Title:
DIAGNOSTIC PKM2 METHODS AND COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2006055880
Kind Code:
A3
Abstract:
This invention provides a method for diagnosing or prognosing ovarian cancer by detecting the level of expression of pyruvate kinase isoenzyme M2 or fragment thereof in a subject. Applicants report that overexpression of this protein or fragment thereof is correlative with the presence of ovarian cancer in mammals. Applicants also report that overexpression of the protein is not correlative with the presence of an immune response, e.g., the generation of anti-PKM2 antibodies detected by Western blot analysis. Also provided are diagnostic kits and methods to assay for new candidate drugs that treat or ameliorate the symptoms associated with ovarian cancer.
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Inventors:
CONNORS TIM (US)
Application Number:
PCT/US2005/042074
Publication Date:
August 24, 2006
Filing Date:
November 15, 2005
Export Citation:
Assignee:
GENZYME CORP (US)
CONNORS TIM (US)
CONNORS TIM (US)
International Classes:
C12Q1/68; G01N33/53
Domestic Patent References:
| WO2002103035A1 | 2002-12-27 |
Foreign References:
| US6358683B1 | 2002-03-19 | |||
| US5972628A | 1999-10-26 | |||
| US20040152648A1 | 2004-08-05 | |||
| US20020102623A1 | 2002-08-01 |
Other References:
WANG K. ET AL.: "Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray", GENE, vol. 229, 1999, pages 101 - 108, XP004161163
KAURA ET AL.: "Evaluation of the private kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma", J. OBSSTET. GYNAECOL. RES., vol. 30, June 2004 (2004-06-01), pages 193 - 196
OREMEK G.M. ET AL.: "The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma", ANTICANCER RESEARCH, vol. 19, 1999, pages 2599 - 2601, XP000991276
ROIGAS ET AL.: "Tumor M2 pyruvate kinase in plasma of patients with urological tumors", TUMOR BIOLOGY, vol. 22, 2001, pages 282 - 285
OREMEK G.M. ET AL.: "Value of the serum levels of the tumor larker TUM2-PK in pancreatic cancer", ANTICANCER RESEARCH, vol. 17, 1997, pages 3031 - 3033, XP000991284
EIGENBRODT E. ET AL.: "Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas", ANTICANCER RESEARCH, vol. 17, 1997, pages 3153 - 3156, XP000991280
VENTRUCCI M. ET AL.: "Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer", DIGESTIVE DISEASES AND SCIENCES, vol. 49, August 2004 (2004-08-01), pages 1149 - 1155
ZHANG ET AL.: "Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 10, June 2004 (2004-06-01), pages 1643 - 1646
ROIGAS ET AL.: "Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma", UROL. RES., vol. 31, 2003, pages 358 - 362
KAURA ET AL.: "Evaluation of the private kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma", J. OBSSTET. GYNAECOL. RES., vol. 30, June 2004 (2004-06-01), pages 193 - 196
OREMEK G.M. ET AL.: "The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma", ANTICANCER RESEARCH, vol. 19, 1999, pages 2599 - 2601, XP000991276
ROIGAS ET AL.: "Tumor M2 pyruvate kinase in plasma of patients with urological tumors", TUMOR BIOLOGY, vol. 22, 2001, pages 282 - 285
OREMEK G.M. ET AL.: "Value of the serum levels of the tumor larker TUM2-PK in pancreatic cancer", ANTICANCER RESEARCH, vol. 17, 1997, pages 3031 - 3033, XP000991284
EIGENBRODT E. ET AL.: "Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas", ANTICANCER RESEARCH, vol. 17, 1997, pages 3153 - 3156, XP000991280
VENTRUCCI M. ET AL.: "Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer", DIGESTIVE DISEASES AND SCIENCES, vol. 49, August 2004 (2004-08-01), pages 1149 - 1155
ZHANG ET AL.: "Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 10, June 2004 (2004-06-01), pages 1643 - 1646
ROIGAS ET AL.: "Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma", UROL. RES., vol. 31, 2003, pages 358 - 362
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