Title:
DIAGNOSTIC MARKER FOR HEPATIC CANCER DEVELOPMENT IN CHRONIC HEPATIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/008427
Kind Code:
A1
Abstract:
The method of the present invention for evaluating a subject's risk of hepatic cancer development includes: (1) a step for measuring the GDF15 level of the subject; and (2) a step for relating the GDF15 level to the risk of hepatic cancer development. When the GDF15 level measured in step (1) is higher than a preset cutoff value, then it is indicated that the subject has a high risk of hepatic caner development. When the GDF15 level is lower than the cutoff value, then it is indicated that the subject has a low risk of hepatic cancer development. The present invention further provides a kit for measuring the GDF15 level of a subject to be used in the method of the present invention, and a diagnostic reagent containing anti-GDF15 specific antibody for evaluating a risk of hepatic cancer development in a subject.
Inventors:
HIKITA HAYATO (JP)
MYOJIN YUTA (JP)
TAKEHARA TETSUO (JP)
MYOJIN YUTA (JP)
TAKEHARA TETSUO (JP)
Application Number:
PCT/JP2022/028776
Publication Date:
February 02, 2023
Filing Date:
July 26, 2022
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
G01N33/574; C12Q1/6851; C12Q1/686; G01N33/53; G01N33/543; G01N33/576; G01N33/68
Foreign References:
| CN109781984A | 2019-05-21 | |||
| CN107462720A | 2017-12-12 | |||
| JP2020528138A | 2020-09-17 | |||
| JP2012103211A | 2012-05-31 | |||
| JP2012179047A | 2012-09-20 | |||
| JP2010243406A | 2010-10-28 | |||
| JP2007192557A | 2007-08-02 | |||
| CN111393526A | 2020-07-10 | |||
| JP2021121873A | 2021-08-26 | |||
| JP2022084132A | 2022-06-07 |
Other References:
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FURIHATA CHIE, YOU XINYUE, TOYODA TAKESHI, OGAWA KUMIKO, SUZUKI TAKAYOSHI: "Using FFPE RNA-Seq with 12 marker genes to evaluate genotoxic and non-genotoxic rat hepatocarcinogens", GENES AND ENVIRONMENT, vol. 42, no. 1, 1 December 2020 (2020-12-01), XP093029551, DOI: 10.1186/s41021-020-00152-4
XIONG XIANGYU; YUAN JUPENG; ZHANG NASHA; ZHENG YAN; LIU JIBING; YANG MING: "Silencing of lncRNA PVT1 by miR-214 inhibits the oncogenic GDF15 signaling and suppresses hepatocarcinogenesis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 521, no. 2, 31 October 2019 (2019-10-31), Amsterdam NL , pages 478 - 484, XP085980849, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2019.10.137
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MYOJIN, YUTA: "SST5-3 Hepatic stellate cell autophagy promotes HCC growth via GDF15", ABSTRACTS OF THE 79TH ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION; HIROSHIMA, JAPAN; OCTOBER 1‐3, 2020, vol. 79, 30 September 2020 (2020-09-30) - 3 October 2020 (2020-10-03), pages 1066, XP009543326
