MD; HYMAN BT; BASUN H ET AL.: "Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study", ARCH NEUROL., vol. 8, 2008, pages 256 - 263
HANSSON O; ZETTERBERG H; VANMECHELEN E; VANDERSTICHELE H; ANDREASSON U; LONDOS E; WALLIN A; MINTHON L; BLENNOW K: "Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment", NEUROBIOL AGING., vol. 8, 2010, pages 357 - 367
LOPEZ OL; KULLER LH; MEHTA PD; BECKER JT; GACH HM; SWEET RA; CHANG YF; TRACY R; DEKOSKY ST: "Plasma amyloid levels and the risk of AD in normal subjects in the cardiovascular health study", NEUROLOGY, vol. 8, 2008, pages 1664 - 1671
SLEMMON JR; PAINTER CL; NADANACIVA S; CATANA F; COOK A; MOTTER R; SEUBERT P: "Distribution of Abeta peptide in whole blood.", J CHROMATOGR B ANALYT TECHNOL BIOMED LIFT SCI., vol. 846, no. 1-2, 2007, pages 24 - 31, XP005862570, DOI: doi:10.1016/j.jchromb.2006.08.003
See also references of EP 2990801A4
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
특허법인 충현 (KR)
특허법인 충현 (KR)
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