CHEN JUANJUAN, TANG DONGLING, XU CHU, NIU ZHILI, LI HUAN, LI YAN, ZHANG PINGAN: "Evaluation of Serum GDF15, AFP, and PIVKA-II as Diagnostic Markers for HBV-Associated Hepatocellular Carcinoma", LABORATORY MEDICINE, AMERICAN SOCIETY OF CLINICAL PATHOLOGISTS, CHICAGO, IL, US, vol. 52, no. 4, 1 July 2021 (2021-07-01), US , pages 381 - 389, XP093029561, ISSN: 0007-5027, DOI: 10.1093/labmed/lmaa089
TERESA A. ZIMMERS ; XIAOLING JIN ; JUAN C. GUTIERREZ ; CARY ACOSTA ; IAIN H. MCKILLOP ; ROBERT H. PIERCE ; LEONIDAS G. KONIARIS: "Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER, BERLIN, DE, vol. 134, no. 7, 22 January 2008 (2008-01-22), Berlin, DE , pages 753 - 759, XP019630698, ISSN: 1432-1335
MYOJIN, YUTA: "Recent advances in research on liver sinusoidal cells. III. Role of sinusoidal parietal cells in tumor microenvironment Influence of hepatic stellate cells in liver cancer microenvironment", KAN TAN SUI JAPAN, ARCMEDIUM, JP, vol. 82, no. 4, 28 April 2021 (2021-04-28), JP , pages 555 - 560, XP009543324, ISSN: 0389-4991
SASAKI HAJIME, HIROSHI KITAJIMA, TAKESHI NIINUMA, HIDEKI WAKASUGI, KAZUYA ISHIGURO, AKIRA YOROZU, GOUTA SUDO, TOMO HATAHIRA, NORIY: "Analysis of the anti-tumor mechanism of BRD4 inhibition in hepatocellular carcinoma", vol. 88, 1 December 2019 (2019-12-01), pages 21 - 35, XP093029565, DOI: 10.15114/smj.88.21
LEE HO-YEOP, NGA HA THI, TIAN JINGWEN, YI HYON-SEUNG: "Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma", CELLS, vol. 10, no. 8, 1 January 2021 (2021-01-01), pages 1901, XP093029568, DOI: 10.3390/cells10081901
MYOJIN YUTA, HAYATO HIKITA, YUKI TAHATA, AKIRA DOI, SEIYA KATO, YOICHI SASAKI, KUMIKO SHIRAI, SADATSUGU SAKANE, RYOKO YAMADA, TAKA: "Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination", ALIMENTARY PHARMACOLOGY & THERAPEUTICS, vol. 55, no. 4, pages 422 - 433, XP093029572, DOI: 10.1111/apt.16691
HIKITA, HAYATO: "Examination of the usefulness of serum GDF15 as a biomarker for liver cancer after hepatitis C SVR", KANO-ACTA HEPATOLOGICA JAPAN, NIHON KANZO KYOKAI, TOKYO,, JP, vol. 62, no. 3, 25 November 2021 (2021-11-25), JP , pages A683, XP009542956, ISSN: 0451-4203
MYOJIN, YUTA: "Serum GDF15 is a biomarker of novel carcinogenicity prediction for chronic hepatitis C liver disease", KANO-ACTA HEPATOLOGICA JAPAN, NIHON KANZO KYOKAI, TOKYO,, JP, vol. 62, no. suppl. 2, 30 September 2021 (2021-09-30), JP , pages A494, XP009542954, ISSN: 0451-4203
GASTROENTEROLOGY, vol. 155, no. 6, December 2018 (2018-12-01), pages 1828 - 1837
SAGNELLI E ET AL., INFECTION, vol. 48, no. 1, February 2020 (2020-02-01), pages 7 - 17
ZHANG CH ET AL., LIVER INT., 2022
HIKITA H ET AL., J HEPATOL., vol. 57, no. 1, July 2012 (2012-07-01), pages 92 - 100
HIKITA H ET AL., CANCER PREV RES (PHILA, vol. 8, no. 8, August 2015 (2015-08-01), pages 693 - 701
JANJUA NZ ET AL., J HEPATOL, vol. 68, 2017, pages 933 - 939
WATANABE T ET AL., J MED VIROL, vol. 92, 2020, pages 3507 - 3515
KANWAL FSINGAL AG, GASTROENTEROLOGY, vol. 157, 2019, pages 54 - 64
LIAW YF ET AL., N ENGL J MED., vol. 351, 2004, pages 1521 - 1531
SIMONETTI J ET AL., HEPATOLOGY, vol. 51, 2010, pages 1531 - 1537
YIM HJLOK AS, HEPATOLOGY, vol. 43, 2006, pages S173 - S181
TOKUSHIGE, K ET AL., HEPATOLOGY RESEARCH, vol. 51, 2021, pages 1013 - 1025
YOSHIJI, H. ET AL., J GASTROENTEROL, vol. 56, 2021, pages 593 - 619
ANGULO P ET AL., GASTROENTEROLOGY, vol. 149, 2015, pages 389 - 97
HAGSTROM H ET AL., J HEPATOL., vol. 67, 2017, pages 1265 - 1273
TATEISHI R ET AL., J GASTROENTEROL., vol. 54, 2019, pages 367 - 376
VAN LOON B ET AL., DNA REPAIR (AMST, vol. 9, 2010, pages 604 - 16
GUICHARD C ET AL., NAT GENET, vol. 44, 2012, pages 694 - 8
HAN ES ET AL., PHYSIOL GENOMICS, vol. 34, 2008, pages 112 - 26
TSAI VWW ET AL., CELL METAB, vol. 28, 2018, pages 353 - 368
KIM J ET AL., NAT METAB, vol. 3, 2021, pages 410 - 427
KANG SG ET AL., ISCIENCE, vol. 24, 2021, pages 102181
MYOJIN Y ET AL., GASTROENTEROLOGY, vol. 160, 2021, pages 1741 - 1754
"NCBI", Database accession no. NM_004864.4
ENGVALL E, METHODS IN ENZYMOL., vol. 70, 1980, pages 419 - 439
WEIS JH ET AL., TRENDS IN GENETICS, vol. 8, 1992, pages 263 - 264
HELD CA ET AL., GENOME RESEARCH, vol. 6, 1996, pages 986 - 994
"Guidelines for the Management of Hepatitis C Virus Infection", July 2020
HEPATOLOGY RESEARCH, vol. 50, 2020, pages 892 - 923
"Clinical Practice Guidelines for Hepatocellular Carcinoma", October 2017
GHANY MG, MORGAN TR.: "Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Viral infection", HEPATOLOGY, vol. 71, 2020, pages 686 - 721, XP071566118, DOI: 10.1002/hep.31060
"EASL recommendations on treatment of hepatitis C: Final update of the series", J HEPATOL, vol. 73, 2020, pages 1170 - 1218
"Guidelines for the Management of Hepatitis B Virus Infection", April 2013
"NAFLD/NASH SINRRYO GUIDELINE 2020 (NAFLD/NASH clinical practice guideline 2020", November 2020, NANKODO CO., LTD.
TOKUSHIGE, K. ET AL., HEPATOLOGYRESEARCH, vol. 51, 2021, pages 1013 - 1025
TOKUSHIGE, K. ET AL., JOURNAL OF GASTROENTEROLOGY, vol. 56, 2021, pages 951 - 963
CANCER, vol. 3, 1950, pages 32 - 35
SAMBROOK, JRUSSELL, DW: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
HEPATOL RES, vol. 50, 2020, pages 791 - 816
J HEPATOL, vol. 56, 2012, pages 908 - 943
HEPATOLOGY, vol. 67, 2018, pages 358 - 380
GASTROENTEROLOGY, vol. 153, 2017, pages 996 - 1005
HEPATOLOGY, vol. 46, 2007, pages 32 - 36
CLIN GASTROENTEROL HEPATOL, vol. 12, 2014, pages 1186 - 1195
DIG LIVER DIS, vol. 51, 2019, pages 681 - 688
MYOJIN, Y. ET AL., ALIMENT PHARMACOL THER., vol. 55, 2022, pages 422 - 433
FURIHATA CHIE: "Attempts at Organ-specific In Vivo Short-term Tests for Environmental Mutagens and Carcinogens in Rodent Liver and Stomach", GENES AND ENVIRONMENT, vol. 35, no. 2, 1 January 2013 (2013-01-01), pages 31 - 45, XP093029549, ISSN: 1880-7046, DOI: 10.3123/jemsge.35.31
FURIHATA CHIE, YOU XINYUE, TOYODA TAKESHI, OGAWA KUMIKO, SUZUKI TAKAYOSHI: "Using FFPE RNA-Seq with 12 marker genes to evaluate genotoxic and non-genotoxic rat hepatocarcinogens", GENES AND ENVIRONMENT, vol. 42, no. 1, 1 December 2020 (2020-12-01), XP093029551, DOI: 10.1186/s41021-020-00152-4
XIONG XIANGYU; YUAN JUPENG; ZHANG NASHA; ZHENG YAN; LIU JIBING; YANG MING: "Silencing of lncRNA PVT1 by miR-214 inhibits the oncogenic GDF15 signaling and suppresses hepatocarcinogenesis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 521, no. 2, 31 October 2019 (2019-10-31), Amsterdam NL , pages 478 - 484, XP085980849, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2019.10.137
XIUYING LIU, XIUMEI CHI, QIAOLING GONG, LEI GAO, YUQIANG NIU, XIAOJING CHI, MIN CHENG, YOUHUI SI, MAORONG WANG, JIN ZHONG, JUNQI N: "Association of Serum Level of Growth Differentiation Factor 15 with Liver Cirrhosis and Hepatocellular Carcinoma", PLOS ONE, vol. 10, no. 5, pages e0127518, XP055615813, DOI: 10.1371/journal.pone.0127518
MOHAB H. HALIM, NOUR A. ABDULLA, ABDELKARIM KAMEL, NABILA ABD EL MAKSOUD, HALLA M. RAGAB: "Significance of growth differentiation factor 15 in chronic HCV patients", JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY, vol. 15, no. 2, 1 December 2017 (2017-12-01), pages 403 - 407, XP055615825, ISSN: 1687-157X, DOI: 10.1016/j.jgeb.2017.08.004
TIAN, XIA: "Study on diagnostic value of serum GDF-15, GP73 and AFP in hepatocellular carcinoma", JIANYAN YIXUE YU LINCHUANG = LABORATORY MEDICINE AND CLINIC, CHONGQING SHI WEISHENG XINXI ZHONGXIN, CN, vol. 18, no. 16, 31 July 2021 (2021-07-31), CN , pages 2438 - 2440, XP009542952, ISSN: 1672-9455
LIU KAIKUN, ZHA BIN-SHAN, LIU YUE-FANG, ZHU JIN, FENG ZHEN-QING, ZHANG JIAN-PING: "Expression of GDF15 in rat early-stage hepatocellular carcinoma and human small hepatocellular carcinoma", ACTA UNIVERSITATIS MEDICINALIS NANJING (NATURAL SCIENCE) [JOURNAL OF NANJING MEDICAL UNIVERSITY (NATURAL SCIENCE)], NANJING UNIVERSITY, CN, vol. 28, no. 4, 1 January 2008 (2008-01-01), CN , pages 439 - 444, XP093029560, ISSN: 1007-4368
MYOJIN, YUTA: "SST5-3 Hepatic stellate cell autophagy promotes HCC growth via GDF15", ABSTRACTS OF THE 79TH ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION; HIROSHIMA, JAPAN; OCTOBER 1‐3, 2020, vol. 79, 30 September 2020 (2020-09-30) - 3 October 2020 (2020-10-03), pages 1066, XP009543326
CHEN JUANJUAN, TANG DONGLING, XU CHU, NIU ZHILI, LI HUAN, LI YAN, ZHANG PINGAN: "Evaluation of Serum GDF15, AFP, and PIVKA-II as Diagnostic Markers for HBV-Associated Hepatocellular Carcinoma", LABORATORY MEDICINE, AMERICAN SOCIETY OF CLINICAL PATHOLOGISTS, CHICAGO, IL, US, vol. 52, no. 4, 1 July 2021 (2021-07-01), US , pages 381 - 389, XP093029561, ISSN: 0007-5027, DOI: 10.1093/labmed/lmaa089
TERESA A. ZIMMERS ; XIAOLING JIN ; JUAN C. GUTIERREZ ; CARY ACOSTA ; IAIN H. MCKILLOP ; ROBERT H. PIERCE ; LEONIDAS G. KONIARIS: "Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER, BERLIN, DE, vol. 134, no. 7, 22 January 2008 (2008-01-22), Berlin, DE , pages 753 - 759, XP019630698, ISSN: 1432-1335
MYOJIN, YUTA: "Recent advances in research on liver sinusoidal cells. III. Role of sinusoidal parietal cells in tumor microenvironment Influence of hepatic stellate cells in liver cancer microenvironment", KAN TAN SUI JAPAN, ARCMEDIUM, JP, vol. 82, no. 4, 28 April 2021 (2021-04-28), JP , pages 555 - 560, XP009543324, ISSN: 0389-4991
SASAKI HAJIME, HIROSHI KITAJIMA, TAKESHI NIINUMA, HIDEKI WAKASUGI, KAZUYA ISHIGURO, AKIRA YOROZU, GOUTA SUDO, TOMO HATAHIRA, NORIY: "Analysis of the anti-tumor mechanism of BRD4 inhibition in hepatocellular carcinoma", vol. 88, 1 December 2019 (2019-12-01), pages 21 - 35, XP093029565, DOI: 10.15114/smj.88.21
LEE HO-YEOP, NGA HA THI, TIAN JINGWEN, YI HYON-SEUNG: "Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma", CELLS, vol. 10, no. 8, 1 January 2021 (2021-01-01), pages 1901, XP093029568, DOI: 10.3390/cells10081901
MYOJIN YUTA, HAYATO HIKITA, YUKI TAHATA, AKIRA DOI, SEIYA KATO, YOICHI SASAKI, KUMIKO SHIRAI, SADATSUGU SAKANE, RYOKO YAMADA, TAKA: "Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination", ALIMENTARY PHARMACOLOGY & THERAPEUTICS, vol. 55, no. 4, pages 422 - 433, XP093029572, DOI: 10.1111/apt.16691
HIKITA, HAYATO: "Examination of the usefulness of serum GDF15 as a biomarker for liver cancer after hepatitis C SVR", KANO-ACTA HEPATOLOGICA JAPAN, NIHON KANZO KYOKAI, TOKYO,, JP, vol. 62, no. 3, 25 November 2021 (2021-11-25), JP , pages A683, XP009542956, ISSN: 0451-4203
MYOJIN, YUTA: "Serum GDF15 is a biomarker of novel carcinogenicity prediction for chronic hepatitis C liver disease", KANO-ACTA HEPATOLOGICA JAPAN, NIHON KANZO KYOKAI, TOKYO,, JP, vol. 62, no. suppl. 2, 30 September 2021 (2021-09-30), JP , pages A494, XP009542954, ISSN: 0451-4203
GASTROENTEROLOGY, vol. 155, no. 6, December 2018 (2018-12-01), pages 1828 - 1837
SAGNELLI E ET AL., INFECTION, vol. 48, no. 1, February 2020 (2020-02-01), pages 7 - 17
ZHANG CH ET AL., LIVER INT., 2022
HIKITA H ET AL., J HEPATOL., vol. 57, no. 1, July 2012 (2012-07-01), pages 92 - 100
HIKITA H ET AL., CANCER PREV RES (PHILA, vol. 8, no. 8, August 2015 (2015-08-01), pages 693 - 701
JANJUA NZ ET AL., J HEPATOL, vol. 68, 2017, pages 933 - 939
WATANABE T ET AL., J MED VIROL, vol. 92, 2020, pages 3507 - 3515
KANWAL FSINGAL AG, GASTROENTEROLOGY, vol. 157, 2019, pages 54 - 64
LIAW YF ET AL., N ENGL J MED., vol. 351, 2004, pages 1521 - 1531
SIMONETTI J ET AL., HEPATOLOGY, vol. 51, 2010, pages 1531 - 1537
YIM HJLOK AS, HEPATOLOGY, vol. 43, 2006, pages S173 - S181
TOKUSHIGE, K ET AL., HEPATOLOGY RESEARCH, vol. 51, 2021, pages 1013 - 1025
YOSHIJI, H. ET AL., J GASTROENTEROL, vol. 56, 2021, pages 593 - 619
ANGULO P ET AL., GASTROENTEROLOGY, vol. 149, 2015, pages 389 - 97
HAGSTROM H ET AL., J HEPATOL., vol. 67, 2017, pages 1265 - 1273
TATEISHI R ET AL., J GASTROENTEROL., vol. 54, 2019, pages 367 - 376
VAN LOON B ET AL., DNA REPAIR (AMST, vol. 9, 2010, pages 604 - 16
GUICHARD C ET AL., NAT GENET, vol. 44, 2012, pages 694 - 8
HAN ES ET AL., PHYSIOL GENOMICS, vol. 34, 2008, pages 112 - 26
TSAI VWW ET AL., CELL METAB, vol. 28, 2018, pages 353 - 368
KIM J ET AL., NAT METAB, vol. 3, 2021, pages 410 - 427
KANG SG ET AL., ISCIENCE, vol. 24, 2021, pages 102181
MYOJIN Y ET AL., GASTROENTEROLOGY, vol. 160, 2021, pages 1741 - 1754
"NCBI", Database accession no. NM_004864.4
ENGVALL E, METHODS IN ENZYMOL., vol. 70, 1980, pages 419 - 439
WEIS JH ET AL., TRENDS IN GENETICS, vol. 8, 1992, pages 263 - 264
HELD CA ET AL., GENOME RESEARCH, vol. 6, 1996, pages 986 - 994
"Guidelines for the Management of Hepatitis C Virus Infection", July 2020
HEPATOLOGY RESEARCH, vol. 50, 2020, pages 892 - 923
"Clinical Practice Guidelines for Hepatocellular Carcinoma", October 2017
GHANY MG, MORGAN TR.: "Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Viral infection", HEPATOLOGY, vol. 71, 2020, pages 686 - 721, XP071566118, DOI: 10.1002/hep.31060
"EASL recommendations on treatment of hepatitis C: Final update of the series", J HEPATOL, vol. 73, 2020, pages 1170 - 1218
"Guidelines for the Management of Hepatitis B Virus Infection", April 2013
"NAFLD/NASH SINRRYO GUIDELINE 2020 (NAFLD/NASH clinical practice guideline 2020", November 2020, NANKODO CO., LTD.
TOKUSHIGE, K. ET AL., HEPATOLOGYRESEARCH, vol. 51, 2021, pages 1013 - 1025
TOKUSHIGE, K. ET AL., JOURNAL OF GASTROENTEROLOGY, vol. 56, 2021, pages 951 - 963
CANCER, vol. 3, 1950, pages 32 - 35
SAMBROOK, JRUSSELL, DW: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
HEPATOL RES, vol. 50, 2020, pages 791 - 816
J HEPATOL, vol. 56, 2012, pages 908 - 943
HEPATOLOGY, vol. 67, 2018, pages 358 - 380
GASTROENTEROLOGY, vol. 153, 2017, pages 996 - 1005
HEPATOLOGY, vol. 46, 2007, pages 32 - 36
CLIN GASTROENTEROL HEPATOL, vol. 12, 2014, pages 1186 - 1195
DIG LIVER DIS, vol. 51, 2019, pages 681 - 688
MYOJIN, Y. ET AL., ALIMENT PHARMACOL THER., vol. 55, 2022, pages 422 - 433
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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